This $1.8 million project grant from the National Institutes of Health's National Institute of Mental Health will fund the development of high-throughput methods for measuring synaptic connectivity at single-cell resolution in the cerebral cortex. Over a three-year period from September 2022 through August 2025, The Broad Institute, Inc. will pursue viral, functional, and molecular approaches to map local cortical circuitry. These include optimizing rabies-based trans-synaptic tracing for...
This $1,609,558 Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports the development of a new microscope for connectomics research. The project, titled "BRAIN CONNECTS: PHOTOEMISSION ELECTRON MICROSCOPY FOR CONNECTOMICS", aims to create a photoemission electron microscopy (PEEM) system that can...
This Cooperative Agreement award for $2,500,000 from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support the Integrative Connectomics Coordination Center (IC3). The IC3 will coordinate the activities of the BRAIN Connects network, which aims to develop technology platforms to generate comprehensive brain-wide connectivity maps in...
This federal Cooperative Agreement award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,860,153 to The Regents of the University of California, San Francisco (UCSF) to establish scalable tools for mapping neural circuit connectivity at the level of defined cell types. The project aims to develop innovative spatial transcriptomic...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
This three-year, $4.45 million project grant from the National Institutes of Health's Trans-NIH Research Support program will fund research into unraveling the developmental relationship between gene expression and long-range cortical projections in neurons. The Allen Institute will receive the funding to improve the resolution and scale of in situ sequencing-based neuroanatomical approaches. This will generate an unprecedented view of how gene expression correlates with and influences the...
The Allen Institute was awarded $883,701 under a Project Grant from the National Institute of Mental Health to develop a robust, low-cost platform for electron microscopy (EM) connectomics. The goal is to establish a widely adoptable system centered on an open source serial sectioning robot implementing a novel collection approach. This will enable EM volumes ranging from 50mm on a side to over 1 cubic millimeter to be routinely sectioned and imaged, making EM connectomics tools available to...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
The Allen Institute will develop scalable technologies for brain-wide connectomics of transcriptomic cell types in the mouse medulla through a $4.7 million project grant from the National Institute of Mental Health. The three-year grant, awarded under the Mental Health Research Grants program, aims to combine high-resolution neuronal morphology with molecular classification to define 2,000 morpho-molecular cell types in the medulla. The Allen Institute will create a platform for faster...
This Cooperative Agreement award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) provides $1,705,580.00 to develop a scalable automated proofreading framework for connectomics. The goal is to build capabilities for cost-effective and time-saving automated methods to replace labor-intensive human proofreading of millimeter-scale connectomic datasets,...