Project Grant R21CA296693
Award Date
12/13/24
Completion Date
11/30/26
Dollars Obligated
$446K
Federal Agency
National Cancer Institute
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award, valued at $1,271,780.00, was issued by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to the University of Pittsburgh. The grant supports the development of small molecule adaptor drugs to reprogram a universal chimeric antigen receptor (CAR) T cell therapy for improved targeting and treatment of cancer. Specifically, the research aims to: 1) develop small molecule adaptors for targeting the universal CAR to multiple antigens,...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $626,534 to The Medical University of South Carolina to conduct research on the mechanisms by which transient endoplasmic reticulum (ER) stress can enhance the anti-tumor functions of T cells. The research aims to: 1) Determine how carbon monoxide-induced mitochondrial quality control regulates T cell effector function; 2) Examine how autophagy-induced metabolic changes epigenetically...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $176,712 to the University of Pittsburgh to conduct research on the role of CD91-mediated signaling in cancer immunosurveillance. The project aims to develop a mouse model to investigate how tumor-derived heat shock proteins (HSPs) interact with CD91 on antigen-presenting cells to prime T cell responses against emerging, nascent tumors. Specifically, the research will examine the...
This $103,948 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) aims to investigate mechanisms driving T-cell dysfunction in the tumor microenvironment. The primary objectives are to examine how amino acid availability impacts translation and effector function in tumor-infiltrating T-cells, as well as explore the role of non-coding RNAs in regulating translational suppression during T-cell exhaustion. The research...
This Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research at the University of Pittsburgh to investigate the functional consequences of high glucose culture on adoptive T cell therapies for cancer. The $162,486 award runs from September 2025 through March 2029. The research aims to identify how excess glucose in cell culture media alters T cell signaling pathways and function, potentially impairing the efficacy of adoptive T...
The National Cancer Institute (NCI) awarded a $1,510,463 Project Grant (CFDA 93.396 - Cancer Biology Research) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to conduct research on the regulation of tumor-associated immune macrophages (TAMs) and their metabolic properties. The project aims to elucidate how the composition and activity of the mitochondrial electron transport chain complex IV in TAMs are controlled...
This $552,968 Project Grant was awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to the University of Pittsburgh to conduct research on the role of tRNA modifications in regulating gene expression and cancer stem cell biology in glioblastoma. The research aims to provide molecular insights into how metabolic control of tRNA modifications can reprogram translational programs in glioblastoma stem cells, contributing to tumor heterogeneity and treatment...
This Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) provides $102,324 to the Medical University of South Carolina to conduct research on the role of peroxisomes in enhancing anti-tumor T cell responses. The overarching goal is to elucidate how peroxisome biogenesis impacts adaptive immune function, particularly within the tumor microenvironment, in order to improve the efficacy of adoptive T cell transfer therapies for solid tumors. The...
This $673,526 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) will support research by the University of Pittsburgh to investigate the role of zinc metabolism in therapy-resistant melanoma. The research aims to 1) elucidate how the loss of the p16 tumor suppressor gene affects zinc transporter SLC39A9 expression and zinc homeostasis, and 2) determine how altered zinc levels in the tumor microenvironment impact CD8 T cell function and...
This federal Project Grant award, with ID R35CA283998, was awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Pittsburgh. The $954,000 award will support research aimed at understanding how aging promotes the growth of glioblastoma, an aggressive form of brain cancer, through both cell-autonomous mechanisms and interactions with the tumor microenvironment. The research will leverage spatial transcriptomics and metabolomics of patient tumor...