Training Grant NNX15AU64H
- Not listed
- This is a $296,907.57 grant awarded by NASA to The Research Foundation for the State University of New York (Stony Brook University) to study the effects of microgravity and partial microgravity on bone remodeling, as well as evaluate hypergravity as a countermeasure for microgravity-induced bone loss. The objective is to understand the underlying causes of bone loss experienced by astronauts during long-duration spaceflight and develop effective countermeasures to sustain bone health, which...
- This is a $1,999,998.00 grant awarded by the Shared Services Center of the National Aeronautics and Space Administration (NASA) to the Trustees of Indiana University, a public research university, for a project titled "Foundational In Vivo Experiments on Osteocyte Biology in Space". The purpose of the grant is to study the effects of long-term spaceflight on bone health, with a focus on understanding the biological changes in osteocytes (bone cells) and bone matrix properties that...
- This federal contract award was issued by the National Aeronautics and Space Administration (NASA) to Oregon State University (OSU) to study the impact of spaceflight on non-shivering thermogenesis and bone metabolism in mice. The $148,702.00 grant will fund research to test the hypothesis that spaceflight compromises the ability of mice to employ strategies to maintain body heat, leading to increased dependence on non-shivering thermogenesis and associated bone loss. The objective is to measure...
- This is a $300,000.00 federal grant awarded by the National Aeronautics and Space Administration (NASA) to Virginia Commonwealth University (VCU) to examine the effects of simulated microgravity on bone cells and bone health. The grant, which runs from July 2018 to December 2023, has two main goals: 1) to study the response of normal and genetically modified (CRISPR-edited) mouse bone cells to simulated microgravity conditions in vitro using a specialized bioreactor, and 2) to examine the impact...
- This is a Firm Fixed Price Delivery Order contract awarded by the National Aeronautics and Space Administration (NASA) Johnson Space Center to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division. The $443,094.00 contract is for assessing the response of osteoblasts (bone-forming cells) to TetraNite, a material, under microgravity conditions to induce osteoporosis. The contract does not have a set-aside designation. As...
- The National Aeronautics and Space Administration Johnson Space Center awarded a $492,000 firm fixed price delivery order contract to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division. The contract is for a Role of Mesenchymal Stem Cells in Microgravity Induced Bone Loss mission integration and operations support. The contract has a completion date of September 30, 2024 and was awarded on August 25, 2022 without a...
- The National Aeronautics and Space Administration (NASA) Johnson Space Center awarded a $541,866.90 firm fixed price delivery order contract to the University of Colorado Boulder to develop tissue engineered muscle in microgravity as a novel platform to study sarcopenia. The University of Colorado will conduct this research under the NASA contract without a set-aside designation. The period of performance is through December 31, 2021 to analyze the effects of microgravity on muscle atrophy and...
- This is a $150,000.00 grant awarded by the National Aeronautics and Space Administration (NASA) to Louisiana State University (LSU) to conduct a time course study on bone microarchitectural and material property changes in male and female mice during simulated unloading and spaceflight. The grant has a period of performance ending on February 28, 2026. LSU, a major research university, is serving as the prime contractor on this grant. There is no set-aside designation associated with this award....
- This federal contract award, with ID 80NSSC19K0567, was granted by the National Aeronautics and Space Administration (NASA) to Beth Israel Deaconess Medical Center (Bidmc), a prominent academic medical center in Boston, Massachusetts. The contract, valued at $1,959,734.00, is for the "Time Course of Spaceflight Induced Adaptations in Bone Morphology, Bone Strength and Muscle Mass Quality" research project, which was selected in response to NASA's Human Exploration Research...
- This federal contract award, with ID 80NSSC21K0274, was granted by the Shared Services Center (part of the National Aeronautics and Space Administration) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization. The $750,000.00 grant will fund research into how the skeleton's ability to adapt to mechanical loading is crucial for bone health, as exercise promotes hypertrophy but disuse, such as from spaceflight, leads to...
This federal contract award, NNX15AU64H, was issued by the Shared Services Center to Boise State University to conduct research on the effects of microgravity on bone loss and osteoporosis. The $164,997.88 training grant aims to demonstrate how mechanical unloading in microgravity triggers changes in TRPV4 calcium channel transport, leading to increased osteoclast differentiation and bone resorption. The research plan involves experiments using NASA's Rotary Cell Culture System to assess calcium transport in transgenic yeast and HEK cells expressing TRPV4, as well as in osteoclast cultures. This work supports the development of mitigation strategies and clinical practice guidelines for addressing bone loss in astronauts during extended spaceflight. The contract does not have a set-aside designation and is not associated with a larger contract vehicle.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| 6 | Funding Only Action | ($2) | 1/31/19 | |
| Not listed | ($2) | 1/31/19 | ||
| Not listed | $14.5k | 6/7/17 | ||
| 5 | Funding Only Action | $14.5k | 6/7/17 | |
| Not listed | $18.5k | 9/16/16 |