Project Grant R44DE023287

This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded Matregenix Inc. a $976,000 project grant (Award ID R44DE035026) to develop MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. The goal is to establish the efficacy and clinical significance of MATRINOVA, a bilayered membrane produced using...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $305,320 Project Grant to Mobius Biotech LLC to develop a novel 3D printed polycaprolactone (PCL) nasal graft called the Resorb3D Spreader Graft (RSG). This grant aims to evaluate the RSG's tissue integration, inflammatory response, and reconstruction efficacy compared to PDS plates, the currently available resorbable implant, in an...

This federal Project Grant award of $685,594 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to leverage microsurgery and bioprinting techniques to improve vascularization and survival of 3D printed or bioprinted bone grafts for craniomaxillofacial reconstructive surgery. The key products and services to be delivered include: Developing a novel microsurgical "vascular micropuncture"...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $447,009 to Georgia Tech Research Corp to develop a biomaterial-based delivery platform that can facilitate the transfer of exogenous mitochondria to osteoprogenitor cells to promote bone regeneration. The goal is to create a novel approach to improve therapies for craniofacial bone defect regeneration by harnessing the...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,255 to East Carolina University to research and develop dental materials that can inhibit microbial biofilm formation while preserving beneficial oral bacteria. The key objectives are to: 1) synthesize a 2-aminoimidazole (2-AI) derivative and create a new methacrylate-based antimicrobial agent containing...

This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $305,000.00 to Magsorbeo Biomedical Corp to develop a bioabsorbable magnesium alloy for maxillofacial fixation. The project aims to create a magnesium-based implant that can provide temporary mechanical support during recovery and gradually be absorbed by the body, eliminating the need for secondary hardware removal surgeries. Key goals include demonstrating the...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing an off-the-shelf biomaterial that can regenerate craniofacial bone defects of any shape or size. The $300,155 award to Colorado State University aims to evaluate the osteoinductivity of recently identified peptides and screen promising new peptides identified through a peptide microarray approach. The goal...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multifunctional, 3D-printed dental implant capable of preventing peri-implantitis, a common and challenging implant-related oral infection. The $1,963,287 award to Cleveland State University will fund the development of silver-doped amorphous magnesium phosphate bioceramic particles, which will be incorporated...

The federal Project Grant award R03TR004613, funded by the National Center for Advancing Translational Sciences (NCATS - CFDA 93.350), aims to develop novel multiscale bone scaffolds using inorganic polymer materials for bone tissue regenerative engineering. The $141,478 award to North Carolina State University will fund research to optimize the synthesis of biocompatible inorganic polymer-based scaffolds, explore the mechanisms of cell attachment and migration, and investigate the ability of...