Microelectronic Monitoring of Cellular Status
Award Notice Posted
- Solicitation number
- 18-233-SOL-00115
- Agency
-
Program Support Center
Department of Health and Human Services
- Awarded
- to Acea Biosciences, Inc.
- Set-aside
- Total Small Business
Opportunity facts
- Contract number
- 75P00118D00011 Federal IDV award
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- PSC
- Not on record
Notice details come from SAM.gov. Updated .
Notice text
The Environmental Protection Agency requires a contractor to perform microelectronic monitoring of cells in culture to measure altered cellular physiology/pathology in response to exposure to potential environmental toxicants. Use of this approach provides a sensitive measure of changes in cellular physiology that may correlate with toxic activities of test compounds. These results will be used in the ToxCast Project for prioritizing compounds for more in-depth toxicological evaluation. Use of physiologically relevant cells (lines) is required, including cells with phase I and phase II metabolic capabilities as well as primary cells. Co-cultures of multiple cell types that provide relevant physiological conditions are also of interest. The Contractor shall use a microelectronic cell monitoring system to measure the response of one or more rodent or human cells types to compounds from the ToxCast library. The compounds from the ToxCast library will be supplied to the contractor by the EPA or by an EPA contractor.
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