Synthesis of Chemical Substances

See attached for additional information

Background

The Drug Enforcement Administration’s (DEA) Diversion Control Division (DC), Drug and Chemical Evaluation Section is responsible for the evaluation of drugs and chemicals to determine if these substances are being abused. These evaluations are then used by DEA to develop appropriate drug controls and determine the status of controlled, excluded, or exempted drugs and drug products. In order for DEA to determine the abuse potential of drugs and chemicals, scientific and medical data for these drugs are needed to initiate the administrative procedure to place these substances under regulatory control of the Controlled Substances Act (CSA).

There are numerous novel psychoactive substances (NPS) being abused in the United States. These substances span a wide range of pharmacological classes (i.e. hallucinogens, stimulants, depressants, etc.) and pose a significant risk to the public safety. Additionally, there is an expansive range of chemical structures that make-up the substances in each pharmacological class. The volume of substances being marketed illicitly is rapidly increasing due to small changes to the chemical structures of known substances of abuse. To best protect the public from the dangers of these new drugs, the DEA needs to be able to expeditiously obtain and study these emerging substances. As such, the synthesis of requested substances will be used in the initial collection of information, or to further enhance what is already known about those substances. The information gathered from the procurement, and further study of these substances, will support the goals of the Diversion Control Program.

This BPA is intended for use for all DOJ components, but it is anticipated DEA will be the primary component issuing call orders.

Brief Description of Work

Contractor shall custom synthesize a large variety of chemical substances. Substances span a wide selection of chemical classes, such as cannabinoids, cathinones, opioids, etc. Synthesis and purification should yield varying quantities ranging from milligram- to gram-scale production. The contractor shall be familiar with current methodologies to minimize the lead time for synthesis and delivery of the requested substances. Synthesis shall be completed in the shortest amount of time practical.

Additional Information

All communications concerning the solicitation, including any of a technical nature, shall be made through the Contract Specialist. All questions, technical or otherwise, shall be in writing and sent to FACD.Proposal.Submission@usdoj.gov and Jennifer.b.jordan@usdoj.gov no later than July 20, 2021 at 1:00PM EST. All questions and answers will be provided to contractors as an amendment to the solicitation prior to the quote due date.

The Government may reject all offers received in response to this solicitation, if doing so is in the best interest of the Government. Late submissions will not be accepted. No telephone or fax requests will be accepted. This solicitation does not commit the Government to pay any costs incurred in the submission of a quotation. Quotes shall be submitted electronically to Jennifer Jordan by Aug 3, 2021 at 1:00PM EST via email at FACD.Proposal.Submission@usdoj.gov and Jennifer.b.jordan@usdoj.gov and please reference 15DDHQ21Q00000083 in the subject line of the email quote submission.