Purchase Order 75N95022P00601

Cyprotex US LLC was awarded a $28,100 firm fixed price purchase order by the Department of Health and Human Services' National Institutes of Health's National Institute on Drug Abuse to provide absorption, distribution, metabolism, and excretion testing services of drug compounds. The solicitation requested absorption, distribution, metabolism, and excretion testing including solubility, parallel artificial membrane permeability assay, microsomal stability, liquid chromatography-mass...

This is a firm-fixed-price purchase order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the U.S. Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $80,000 contract is for the provision of testing services for 30 compounds, including conducting cytochrome P450 (CYP) inhibition testing, Caco-2 permeability assays, and other absorption, distribution, metabolism,...

This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...

This firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), part of the U.S. Department of Health and Human Services (HHS), to Pharmaron (Exton) Lab Services LLC, doing business as Absorption Systems. The $146,630 contract is for the characterization of the sponsor's test articles via metabolic stability, CYP phenotyping, and in vitro metabolism studies. The contract has no set-aside designation and the work is to be completed by March...

This is a federal contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a leading contract research organization specializing in predictive toxicology and ADME (absorption, distribution, metabolism, and excretion) research. The $18,024.00 firm fixed-price purchase order contract is for the testing of two compounds against key ADME and DMPK (drug metabolism and...

This is a $50,000.00 firm-fixed-price purchase order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for testing of chemical compounds in a human neurite outgrowth assay as part of absorption, distribution, metabolism, and excretion (ADME) and toxicology (ADME-TOX) services. Cyprotex has significant expertise in predictive toxicology, ADME research, and in...

This is a firm-fixed-price purchase order awarded by the National Institute on Drug Abuse (NIDA), a civilian agency under the Department of Health and Human Services, to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $109,392.00 contract is for compound testing services, including plasma protein binding studies, PXR and AhR activation studies, and CYP inhibition assays on various small molecule compounds. This work supports NIDA's mission to seek fundamental...

This is a $24,138.00 firm fixed price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for conducting testing of compounds in cytochrome P450 (CYP) inhibition assays. Cyprotex has previously been awarded prime federal contracts by agencies such as the Environmental Protection...

This firm fixed-price purchase order was awarded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $157,158 contract is for the characterization of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drug candidates using standardized in vitro methods. This work supports...

This is a $78,300.00 firm fixed-price purchase order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency, to Pharmaron, Inc., a minority-owned for-profit organization. The contract is for testing compounds for the blockage of cardiac ion channels, which is a critical step in the drug development process. As a global contract research organization (CRO), Pharmaron has extensive expertise in preclinical research services, including...