Cooperative Agreement HU00011520031

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $643,614.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate how testosterone modulates Staphylococcus aureus (S. aureus) virulence and infection. The key products and services to be delivered through this 5-year award include: 1) investigating the mechanism by which...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify genomic determinants of antibiotic treatment failure in Staphylococcus aureus bacteremia. The $189,558 award to Duke University aims to use patient data, bacterial isolates, and genomic/laboratory studies to determine the link between bacterial biology and clinical outcomes. The research will focus...

This Project Grant award, valued at $390,000.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research by the University of Colorado-Denver to investigate the molecular mechanisms by which the bacterium Staphylococcus aureus utilizes a specific protease, called SplB, to manipulate the host immune response during infection. The key objectives are to: 1) Identify the host...

This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to characterize the neonatal nasal microbiome following a parent-to-child nasal microbiota transplant. The $401,191 award, effective from June 11, 2025 to May 31, 2027, will support research at The Johns Hopkins University to determine whether bacteria from a parent's anterior nares can be transferred to and engraft...

The federal Project Grant award, ID K22AI177517, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $312,000 award will fund research to develop a single-cell resolution understanding of pathogenesis and antibiotic tolerance in the bacterium Staphylococcus aureus. The research aims to explore the relationship between heterogeneous transcriptional responses to the antibiotic vancomycin and...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $226,253 to The Washington University in St. Louis to conduct research on modulating neutrophil-endothelial interactions by the ADAM10 protein in the context of Staphylococcus aureus infections. The goal is to generate a spatiotemporal analysis of the interaction between neutrophils and the endothelium during the early...

This Project Grant award of $141,609 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate how skin commensal bacteria interact with the immune system to promote tolerance in early life. The primary focus is on understanding how Toll-like receptor 2 (TLR2) sensing of modified ligands on Staphylococcus species supports the induction of commensal-specific regulatory T...

This $709,239 federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to understand the mechanisms underlying Candida auris skin colonization. The funded project, led by researchers at the University of California, San Francisco, aims to: 1) identify C. auris factors that enable hair binding and skin colonization, 2)...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $185,544 to Vanderbilt University Medical Center (VUMC) to conduct research on understanding the role of arginine metabolism in antibiotic treatment failure during Staphylococcus aureus infections. The research aims to elucidate the mechanisms by which arginine metabolism influences antibiotic tolerance in S. aureus,...

The federal Project Grant award of $231,700.00, awarded on January 24, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop biologics capable of blocking Staphylococcus aureus (S. aureus) agglutination and infection. The primary awardee, Texas A&M University System Health Science Center, will characterize the binding properties and neutralization capacity of...