Delivery Order EPD13013-0001

The Department of Health and Human Services Food and Drug Administration awarded a firm-fixed price purchase order contract worth $249,210.00 to Molecular Devices LLC, a subsidiary of Danaher Corporation, for an ImageXpress Micro 4 High Content Screening System. The system is intended to enable the FDA's National Center for Toxicological Research to perform measurements of intracellular calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes to better understand the mechanisms...

The National Institutes of Health's National Center for Advancing Translational Sciences awarded a $3.86 million firm fixed price purchase order to Molecular Devices LLC for the acquisition of five Molecular Devices ImageXpress Confocal High-Content Imaging Systems, one FLIPR Penta high-throughput cellular screening system, along with associated software, services, consumables, installation, training, customization, maintenance, and technical support. The products and services are to support the...

The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $285,899 firm-fixed price purchase order to Government Scientific Source Inc. to upgrade an existing Opera Phenix Plus high content screening system. The upgrades include a Robot LiveCell system, environmental control unit, liquid handling system, and 40X water objective to enhance capabilities such as environmental control, liquid handling, live imaging, robotic plate handling, image...

This is a federal delivery order contract awarded by the U.S. Environmental Protection Agency (EPA) Office of Research and Development to Novascreen Biosciences Corporation, a for-profit small business. The $594,054.69 firm fixed-price contract is for bioactivity profiling of the ToxCast compound library, which is part of the EPA's ToxCast prioritization program. The contract does not have a set-aside designation. The contract was awarded on October 15, 2015 with a completion date of October 14,...

This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...

This is a $50,000.00 firm-fixed-price purchase order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for testing of chemical compounds in a human neurite outgrowth assay as part of absorption, distribution, metabolism, and excretion (ADME) and toxicology (ADME-TOX) services. Cyprotex has significant expertise in predictive toxicology, ADME research, and in...

The National Institute of Environmental Health Sciences awarded a $5,300 firm-fixed price purchase order to Proteinlinks Inc., a woman-owned minority business, for a pilot and large-scale two-hybrid library screening, screening validation, and sequencing project. The work is described as "TAS:: 75 0884:: TAS POTS # 11-011844 INVOICE # 2H0217 PILOT AND LARGE-SCALE TETR BASED TWO HYBRID LIBRARY SCREENING, SCREENING VALIDATION AND SEQUENCING". The contract has a completion date of...

This firm-fixed-price purchase order was awarded by the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Promega Corporation, a global life sciences company, to provide P450-Glo screening systems including CYP26A1, CYP26B1, and CYP3A4 assay kits. The $123,592.50 contract supports the Tox21 collaboration between NCATS, the National Toxicology Program, EPA, and FDA, which aims to screen thousands of compounds in vitro to develop better toxicity...

The U.S. Environmental Protection Agency awarded a $438,903.36 firm fixed price delivery order to Biospyder Technologies, Inc. for high-throughput transcriptomics targeted RNA sequencing analysis of cell lysates as part of the Tox21 Consortium Cross Partner Consortium Project 5. Biospyder will perform the work in Carlsbad, California under EPA contract number 68HERC20D0028, task order number 68HERC21F0055. The sequencing analysis supports the Tox21 program's effort to develop alternative methods...

This firm fixed-price purchase order was awarded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $157,158 contract is for the characterization of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drug candidates using standardized in vitro methods. This work supports...