Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)
Closed Posted
- Opportunity number
- RFA-DC-25-003
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $500,000
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- For Profit Organizations
- Independent School Districts
- County Governments
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- Small Businesses
- Other
- Non-501(c)(3) Nonprofits
- City/Township Governments
- State Governments
- Higher Education Inst. (Public)
- Higher Education Inst. (Private)
- Special District Governments
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Deafness and Other Communication Disorders is soliciting applications for a cooperative agreement to fund high-risk clinical trials developing in vivo high-resolution imaging technologies for the human inner ear, with applications due October 1, 2026.
The opportunity is open to for-profit organizations, nonprofits (501(c)(3) and non-501(c)(3)), higher education institutions (public and private), government entities (state, city, county, tribal, and other), small businesses, special district governments, independent school districts, and eligible institutions including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander serving institutions, and tribally controlled colleges and universities. Non-domestic entities are also eligible.
Projects must focus on improving resolution of existing imaging techniques or developing novel approaches to visualize inner ear structures—including hair cells, otoliths, membranes, ions, and vasculature—with significantly greater detail than currently possible. Structural and functional imaging, including visualization of dynamic elements, is emphasized. Proposals may include development of new imaging probes or contrast agents. Studies in humans are required; intermediate studies in animal models or anesthetized humans must articulate a clear methodological path to awake human application or define limitations and clinical utility. Multidisciplinary team approaches are strongly encouraged.
The mechanism is a U01 cooperative agreement, designating substantial federal involvement and collaboration. Funding is provided under Assistance Listing 93.173 (Research Related to Deafness and Communication Disorders). The full RFA and application instructions are available; applicants must follow both general and research-specific instructions in the provided form guidance package.
Synopsis
This funding opportunity aims to support high risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. Structural and functional aspects, including visualizing dynamic elements, are important to developing new and improved techniques. Projects may also focus on developing new imaging probes or contrast agents that can enhance visualization of the inner ear structures. Research supported in response to this RFA is expected to significantly advance the ability to visualize auditory and vestibular components, such as hair cells, otoliths, membranes, ions, and vasculature, in detail in awake patients in a clinical setting using non-invasive techniques. To achieve this goal, a multidisciplinary team approach that takes advantage of the expertise of each team member is highly encouraged. Studies in humans must be proposed to develop,advance, or test the needed technology. Any intermediate studies must articulate a clear path of the proposed methodology to application in awake humans or define the limitations and the usefulness in anesthetized humans.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| RFA-DC-25-003-Full-Announcement.html | HTML file | |
| PKG00289896.pdf |
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