NSF-BII: integrative movement sciences institute

Active Cooperative Agreement Awarded Last action

Award ID
2319710
Recipient
Awarding agency
Obligated
$6,952,937

Award facts

Assistance listing
47.074 Biological Sciences
Completion date 44% complete
Place of performance
Irvine, CA 92697, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Muscle is the active tissue that drives the remarkable agility of animals, enabling feats of speed, endurance, and maneuverability in challenging environments. Understanding how muscle controls movement is essential for animal performance and evolution, and for maintaining human health throughout life. However, muscle function during fast, unsteady motions in complex environments cannot be accurately predicted by current models. Current understanding is limited by isolation among fields, resulting in knowledge gaps between ?bottom-up? Reductionist approaches that characterize molecules and tissues and ?top down? Organismal approaches that focus on animal behavior. The integrative movement sciences institute (imsi) will bridge these gaps by connecting ?bottom-up? And ?top-down? Approaches to integrate the contributions of mechanical, neural, and sensory systems to movement control. An interdisciplinary team spanning 21 institutions across the country will lead scientific research and training to integrate investigations across structural levels and timescales from molecules to organisms and nanoseconds to generations. The imsi collaborative network will train scientists in interdisciplinary teamwork, mathematical modeling, data analysis, and open data sharing. Imsi activities will drive innovation in biophysics, physiology, biomechanics, neuroscience, and engineering. Understanding the muscular control of agile movement has wide-reaching applications in BIO-technology and the BIO-economy through design of movement therapies, rehabilitation programs and mobility assistance devices. Dynamic muscle function forms a critical foundation for an integrative understanding of movement, yet IT remains a fundamental challenge to predict muscle force output in fast and unsteady conditions. Imsi will integrate muscular control of movement across scales by critically examining assumptions of current approaches, developing new experiments and models to bridge ?bottom-up? And ?top-down? Perspectives, and constructing a dynamic muscle movement paradigm to transform basic science, clinical and technical applications. Cross-cutting themes include unsteady and perturbed movements, multiscale modeling, and unifying invertebrate, vertebrate, and human studies. Research cores include: (1) intrinsic muscle dynamics with rheological and x-RAY diffraction experiments at nanometer to organismal scales; (2) embedded neuromechanical control to investigate how intrinsic mechanics and sensorimotor networks shape unsteady movement; (3) resilience and versatility to determine how variation in musculoskeletal properties and capacity drive whole-body movement; (4) risk-reward and learning, to determine how experience leads to movement optimization when navigating environmental risks and rewards; and (5) diversity and convergence in motor systems to characterize evolution of dynamic muscle function. Imsi faculty have expertise ranging from molecular biophysics of muscle proteins to animal ecology and human-machine interaction. The team-based science, near-peer mentorship and CO-supervisory structure will foster community and provide trainees with a wide mentor network from a range of institutions from primarily undergraduate institutions to research intensive institutions, creating a training pipeline from undergraduates to faculty. Imsi will transform movement sciences by building a new foundation for dynamic muscle function and neuromuscular control of movement that integrates across disciplines, organisms, and structural scales. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.- subawards are planned for this award.

Transactions

Action Obligated Date
Amendment $2,659,320
Amendment $2,468,772
Original award $1,824,845

Subawards

Subrecipient Amount Awarded
Georgia TECH Research Corp Professor Simon Sponberg, Lena Ting, and Greg Sawicki at the Georgia Institute of Technology will contribute to the experimental and modeling activities in… $440,323
Trustees Of The Colorado School Of Mines This BII Implementation project will create a Biology Integration Institute in the interdisciplinary field of Movement Science that was initiated with an NSF… $293,405
Northern Arizona University This BII Implementation project will develop activities toward continuing a Biology Integration Institute in the interdisciplinary field of Movement Science… $318,284
University Of Southern California Drs. Finley, McGowan, and McNitt-Gray will serve in IMSI management and leadership roles for Cores 3 & 4 of the IMSI proposal and will actively engage in… $274,215
University Of Southern California $0
Trustees Of The Colorado School Of Mines This BII Implementation project will create a Biology Integration Institute in the interdisciplinary field of Movement Science that was initiated with an NSF… $0
Northern Arizona University This BII Implementation project will develop activities toward continuing a Biology Integration Institute in the interdisciplinary field of Movement Science… $294,606
Yale Univ The Venkadesan laboratory will contribute to Research Core 1 of the proposed project: Determine how dynamic intrinsic muscle properties contribute to movement… $53,824
University Of Southern California Drs. Finley, McGowan, and McNitt-Gray will serve in IMSI management and leadership roles for Cores 3 & 4 of the IMSI proposal and will actively engage in… $341,775
Georgia TECH Research Corp Professor Simon Sponberg, Lena Ting, and Greg Sawicki at the Georgia Institute of Technology will contribute to the experimental and modeling activities in… $317,042
Trustees Of The Colorado School Of Mines This BII Implementation project will create a Biology Integration Institute in the interdisciplinary field of Movement Science that was initiated with an NSF… $267,960
Yale Univ The Venkadesan laboratory will contribute to Research Core 1 of the proposed project: Determine how dynamic intrinsic muscle properties contribute to movement… $43,303
Trustees Of The Colorado School Of Mines This BII Implementation project will create a Biology Integration Institute in the interdisciplinary field of Movement Science that was initiated with an NSF… $197,229
Georgia TECH Research Corp Professor Simon Sponberg, Lena Ting, and Greg Sawicki at the Georgia Institute of Technology will contribute to the experimental and modeling activities in… $236,071
Show all 14

Quick answers

Who received award 2319710?

2319710 was awarded to University Of California Irvine by Division of Biological Infrastructure (National Science Foundation) on March 1, 2024.

How much is award 2319710 worth?

$6,952,937 has been obligated on 2319710.

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