Cooperative Agreement R01FD005092

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $571,107 to support research on the role of complement activation in sepsis-associated acute kidney injury (SA-AKI). The goals of the project are to: 1) strengthen the evidence implicating the complement cascade's role in SA-AKI development; 2) identify a potential therapeutic window to...

This $650,000 Project Grant award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) will fund a 4-year clinical research study titled "PHASE 2A/2B STUDY EMAPALUMAB: A WINDOW OF OPPORTUNITY IN PEDIATRIC APLASTIC ANEMIA". The study aims to evaluate the use of the interferon-gamma neutralizing monoclonal antibody emapalumab as an upfront prophase to stratify newly diagnosed pediatric patients with aplastic anemia for personalized curative therapy. Key objectives...

This Project Grant award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) provides $400,000 to The Children's Hospital of Philadelphia (CHOP) to establish the PKDNET - ARPKD Learning Network. The objective is to accelerate clinical trials for autosomal recessive polycystic kidney disease (ARPKD) by creating a robust data resource to identify a research-ready cohort of children with ARPKD and collect high-quality natural history data. This will help define clinical...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,950 to The Research Foundation For The State University Of New York to develop a microfluidic device that models the complex structure and selective filtration function of the kidney's glomerulus and Bowman's capsule. This "Glomerular-Bowman's Capsule System on a Chip" will...

This $704,672 Phase I SBIR project grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to develop an implantable device to improve vascular access for hemodialysis patients. The project will use state-of-the-art materials and engineering techniques to refine the manufacturability and operational parameters of the device, which features a 3D-printed...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $299,999 Project Grant (CFDA 93.847) to Hibar Microsciences, LLC to develop a prototype for CLEAR, a novel hemodialysis cartridge designed to improve the clearance of protein-bound uremic toxins (PBUTs) from the blood of patients with end-stage renal disease. The key objectives are to: 1) Develop a method for immobilizing lipocalin proteins onto dialysis membrane matrices to enhance PBUT removal; 2) Create and...

This is a Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), in the amount of $548,830.00. The grant was awarded to Nephsmart LLC, a for-profit limited liability company located in Little Rock, AR, to develop and test a device that can predict the future risk of severe acute kidney injury (AKI). The project aims to build a point-of-care test that can...

This $518,661 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to advance the design of hemodialysis cartridges beyond the focus on urea removal. The project will test a novel parallel-plate dialyzer design that controls shear forces to potentially reduce platelet activation and clotting risks for the 548,000 Americans who rely on dialysis. The award to Vanderbilt...

The University of Southern California (USC) was awarded a $465,690 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the potential of urinary extracellular vesicles (UEVs) as a novel and safe therapy for autosomal recessive polycystic kidney disease (ARPKD). The research aims to characterize the nanoparticle properties and therapeutic cargo of UEVs, evaluate...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a multicenter, cluster-randomized, open-label, multiple-crossover trial to compare the use of norepinephrine versus phenylephrine as the first-line vasopressor infusion to prevent postoperative acute kidney injury in adult patients undergoing major non-cardiac surgery under general...