Project Grant R41TR002425

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $317,285 to Rithim Biologics Inc. to develop a novel gene therapy approach to prevent ventricular tachycardia (VT) following a myocardial infarction. The key products and services include: The project aims to finalize development of a gene painting catheter to enable targeted ventricular gene transfer, verify ventricular transgene...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $454,049 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Drexel University. The grant supports the development of an innovative central venous catheter device that can provide continuous and accurate measurements of cardiac output in critically ill patients. Key technical innovations include: 1) Using a Doppler ultrasound...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $437,461 to 3DT Holdings, LLC, a minority-owned biomedical engineering company, to develop a novel stabilization catheter for His pacing lead implant. The goal is to refine the design of a deployable suction flute-tipped lead placement sheath to improve the mapping and placement of His leads, which are used in cardiac resynchronization...

This $606,609 federal Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of minimally invasive, wireless, and multi-site photostimulation devices for cardiac resynchronization therapy. The University of Chicago research team, led by Tian, Hibino, Jia, and Aziz, will design, fabricate, and evaluate a range of...

The National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, has awarded a $331,034 Project Grant to Vector Surgical LLC to develop the Gene Therapy Catheter (GTC) - an electrical pulsing device designed to enhance the delivery of adeno-associated virus (AAV) gene therapy to the liver. The GTC aims to improve the efficiency and safety of liver-directed gene therapies by combining local delivery with electrical pulsing and a double-balloon system to isolate the...

The federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is funding the development of a novel "Metasurface Optical Guidewire" for use in percutaneous coronary intervention (PCI) procedures. The $134,151 award aims to design, develop, and demonstrate these specialized optical guidewires, which leverage metasurface technology to provide precise control of laser-based therapeutic...

This Project Grant from the National Heart, Lung and Blood Institute, part of the Department of Health and Human Services, provides $920,176 under the Cardiovascular Diseases Research program to develop a smart aspiration catheter with fiber optic pressure sensors for mechanical thrombectomy procedures to treat acute ischemic stroke. The catheter will be designed, prototyped and validated at Worcester Polytechnic Institute to provide real-time data to interventionalists on the interaction...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $350,000 Project Grant to Karios Technologies LLC to develop TissueShield, a novel single-use, ready-to-use, sterile, dual-chamber, dual-syringe sprayable hydrogel for preventing post-surgical cardiac adhesions. TissueShield is a 3-component polymer system that can be easily sprayed directly onto the heart, forming a robust anti-adhesion layer within seconds. The...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $323,230.00 to Sirona Medical Technologies, Inc. to develop a multi-channel, dual-energy source generator for their proprietary cardiac ablation catheter system. The goal is to create a customizable generator that can seamlessly switch between radiofrequency (RF) and pulsed field (PF) energy sources and precisely deliver the...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), is funding the development of flexible piezo film intravascular ultrasound (IVUS) arrays on guidewires and catheters. The goal is to integrate IVUS capabilities onto standard guidewires and catheters to enable their routine use during coronary and peripheral artery...