This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), provides $757,157 to the University of California, San Diego (UC San Diego) to develop complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants. The key objectives are to: 1) Develop a method called SCBE-SEQ that combines genome editing with single-cell sequencing to...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $452,375 to The Trustees of Columbia University in the City of New York to develop a platform for rapid and efficient generation of multi-site sequence variants using template-guided gene synthesis. The project aims to advance this synthesis approach by optimizing predictive algorithms, experimental protocols, and robotic automation to produce kilobase-sized DNA constructs up...
The National Institute of General Medical Sciences (NIGMS) awarded a $307,257 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to Sxrna Technologies, Inc. to develop a rapid cloning technology called "SXRNA-SELECT" that aims to decrease the time and increase the protein yields for producing mammalian cell lines for biotherapeutic development. The project will optimize the delivery process for plasmids and SXRNA-bait, demonstrate selection for ratiometric...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $205,926 to Abbratech Inc., a small disadvantaged biotechnology business located in Branford, CT. The overarching goal of this "Fast Track" research project is to develop a comprehensive platform for identifying and validating recombinant antibodies that target protein isoform splice-junction sites. This addresses key...
The Massachusetts General Hospital will receive $3,024,000 through a three-year Project Grant from the National Institutes of Health Trans-NIH Research Support program to develop scalable methods for engineering and characterizing novel CRISPR-associated protein variants. The goal is to address limitations of current CRISPR-Cas enzymes by optimizing machine learning-guided directed evolution to create a catalog of customizable DNA editors with improved properties like expanded target...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $940,288 to Arizona State University (ASU) to develop an innovative platform for targeted protein degradation using DNA nanotechnology. The key objectives are to: 1) optimize a programmable DNA-based protein degradation system, 2) assess the impact of spatial factors on degradation efficiency, 3) integrate the DNA...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
This $653,880 Project Grant awarded by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) supports the development of a high-content, image-based CRISPR screening platform to discover regulators of three-dimensional (3D) genome architecture across multiple length scales. The goal is to advance screening technology to enable large-scale, multi-omic analysis of the spatial organization of the genome, nucleome, and transcriptome. Key...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) aims to develop efficient methods for introducing small genetic changes, known as single nucleotide polymorphisms (SNPs) and variants of uncertain significance (VUS), into the zebrafish genome. The $181,754 award to Iowa State University, effective from September 15, 2024 to August 31, 2026, will leverage the university's "GenEweld" gene editing technology to...