This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This federal Project Grant award of $685,594 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to leverage microsurgery and bioprinting techniques to improve vascularization and survival of 3D printed or bioprinted bone grafts for craniomaxillofacial reconstructive surgery. The key products and services to be delivered include: Developing a novel microsurgical "vascular micropuncture"...
This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded Matregenix Inc. a $976,000 project grant (Award ID R44DE035026) to develop MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. The goal is to establish the efficacy and clinical significance of MATRINOVA, a bilayered membrane produced using...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing an off-the-shelf biomaterial that can regenerate craniofacial bone defects of any shape or size. The $300,155 award to Colorado State University aims to evaluate the osteoinductivity of recently identified peptides and screen promising new peptides identified through a peptide microarray approach. The goal...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $250,931 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Children's Mercy Hospital in Kansas City, Missouri. The grant will fund the development and validation of a novel diagnostic modality that integrates dynamic computed tomography (4D-CT) with computational fluid dynamics (CFD) analysis to quantify upper airway obstruction in patients with Robin sequence, a congenital...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multifunctional, 3D-printed dental implant capable of preventing peri-implantitis, a common and challenging implant-related oral infection. The $1,963,287 award to Cleveland State University will fund the development of silver-doped amorphous magnesium phosphate bioceramic particles, which will be incorporated...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $136,711 over 5 years to investigate the role of mesenchymal stem cells and their interaction with neutrophils during rapid maxillary expansion and distraction osteogenesis. The research aims to elucidate the biological mechanisms underlying varied patient responses to maxillary expansion procedures, particularly in...
This federal Project Grant award, valued at $161,762.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of the NG2/CSPG4 protein in the healing of endochondral fractures in the mandible. The research aims to define the specific molecular pathways by which NG2/CSPG4 regulates the differentiation of osteochondral progenitor cells during fracture repair, with the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $441,500 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to the University of Colorado-Denver to develop uniquely high conversion and mechanically robust composite restorative materials for improved dental applications. The award aims to investigate the structure-property relationships and mechanisms that enable these novel polymer composites to achieve exceptional strength, toughness, and wear...