US Pediatric Proton and Photon Therapy Cohort
Closed Solicitation Posted
- Solicitation number
- 75N91022Q00065
- Agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541990 All Other Professional, Scientific, and Technical Services
- Place of performance
- United States
Notice details come from SAM.gov. Updated .
About this opportunity
The National Cancer Institute seeks to establish the US Pediatric Proton and Photon Therapy Cohort, a retrospective cohort study comparing risks and benefits of proton therapy versus photon therapy for pediatric cancer patients. Contractors shall retrieve de-identified clinical and treatment data from existing medical records of eligible pediatric patients treated with proton or photon therapy at their institution. Data will be used to evaluate second cancer risks and other adverse effects. The response period for questions has been extended to October 18, 2022, and proposals are due by the same date.
There is no set-aside designation. The place of performance is within the United States. Contractors will provide data for an unspecified number of proton-treated and photon-treated pediatric cancer patients dating back to eligible patients' original treatment dates to allow for prospective follow-up in the study. This will help quantify long-term health outcomes and risks for children undergoing these radiation therapy methods for cancer.
Notice text
***Amendment 1 - Due date for Receipt of Quotations has been extended. Response period for Questions has been extended. See Amendment 1 to the solicitation attached.
The Radiation Epidemiology Branch (REB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI) carries out studies to quantify second cancer risks associated with ionizing radiation exposures in pediatric cancer patients. REB has a specific interest in the risk of second tumors following proton therapy in children, because concerns have been raised about whole-body scatter doses from neutrons, brain necrosis and other late effects including second tumors.
Pediatric radiation oncology is undergoing rapid changes due to the widespread introduction of proton therapy. By reducing high-dose exposure to nearby normal tissue, protons should reduce a wide-range of serious adverse-effects, such as second cancers. To date, few studies have directly evaluated the potential benefits or risks of protons for children, and some case series have raised concerns about serious unanticipated side-effects, such as brain necrosis. There is widespread agreement amongst the clinical and scientific community that large-scale collaborative efforts are urgently required to address these questions. Therefore, the NCI established the US Pediatric Proton and Photon Therapy Cohort, a retrospective cohort study with prospective follow-up including pediatric cancer patients treated with proton therapy and a comparison group of similar patients treated with photon therapy. This new cohort will build upon a foundation created by the US Pediatric Proton Consortium Registry (PPCR), which currently includes 20 US proton therapy centers and has recruited >3,000 pediatric proton patients who have actively enrolled in the registry since 2012.
The goal of this acquisition is to obtain data on a group of proton-treated pediatric cancer patients and a group of photon-treated pediatric cancer patients to serve as a comparison group. The contractor shall retrieve data from existing medical records for pediatric cancer patients treated at their institution with proton or photon therapy. De-identified clinical and treatment data obtained from this procurement will be used to evaluate the risks and benefits of proton therapy versus photon therapy for children with cancer.
See Solicitation attached for complete details.
Files
| File | Type | Posted |
|---|---|---|
| SF30 Amendment 1_signed.pdf | ||
| RFQ 75N91022Q00065_8.29.2022.pdf |
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