BII: predicting the global host-virus network from molecular foundations

Active Cooperative Agreement Awarded Last action

Award ID
2515340
Recipient
Awarding agency
Obligated
$6,899,962

Award facts

Assistance listing
47.074 Biological Sciences
Completion date 70% complete
Place of performance
New Haven, CT 06511, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The viral emergence research initiative biology integration institute (verena BII) will integrate data and biological theory across the fields of microbiology, immunology, ecology, evolution, and global change biology, working towards a unified understanding that improves our ability to predict viral emergence. The covid-19 pandemic highlights a pressing need to understand the ecology and evolution of emerging viruses. These global dynamics are determined first and foremost by the genetic code of both viruses and their hosts, and by microscopic interactions between the two at the level of proteins and cells. However, biologists frequently struggle to connect theory across these scales. At the heart of this research effort is an open clearinghouse of big data, creating new opportunities to apply artificial intelligence to real-world problems. To foster a core set of data fluency and interdisciplinary research skills, the lighthouse learning community will train participants at every career stage in the boundary-spanning science of the host-virus network, including more than 100 early career scientists. Undergraduates will be introduced to both biology and data science through a course-based undergraduate research experience in ?the fundamentals of disease surveillance,? While graduate students and postdoctoral fellows will explore these methods deeper through a biology integration workshop series, including a new summer in the capitol program in washington, D.C. This cohort of emerging scholars will use open source materials, k-12 outreach, and digital media to harness public interest in emerging diseases like covid-19, raising awareness about key issues while sharing the importance of basic biological research to save lives and protect ecosystems. To identify the mechanistic and molecular rules of life that govern host-virus dynamics at planetary scales, the verena BII will leverage a unique mix of data synthesis, computational innovation, field sampling, and laboratory experiments to identify the molecular underpinnings of host-virus interactions. An unprecedented comparative study of the chiropteran within-host environment will generate and test hypotheses about the immunological adaptations that allow bats to tolerate deadly viruses. In parallel, model-guided experiments will measure the features of the invertebrate immune system that play the greatest role in mosquitoes? Competence as arboviral vectors. Together, these model systems will illuminate the hard-coded basis of host-virus compatibility, supporting new machine learning methods to predict ecological and evolutionary networks and anticipate global risks of viral emergence in a changing climate. More broadly, the verena BII will expand an existing role as a hub of open data, software, and cyberinfrastructure for host-virus interactions, experimental virology, and wildlife disease surveillance. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.- subawards are not planned for this award.

Transactions

Action Obligated Date
Amendment $2,127,644
Amendment $0
Amendment $0
Amendment $0
Original award $4,772,318

Subawards

Subrecipient Amount Awarded
Colorado State University The overall goals of this project are to predict virus-host associations and assign emergence likelihoods to various pairings. CSU is a key contributor to… $711,942
University Of Oklahoma For this National Science Foundation project, entitled “BII-Implementation: Predicting the global host-virus network from molecular foundations”, University… $61,000
Georgetown University "For this funded National Science Foundation project, entitled “BII-Implementation: Predicting the global host-virus network from molecular foundations” (NSF… $125,663
University Of Oklahoma "For this NSF BII grant (led by PI Carlson), University of Oklahoma will lead analysis of bat samples for comparative proteomics and perform various… $814,805
University Of Florida BII-Implementation: Predicting the global host-virus network from molecular foundations UF PI: Sadie J. Ryan will serve as PI and manager for the UF subaward to… $163,370
Washington State University Introduction/Background The Viral Emergence Consortium Design phase resulted in productive collaborations and an excellent track record for data synthesis and… $1,409,473
Cary Institute Of Ecosystem Studies, Inc. Han and staff will co-lead research activities under Theme 2 of this proposal. Specific duties will be to: 1. Coordinate all aspects of project management at… $249,637
The Administrators Of Tulane Educational Fund Within the overall program goal of predicting host-virus networks from molecular foundations, Dr. Frank’s laboratory and Tulane will be responsible for 1)… $247,172

Quick answers

Who received award 2515340?

2515340 was awarded to Yale Univ by Division of Biological Infrastructure (National Science Foundation) on October 1, 2024.

How much is award 2515340 worth?

$6,899,962 has been obligated on 2515340.

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