Block Grant HT94041310018

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will fund research to investigate the physiological impacts of heat waves on elderly individuals with chronic obstructive pulmonary disease (COPD). The $143,784 award, which begins on September 8, 2024, will support activities at the University of Texas Southwestern Medical Center to: 1) Evaluate the cardiovascular, pulmonary, and...

This Project Grant award of $1,473,664 from the National Institute on Aging (NIA), through the Aging Research Federal Grant Program (CFDA 93.866), will support research by Texas Tech University System to investigate the impacts of local heat therapy on skeletal muscle architecture, glycemic control, and frailty risk in older adults with prediabetes. The key aims are to: 1) Determine if local heat therapy improves skeletal muscle characteristics, glucose tolerance, and frailty indicators...

The Department of Agriculture's National Institute of Food and Agriculture awarded a $649,636 project grant under the Agriculture and Food Research Initiative competitive grants program to the University of Florida Division of Sponsored Research. The four-year project aims to study the effects of heat stress on maize pollen development at the molecular level. Researchers will examine how individual stages of pollen formation respond differently to heat stress episodes to identify genetic and...

This Project Grant award in the amount of $445,996 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to determine how mitigating oxidative stress at telomeres can improve the function of T cells in adoptive cell therapy (ACT) models for cancer treatment. The key objectives are to: 1) Mechanistically determine the role of oxidative damage at telomeres on T cell function and how protecting telomeres with an antioxidant protein can improve T cell anti-tumor...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $211,988 to The University of Texas Southwestern Medical Center to research low-energy cooling strategies to mitigate the adverse health effects of heat waves on the elderly. The project aims to evaluate the efficacy of skin wetting and fan use in attenuating core body temperature increases and associated cardiovascular and...

The University of Nebraska received a $650,000 Project Grant under the U.S. Department of Agriculture's (USDA) Agriculture and Food Research Initiative (AFRI) program. The award will fund a 4-year research study to investigate strategies for minimizing the impact of heat stress on the health, growth, and welfare of high-fat finishing livestock. Specifically, the researchers will test the effectiveness of anti-inflammatory dietary compounds in reducing inflammation and associated losses in...

This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $533,225 to the University of Tennessee in Knoxville will fund research to understand how behavioral responses allow some animals to cope with the growing challenges posed by extreme heat and rising temperatures. The research will focus on a cavity-nesting bird species thriving in hot, humid environments in the southeastern U.S. Experiments will: 1) identify causes and consequences of...

The Department of Agriculture's National Institute of Food and Agriculture awarded a $640,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to the University of Florida from June 2022 through August 2026. The grant aims to improve the productivity of Bos indicus-influenced beef cattle in tropical and subtropical grazing environments through heat stress mitigation. Specifically, the University of Florida will evaluate the individual and combined...

This Project Grant award of $448,383 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program aims to investigate the impact of maternal exposure to cyanotoxins, specifically microcystin-LR (MC-LR), on the development and function of the stress axis in offspring. The research, to be conducted at Kent State University from August 2024 to July 2027, will pursue two key objectives: 1) Determining if sub-chronic...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $586,599 to the Sanford Burnham Prebys Medical Discovery Institute to conduct research on the hormetic regulation of autophagy and its role in aging. The project aims to analyze the spatio-temporal requirements for the autophagy-regulating transcription factors HLH-30/TFEB and HSF-1 in mediating heat-induced adaptations, as well as identify the cell-specific transcriptional changes...