Cooperative Agreement U01CA301426

Award Date 7/25/25
Completion Date 5/31/30
Dollars Obligated $641K
Federal Grant Program
93.396
Assistance Type
Cooperative Agreement
Place of Performance
Stanford, CA 94305, USA
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The key products and services to be delivered through this 5-year project include: 1) employing molecular barcoding and high-throughput sequencing to quantify the metastatic ability of an extensive panel of over 30 PDAC cell lines across different time points, organ sites, and immune environments; 2) relating the observed metastatic phenotypes to the underlying molecular programs and cell states that confer selection for successful metastasis and immune evasion; and 3) investigating key regulators of metastatic phenotypes using multiplexed functional approaches. The goal is to uncover fundamental determinants of PDAC metastasis through these comprehensive and systems-level approaches.

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