Grant For Research NNX15AL15G
- Not listed
- This is a grant awarded by the National Aeronautics and Space Administration (NASA) to Oregon State University (OSU) to study the impact of microgravity and cold stress on bone loss and immune function in mice. The $358,718 grant is intended to identify the mechanisms by which spaceflight alters the differentiation of stem cells within bone marrow, leading to bone loss, increased fat content, anemia, and impaired immune response. The research will compare the effects of hindlimb unloading...
- This is a $321,332.00 grant awarded by the National Aeronautics and Space Administration (NASA) to Oregon State University (OSU) for research on the effects of spaceflight on bone and fat metabolism. The contract is focused on understanding the mechanisms behind the detrimental changes in bone marrow, fat infiltration, and bone loss observed in astronauts during spaceflight. OSU, a public land-grant research university, has significant expertise in fields like agriculture, engineering, and...
- This is a $1,999,998.00 grant awarded by the Shared Services Center of the National Aeronautics and Space Administration (NASA) to the Trustees of Indiana University, a public research university, for a project titled "Foundational In Vivo Experiments on Osteocyte Biology in Space". The purpose of the grant is to study the effects of long-term spaceflight on bone health, with a focus on understanding the biological changes in osteocytes (bone cells) and bone matrix properties that...
- This federal contract award, NNX15AU64H, was issued by the Shared Services Center to Boise State University to conduct research on the effects of microgravity on bone loss and osteoporosis. The $164,997.88 training grant aims to demonstrate how mechanical unloading in microgravity triggers changes in TRPV4 calcium channel transport, leading to increased osteoclast differentiation and bone resorption. The research plan involves experiments using NASA's Rotary Cell Culture System to assess calcium...
- This federal contract award, valued at $94,694.68, was granted by the National Aeronautics and Space Administration (NASA) to The Ohio State University to conduct ground-based studies on tissue-engineered skeletal muscle models. The objective is to better understand the mechanisms driving muscle atrophy during spaceflight, with the goal of developing countermeasures. This award supports the development of miniaturized, functional muscle constructs that can be used to simulate microgravity...
- This federal contract award, valued at $200,000.00, was issued by the National Aeronautics and Space Administration (NASA) to The Ohio State University under a Cooperative Agreement. The objective is to conduct research on the mechanisms driving skeletal muscle atrophy in astronauts during extended spaceflight. The team, composed of undergraduate students from The Ohio State University and Emory University, will design, build, and test hardware to fly miniaturized tissue-engineered skeletal...
- This is a $296,907.57 grant awarded by NASA to The Research Foundation for the State University of New York (Stony Brook University) to study the effects of microgravity and partial microgravity on bone remodeling, as well as evaluate hypergravity as a countermeasure for microgravity-induced bone loss. The objective is to understand the underlying causes of bone loss experienced by astronauts during long-duration spaceflight and develop effective countermeasures to sustain bone health, which...
- This federal contract award is for a grant to Oregon State University (OSU) from the National Aeronautics and Space Administration (NASA) to conduct research on "Alternative Splicing and Transcriptome Modulation Under Space Flight Response in Plants." The $49,969.00 grant has a period of performance ending on March 31, 2024. The contract does not have a set-aside designation. OSU is a public land-grant university and prominent federal research partner, frequently collaborating with...
- This federal contract award, valued at $99,923.61, was issued by the National Aeronautics and Space Administration (NASA) to Texas A&M University to investigate the impact of a diet high in omega-3 fatty acids on mitigating radiation-induced bone loss. The research aims to determine if this dietary intervention can reduce the generation of inflammatory cytokines in bone tissue, which have been linked to accelerated bone resorption and suppression of bone formation in astronauts exposed to...
- This is a $150,000.00 grant awarded by the National Aeronautics and Space Administration (NASA) to Louisiana State University (LSU) to conduct a time course study on bone microarchitectural and material property changes in male and female mice during simulated unloading and spaceflight. The grant has a period of performance ending on February 28, 2026. LSU, a major research university, is serving as the prime contractor on this grant. There is no set-aside designation associated with this award....
This federal contract award was issued by the National Aeronautics and Space Administration (NASA) to Oregon State University (OSU) to study the impact of spaceflight on non-shivering thermogenesis and bone metabolism in mice. The $148,702.00 grant will fund research to test the hypothesis that spaceflight compromises the ability of mice to employ strategies to maintain body heat, leading to increased dependence on non-shivering thermogenesis and associated bone loss. The objective is to measure changes in gene expression related to fat metabolism, bone formation, and bone marrow adipocytes and osteoclasts in various tissue samples from mice flown on the International Space Station and their ground controls. This research aims to elucidate the mechanisms by which the spaceflight environment impacts energy balance and bone turnover. The award does not have a set-aside designation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/26/17 | ||
| 7 | Other Administrative Action | $0 | 6/26/17 | |
| Not listed | $0 | 3/6/17 | ||
| 6 | Funding Only Action | $0 | 3/6/17 | |
| 5 | Funding Only Action | $44.6k | 2/15/17 |