Cooperative Agreement 70NANB9H3001

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program, provides $597,683 to the University of Connecticut to develop an injectable, self-powered piezoelectric scaffold for the treatment of osteoarthritis in large animal models. The key products and services to be delivered include: A novel injectable...

Cartilage Inc. received a $256,000 Project Grant award from the National Science Foundation Division of Industrial Innovation on February 15, 2021 to develop a biological adhesive for the fixation and integration of cartilage implants. The award is part of the Engineering program (CFDA 47.041) and will support Cartilage Inc.'s work through January 31, 2022. The Engineering program seeks to improve quality of life and economic strength through fostering innovation in engineering research and...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded Collamedix Inc. a $300,000 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to establish the feasibility of their "CollaLink" collagen-based scaffold for augmenting primary repair of anterior cruciate ligament (ACL) mid-substance tears. The project aims to demonstrate that the CollaLink scaffold, when placed around an ACL tear, can provide a...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,013,625 to the University of Pittsburgh to investigate the use of a porcine small intestine submucosa (SIS) scaffold for temporomandibular joint (TMJ) disc regeneration. The goal is to develop a safe and effective treatment for TMJ disc replacement, addressing the lack of FDA-approved options that leads to joint...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA program "Discovery and Applied Research for Technological Innovations to Improve Human Health", will support the development of a novel biomaterial delivery platform to spatiotemporally deliver bone morphogenetic proteins (BMP2 and BMP9) and promote regeneration of bone and articular cartilage following digit amputation. The $271,664 award, granted on May 10, 2025, will...

This $230,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports a collaborative research project at the Rochester Institute of Technology (RIT) to advance the understanding of articular cartilage, the soft tissue covering the ends of bones in joints. The project will examine how cartilage responds to physical forces relevant to daily activities, integrating theoretical modeling, simulations, and experiments to study how osmotic pressure...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development of an optimized, off-the-shelf alternative to autologous fat grafting for soft tissue repair. The $293,983 award to Insoma Bio, Inc., a biotechnology company in Durham, North Carolina, will evaluate the combination of Insoma Bio's Fractomer tissue repair matrix and the Renuva adipose allograft material from MTF...

This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...

The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...

This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...