This firm fixed-price purchase order was awarded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $157,158 contract is for the characterization of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drug candidates using standardized in vitro methods. This work supports...
This is a federal contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a leading contract research organization specializing in predictive toxicology and ADME (absorption, distribution, metabolism, and excretion) research. The $18,024.00 firm fixed-price purchase order contract is for the testing of two compounds against key ADME and DMPK (drug metabolism and...
This is a firm fixed price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Cyprotex US LLC, a foreign-owned for-profit organization, for $153,215.00 to conduct testing of compounds in absorption, distribution, metabolism, and excretion (ADME) assays over a 1-year period from March 5, 2021 to March 4, 2022. The contract was awarded sole-source without full and open...
This is a firm-fixed-price purchase order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the U.S. Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $80,000 contract is for the provision of testing services for 30 compounds, including conducting cytochrome P450 (CYP) inhibition testing, Caco-2 permeability assays, and other absorption, distribution, metabolism,...
The Department of Health and Human Services National Institutes of Health National Institute of Neurological Disorders and Stroke awarded a $6,338 firm fixed price purchase order to Cyprotex US LLC for ADME-TOX screening services in support of preliminary safety assessment of a new lead candidate for the agency's HER3 receptor project. Work will be performed by Cyprotex US LLC Division in Watertown, Massachusetts over a one year period concluding on August 30, 2024. The award was made using...
This firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian federal agency, to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $87,870.00 contract is for laboratory testing services to evaluate the inhibition of cytochrome P450 (CYP) enzymes. This work supports NCATS' mission of advancing translational science and drug development. Cyprotex has significant experience providing specialized...
This is a firm fixed price purchase order awarded by the National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) to Cyprotex US LLC, a foreign-owned for-profit organization, for $152,060.00 to provide testing of small molecule compounds. The work is being performed in Watertown, Massachusetts and aligns with the agency's testing and assessment of potential drug compounds. The original solicitation was competed among small businesses, but the contract was not set aside....
This is a firm-fixed-price purchase order awarded by the National Institute on Drug Abuse (NIDA), a civilian agency under the Department of Health and Human Services, to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $109,392.00 contract is for compound testing services, including plasma protein binding studies, PXR and AhR activation studies, and CYP inhibition assays on various small molecule compounds. This work supports NIDA's mission to seek fundamental...
This is a $50,000.00 firm-fixed-price purchase order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for testing of chemical compounds in a human neurite outgrowth assay as part of absorption, distribution, metabolism, and excretion (ADME) and toxicology (ADME-TOX) services. Cyprotex has significant expertise in predictive toxicology, ADME research, and in...
This firm-fixed-price federal contract was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $12,295.00 contract is for the provision of specialized testing services to support chemical risk assessment, drug development, and environmental research programs. Cyprotex has a significant Indefinite...
This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic stability testing, CYP phenotyping, hepatocyte stability assays, and permeability assessments. Results will be reported upon completion of each assay over the anticipated one-year period of performance. This follows on from a previous award to Cyprotex to characterize compounds of interest to the NCI's experimental therapeutic pipeline using the same standardized in vitro methods, ensuring scientific comparability of results.