Cooperative Agreement 2549904
- This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is providing $275,000 to Dinya DNA Inc. to support the commercial development of a novel DNA synthesis technology. The key products or services being delivered include: Developing new methods to ensure higher fidelity DNA precursors, which are the building blocks for DNA synthesis Reducing synthesis costs by streamlining the DNA synthesis reactions...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program award provides $274,990 to Dencoda LLC to develop a novel DNA-based kinase assay platform. The key products to be delivered are: A highly sensitive, specific, and multiplexed kinase activity assay that can be used as a research tool to discover new therapeutic targets or as a clinical diagnostic test for diseases involving kinase dysregulation, such as cancers, diabetes, and Alzheimer's disease....
- The National Science Foundation awarded Biostorex LLC $303,998 on January 1, 2027, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to explore enzymatic DNA-synthesis technology for scalable and sustainable data storage. The recipient will conduct a proof-of-concept study on light-responsive DNA-building enzymes designed to simplify DNA writing processes by eliminating repeated wash and reset steps that currently limit synthesis speed, increase reagent consumption,...
- Ansa Biotechnologies, Inc. was awarded a $994,682 cooperative agreement from the National Science Foundation under the Engineering program (CFDA 47.041) for the period of April 15, 2021 through March 31, 2023. The award will support Ansa Biotechnologies' efforts to develop reagents for a rapid enzymatic DNA synthesis platform. The Engineering program seeks to improve quality of life and economic strength through fostering innovation in engineering research and development. This award will...
- This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...
- The National Science Foundation awarded Synlibris, Inc. $304,957 on July 1, 2026, under the SBIR Phase I program (NSF Technology, Innovation, and Partnerships, CFDA 47.084) to develop a continuous evolution platform for engineering yeast strains capable of high-titer protein secretion. The project addresses manufacturing bottlenecks in biotherapeutics and industrial enzymes by creating an accelerated natural-evolution technology to discover genetic solutions that enable cells to produce...
- The National Institutes of Health National Human Genome Research Institute awarded $1,077,022 to Bacstitch DNA Inc. on September 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop and optimize a hierarchical in vivo DNA assembly platform for high-throughput construction of long DNA sequences exceeding 80 kilobases. Bacstitch DNA will enhance its E. coli-based assembly platform by transitioning from sequential to hierarchical assembly workflows, integrating orthogonal...
- This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) totaling $1,400,000 aims to advance the manufacturing of ultra-high-density, DNA-enabled nanoelectronics systems. The key goals are to: Develop scalable methods for obtaining high-purity carbon nanotubes, self-aligned single-molecule junctions, and hybrid DNA nanostructures. Establish reliable processes for integrating bottom-up and top-down architectures using field-driven directed assembly and...
- This Project Grant award of $250,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the Massachusetts Institute of Technology (MIT) to develop a novel, sustainable manufacturing framework using DNA for fabricating quantum devices. The key products of this 2-year project (5/1/2025 - 4/30/2027) are the establishment of a DNA-based, energy-efficient manufacturing approach to precisely position quantum materials on silicon chips. This innovative...
- The National Institutes of Health National Human Genome Research Institute awarded $484,634 to Dnali Data Technologies, Inc. on September 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop and commercialize a platform for unbiased amplification of single-stranded DNA oligonucleotides. Current methods for producing and amplifying single-stranded DNA are inefficient, biased, and fail to maintain sequence fidelity or representation, particularly for long templates, very short...
The National Science Foundation awarded Dinya DNA, Inc. a $1.25 million cooperative agreement on August 1, 2026, to commercialize an automated, enzymatic DNA synthesis platform under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The recipient will develop and optimize a hierarchical assembly approach that synthesizes long, complex DNA sequences using small double-stranded DNA precursors assembled enzymatically in exponential fashion, replacing traditional single-nucleotide addition methods that suffer from high error rates and are limited to short strands. Phase II objectives include establishing a robust, automated manufacturing line capable of producing multi-kilobase complex genes with integrated sequence quality control and optimizing process stability and reagent handling protocols for enzymes and reaction components to ensure commercial-grade reliability. The funding aims to reduce costs and production times for DNA synthesis, a fundamental biotechnology tool, while enabling the creation of long and complex sequences. Successful commercialization is intended to strengthen the domestic bioeconomy by providing an onshore, superior source for a critical biotechnological resource, accelerating research development timelines and potentially fostering development of new therapeutics and growth in biomanufacturing. Performance will occur in Oakland, California, with a period of performance from August 1, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/21/26 |