Project Grant R21HL145002

This federal Project Grant award, with an ID of R01HL175602, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant will fund a $1,257,395 study to quantify the long-term effects of electronic nicotine delivery system (ENDS) use on cardiovascular and pulmonary health over a 36-month period. The study will recruit 400 long-term ENDS users and 200 non-users, assessing biomarkers related to cardiovascular and...

The National Institutes of Health (NIH), through the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077), awarded a $669,321 project grant to the Regents of the University of California at Riverside (UC Riverside). The grant supports a 1-year study to characterize new and emerging ingredients, acids, toxicants, and indicators of non-tobacco nicotine in electronic cigarette (e-cigarette) products. The research will involve: Analyzing 600 commercial...

This $1,615,000 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) will fund a multi-year research project conducted by the Regents of the University of California, San Francisco (UCSF) to investigate the cardiovascular health effects of dual use of cigarettes and e-cigarettes. The research aims to: 1) Understand the cardiovascular impacts of dual use of...

This federal Project Grant award of $549,555.45 from the National Institutes of Health (NIH) Office of the Director under the Family Smoking Prevention and Tobacco Control Act Regulatory Research (CFDA 93.077) program supports research to investigate the exposure and respiratory health effects of using new and emerging electronic cigarette (e-cigarette) devices among young adults. The key products and services to be delivered through this 3-year grant, which begins on September 1, 2024, include:...

This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support research to assess the potential immunosuppressive effects of e-cigarette use and its impact on susceptibility to pulmonary infections. The $187,500 award to North Carolina Central University (NCCU), a Historically Black College and University (HBCU), will enable the institution to: 1) model lung cell immune dysfunction...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $1,854,091.28 to Texas A&M University System Health Science Center to investigate the impact of paternal exposure to electronic nicotine delivery systems (ENDS), such as e-cigarettes and e-waterpipes, on thrombogenesis and cardiovascular health in a sex-dependent manner. The research will examine the...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the impact of prenatal exposure to copper from electronic nicotine delivery system (ENDS) aerosols on the immature neonatal pulmonary immune system and IL-10-mediated asthmatic responses. The $900,000 award, spanning from March 2025 to January 2030, will leverage in vitro and in vivo models to determine the role of IL-10 and...

This Project Grant award of $265,239 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to evaluate the chemical composition and toxicity of 6-methyl nicotine and nicotinamide vaping products compared to traditional nicotine e-cigarettes. Specifically, the project will: Analyze the chemical composition and metabolism of 6-methyl nicotine and nicotinamide vaping devices before and after aerosolization using mass spectrometry to...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to understand the mechanisms by which electronic cigarette (e-cigarette) exposure, both direct and in utero, can lead to vascular dysfunction and cognitive impairment. The $619,477 award to the West Virginia University Research Corporation will fund studies to determine the role of the enzyme xanthine oxidoreductase (XOR)...

The National Institute on Drug Abuse (NIDA) awarded a $3,002,492 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Virginia. The grant aims to use hyperpolarized xenon-129 MRI (HXEMRI) as a novel biomarker to quantify pulmonary pathology in young, healthy e-cigarette users. The research has two key objectives: 1) determine the impact of e-cigarette use on pulmonary gas exchange capacity in interstitial tissues and capillaries using HXEMRI, and...