Strategic herpesvirus immune evasion and latency defense (shield)

Active Cooperative Agreement Awarded Last action

Award ID
AY1AX000055
Recipient
Awarding agency
Obligated
$62,208,274

Award facts

Completion date 43% complete
Place of performance
California, USA

Award details come from USAspending.gov.

Transactions

Action Obligated Date
Amendment $0
Amendment $0
Amendment $31,104,137
Original award $31,104,137

Subawards

Subrecipient Amount Awarded
Emory University The project is to develop an integrated sequence-, phylogeny-, structure-, and immunologically driven computational toolkit for antigen engineering that can… $8,695
Trustees Of Dartmouth College $270,872
Weill Medical College Of Cornell University Sallie Permar, MD, PhD of Weill Cornell Medicine will provide scientific guidance and input on aspects of experimental design, data interpretation and analysis,… $588,012
Brigham & Womens Hospital Inc. We propose to support the development of potent, broadly acting anti-herpesviral vaccines, including to gamma-herpesviruses. There exists a great unmet need for… $492,491
University Of California, Davis The project is to develop an integrated sequence-, phylogeny-, structure-, and immunologically driven computational toolkit for antigen engineering that can… $782,067
University Of Texas At Austin $246,568
The Methodist Hospital Research Institute This multi-disciplinary proposal is to ultimately generate efficacious chimeric and multivalent mRNA vaccine designs with broad protection potential against… $390,670
University Of Southern California Task 1: Develop Approach to Quantify Security Vulnerabilities in AI/ML Models Task 2: Develop Approach to Guardrail Models Against Phenotype-of-Concern… $150,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The project is to develop an integrated sequence-, phylogeny-, structure-, and immunologically driven computational toolkit for antigen engineering that can… $295,500
University Of Texas At Austin The overarching goal of America’s SHIELD is to create a cutting-edge platform that integrates artificial intelligence/machine learning (AI/ML)-guided structural… $455,861
The Methodist Hospital Research Institute The overarching goal of America’s SHIELD is to create a cutting-edge platform that integrates artificial intelligence/machine learning (AI/ML)-guided structural… $982,850
Massachusetts Institute Of Technology The Lauffenburger laboratory will undertake multi-variate systems immunology-centric computational modeling for translation of information from nonhuman primate… $149,444
Emory University Durability is a critical consideration in HHV vaccines, where waning immunity later in life may pose a substantial program risk. Drs. Sudhir Pai Kasturi and… $819,522
Brigham & Womens Hospital Inc. We propose to support the development of potent, broadly acting anti-herpesviral vaccines, including to gamma-herpesviruses. There exists a great unmet need for… $492,448
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The ARPA-H APECx project will develop an integrated sequence-, phylogeny-, structure-, and immunologically driven computational toolkit for antigen… $493,485
The Methodist Hospital Research Institute This multi-disciplinary proposal is to ultimately generate efficacious chimeric and multivalent mRNA vaccine designs with broad protection potential against… $397,428
Trustees Of Dartmouth College Project Goals/Overall Objectives The goal of this project is to develop means to rapidly design and evaluate novel vaccine immunogens in the context of… $271,498
The Methodist Hospital Research Institute The overarching goal of America’s SHIELD is to create a cutting-edge platform that integrates artificial intelligence/machine learning (AI/ML)-guided… $968,409
Emory University The Hope Clinic will provide leadership for all aspects of the clinical trial for the phase 1 first in humans testing the different vaccine candidates against… $8,695
University Of California, Davis Human herpesviruses (HHVs) infect most Americans, causing acute disease followed by lifelong, latent infection. Consequences of infection include severe birth… $61,257
University Of Texas At Austin The overarching goal of America’s SHIELD is to create a cutting-edge platform that integrates artificial intelligence/machine learning (AI/ML)-guided… $455,861
University Of Texas At Austin The main activities at UT will be developing novel AI/ML models to improve the key phenotypes of prototype vaccines including stability, binding affinity, and… $241,965
Massachusetts Institute Of Technology The Lauffenburger laboratory will undertake multi-variate systems immunology-centric computational modeling for translation of information from nonhuman primate… $150,000
Weill Medical College Of Cornell University Sallie Permar, MD, PhD of Weill Cornell Medicine will provide scientific guidance and input on aspects of experimental design, data interpretation and analysis,… $599,982
Emory University Durability is a critical consideration in HHV vaccines, where waning immunity later in life may pose a substantial program risk. Drs. Sudhir Pai Kasturi and… $525,006
University Of Southern California Modern vaccine development takes advantage of AI/ML techniques in ever step, from development to deployment. There is a growing concern, however, that modern AI… $150,000
Show all 26

Quick answers

Who received award AY1AX000055?

AY1AX000055 was awarded to La Jolla Institute For Immunology by National Institutes of Health (Department of Health and Human Services) on August 27, 2024.

How much is award AY1AX000055 worth?

$62,208,274 has been obligated on AY1AX000055.

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