Synthesis of pharmaceutically active small molecules

INTRODUCTION
PURSUANT TO FAR Subpart 5.2-Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT ACTION.

THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Center for Advancing Translational Sciences (NCATS) intends to negotiate and award a contract/purchase order for "Expansion of NCATS Pharmaceutical Collection (NPC)" with Pharmaron, Inc.,
201 East Jefferson Street, Louisville, KY 40202.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE
The intended procurement is classified under NAICS code 325998 - All other Miscellaneous Chemical Product and Preparation Manufacturing, with a Size Standard of 1,000 Employees.

REGULATORY AUTHORITY
The resultant contract/purchase order will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular (FAC) 05-95, January 19, 2017.

STATUTORY AUTHORITY
This acquisition is conducted as non-competitive under the authority of 41 U.S.C. 253(c)(1) under provisions of the statutory authority of FAR Subpart 6.302-1 - Only one response source and no other supplies or services will satisfy agency requirements.

DESCRIPTION OF REQUIREMENT
Project Description, Background and Purpose

The NCATS Pharmaceutical Collection (NPC) is a comprehensive, publicly-accessible collection of approved and investigational drugs for high-throughput screening that provides a valuable resource for both validating new models of disease and better understanding the molecular basis of disease pathology and intervention.

The purpose of this contract is to procure the custom syntheses of up to 340 pharmaceutically active small molecule compounds (25-100 mgs. each) to expand the NCATS Pharmaceutical Collection for use in mission critical chemical library screening campaigns.

Required Deliverables:
1. Analytical data with purity, LC/MS (>95% area)
2. LC/MS data conforms to structure of the compound
3. NMR data conforms to structure of the compound
4. Complete report of synthetic procedures to create the compound with all associated:
i. Analytical data
ii. Reaction schemes
iii. Reagents list used during the creation
iv. Work up procedures
v. Final yield (in mg) and purity values

Delivery Schedule
Periodically, over the course of the 1 year Period of Performance.

CLOSING STATEMENT
This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice.

Responses to this notice must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses must be received by September 20, 2017 by 5:00pm EST and must reference number HHS-NIH-NIDA-SSSA-SS-17-601.

Responses must be submitted electronically to Bruce Anderson at bruce.anderson@nih.gov and must reference the solicitation number HHS-NIH-NIDA-SSSA-SS-17-601, on your electronic request. FAX requests are not accepted.

"All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."