NHP_PWS_28_Sept_2016.pdf

PERFORMANCE WORK STATEMENT

TITLE: WRAIR Non-human Primate (NHP) Colony Maintenance Contract

SCOPE OF WORK:

The Contractor shall provide for the year-round husbandry and health maintenance of a primate colony to hold and breed Specific Pathogen Free Indian Origin (SPF IO) rhesus macaques, non-human primates (NHP), owned by Walter Reed Army Institute of Research (WRAIR), and managed by WRAIR Veterinary Services Program, (VSP).

When required by the Government, the monkeys shall be quarantined, immunized, and transported as directed.

The base size of the colony is expected to be approximately 320 NHPs at the initiation of this contract. The colony size may expand or contract based on the needs of the Government. The Contractor shall be able to accommodate a surge of up to 200 additional NHPs.

Based on current and projected research needs, the Contractor will be expected to provide a minimum of 50 research naïve (RN) 2.5-3 year old, >3.5 Kg SPF IO rhesus macaques per year. Breeding shall be conducted in multi-animal housing arrangements.

All NHPs housed under this contract will be provided by the Government and will remain the property of the government unless sold. At the conclusion of the contract performance, the Government will direct the disposition of the NHPs. Any approved costs incurred with regard to animal transportation and/or relocation (to include completion of diagnostics required for transport) following conclusion of the contract will be reimbursable by the Government.

Work is to be performed at the Contractor’s facility. The Contractor bears the responsibility of scheduling personnel to satisfy the requirements set forth in the statement of work.

The Contractor will maintain a digital system of records to store, analyze and display data on all past and present NHPs of the colony for the duration of the contract. The Contractor shall establish and maintain a copy of animal records on the designated WRAIR Animal Management System (AMS), a digital record keeping system.

The Contractor shall provide services to purchase additional NHPs and services to sell Government-owned NHPs.

The Government anticipates the availability of $1 million per year for the combined efforts of purchasing new NHPs and the services required to sell Government-owned NHPs. The contractor may propose a separate administrative fee for their services to sell Government-owned NHPs. Separate task orders shall be awarded for the purchase of new NHPs and the sale of Government-owned NHPs. Any proceeds on the sale of Government-owned NHPs above costs to sell, transport NHPs, and contractor administrative fee, shall be credited back to the Government on the animal husbandry and maintenance contract.

1.0 BACKGROUND:

WRAIR is a leader in infectious disease research. A critical component to this research is the use of SPF IO RN rhesus macaques. It is difficult to obtain these NHPs in sufficient number and of sufficient age to meet WRAIR research objectives on the open market in a timely manner. Due to this, WRAIR maintains a breeding and holding colony of approximately 320 SPF IO rhesus NHPs to meet the demand. The WRAIR Veterinary Services Program (VSP) maintains oversight of this colony, but the daily operation of a primate colony of this size exceeds the capabilities of the WRAIR vivarium and its staff. The WRAIR requires a separate entity to house and maintain this colony year round to include 24-7 security, routine husbandry, routine and emergency veterinary care and breeding management to these NHPs.

The Contractor shall furnish supplies, services and facilities necessary for animal husbandry and shall be responsible for the care and feeding of the NHPs and general maintenance and sanitation of the facilities in such a manner as to maintain the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) accreditation. The Contractor shall be accredited and maintain AAALAC accreditation throughout the performance of this contract.

1.1 Objectives:

The contractor shall provide, manage and operate a holding/housing and breeding colony of SPF Indian origin Macaca macaques (rhesus) NHPs for duration of the contract. Purchasing and selling services shall be identified as an optional task as the Government requires. The base size of the colony is expected to be approximately 320 NHPs at the initiation of this contract.

1.2 Non-Personal Services

This award identifies services that are strictly non-personal in nature.

1.2.1 Severable / Non-Severable Services

This award identifies services that are severable in nature

1.2.2 Inherently Governmental Functions

This requirement has been reviewed and contains no services that are inherently governmental functions.

2.0 TASKS:

2.1 Task Management

The Contractor shall provide all NHP animal husbandry/maintenance services in accordance with DoD, federal, state, and local regulations and industry standards, to include Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), USDA, Public Health Service policy, Animal Welfare Act and standards described in The Guide for the Care and Use of Laboratory Animals, 8th edition. Additionally, the Contractor shall designate a single manager to oversee this task and supervise staff assigned to this task.

2.1.1 Monthly Financial Progress Report (MPR)

The Contractor shall ensure that a MPR is submitted outlining the financial expenditures, billings, progress, status, and any problems/risks or issues encountered in the performance of this task. The MPR shall provide sufficient detail to enable the Contracting Officer’s Representative (COR) to monitor task performance and identify variations in actual versus planned performance as well as monitor cost expenditures to ensure services are in compliance with allotted funds.

The Contractor shall ensure that any Contractor projected travel and Other Direct Costs (ODCs) are within the spending plan; coordinating for COR approval prior to travel or ODCs expenditures.

The Contractor shall also require all subcontractors to provide input to the MPR where there are critical or significant tasks related to the prime contract. Critical or significant tasks shall be defined by mutual agreement between the Government and Contractor.

2.2 Transition and Shipping Services

Transition includes those services and the action that transfers responsibility of the animal colony and all associated administrative actions to include shipment of NHPs, diagnostics in preparation for transition, quarantine efforts and transfer of records. The incumbent Contractor shall coordinate shipment and transition with the gaining Contractor.

Shipment will comply with all current federal, state and local requirements for the shipment of nonhuman primates.

Shipping includes those services and the action to ship a specified number of NHPs in support of research protocols or a movement of NHPs upon direction of the COR. Services shall include, but are not limited to, shipment of NHPs, diagnostics in preparation for transition, quarantine efforts and transfer of records.

2.2.1 Animal Delivery

The Contractor shall establish procedures to ensure a smooth transition of all management and functional responsibilities identified in this PWS as coordinated with and approved by the COR. The Contractor shall ensure all responsibilities are transferred without any degradation in service. Cages shall be in accordance with the United States Department of Agriculture (USDA) and International Air Transport Association (IATA) guidelines (if applicable). Each compartmentalized cage shall have separate water and feed containers for each compartment.

Each shipment of NHPs shall be held separately while under quarantine following local Standard Operation Procedure (SOP). If possible, a representative for the Government will be available on site to inspect NHPs during receipt at final destination.

2. 2.1.1 The Contractor shall insure the transporter maintains and provides proof of liability insurance with coverage for the entire colony value in the event of damage or injury resulting from an accident/mishap during transport. Proof of this insurance shall be provided as part of the transition plan.

2. 2.1.2 The Contractor shall in accordance with the COR, determine if any NHPs will be culled from shipment (based on cull report provided by Contractor), the time of acceptance, site of delivery and mechanisms of shipment.

2.2.1.3 Upon written request, the Contractor shall provide biological samples for pre-screening of NHPs prior to shipment. Each shipment of NHPs shall be held separately while under quarantine for a minimum of 10 days before transportation. During quarantine, NHPs shall be tuberculin tested twice, and receive an initial dose of antihelmintic. All NHPs will have serum drawn to be tested for Herpes B virus and retroviruses. (Simian Retrovirus (SRV), Simian T-Cell Lymphotropic Virus (STLV), Simian Immunodeficiency Virus (SIV)). Only seronegative NHPs will be shipped to the Government, unless the COR otherwise approves.

2.2.1.4 NHPs identified for shipment to the Government includes the following:

・ Seronegative for MHV1, SRV, STLV & SIV. (previously stated in PWS 2.2.1.3).

・ Generally free of endoparasites and ectoparasites (previously stated in PWS 2.6.1).

Vaccinated for measles if requested (Previously stated in PWS 2.6.1).

Within the weight and age limits specified in the protocol they will be assigned to and in general good body condition.

Fecal cultures will be completed in accordance with Contractor SOP. NHPs that are culture positive will be identified and may be treated per Contractor SOP in consultation with Government veterinarians.

Free of obvious infectious diseases, genetic defects, musculoskeletal abnormalities and extreme psychological issues (SIB).

2.2.1.5 All animal health records, breeding records, and colony history, to include digital and any paper records, will be transferred to the gaining Contractor prior to animal shipment. Government shall determine the time and site of delivery but the Contractor will provide expertise for the mechanisms of shipment. Contractor shall coordinate shipment upon approval and receipt of Government instruction

2.2.2 Transition Services

2.2.2.1 RESERVED

2.2.2.2 Transition Out Plan – Optional Task

Contractor will provide a detailed, 90-day transition out plan outlining all aspects of successful transition to include animal quarantine, diagnostic testing, animal transportation and delivery, and necessary administrative tasks.

A Cull Report identifying NHPs that may not be suitable for transport due to illness, age, etc., must be provided to the Contracting Officer Representative(COR) prior to final transport. The Transition Out Plan shall include, but is not limited to:

Coordination of plans with Government representatives.

Review evaluation and transition of current support services.

Transition of historic data and records to new Contractor system.

Transfer of NHPs, required diagnostics and recording of such, and quarantine as required.

Provide proof of insurance for transporter.

Transfer of all animal records to include digital and paper records.

Transfer of Government Furnished Equipment (GFE), Government Furnished Information (GFI), and GFE inventory management assistance.

2.3 Contingency Operations Plan and Emergency Operations

2.3.1. Contingency Operations

The Contractor shall develop a Contingency Operations Plan. A draft Contingency Operations Plan shall be submitted with contract proposal. The plan shall document Contractor procedures to maintain WRAIR support during an emergency. This plan shall specifically address the risks inherent to the particular facility while also demonstrating the flexibility to address less likely scenarios. This plan should consider natural, national, and localized disaster related events requiring preplanning and execution; events concerning entities with intent to damage or disrupt colony operations; and at a minimum, description of how the Contractor will account for their employees during an emergency; and planned temporary work locations or alternate facilities as applicable.

. The Contingency Operations Plan shall include the following:

• A description of the Contractor’s emergency management procedures and policy.

o A description of how the Contractor will account for their employees during an emergency.

• Planned temporary work locations or alternate facilities.

• How the Contractor will communicate with WRAIR during emergencies o A list of primary and alternate Contractor points of contact, each with primary and alternate:

Telephone numbers, E-mail addresses

• Procedures for protecting Government furnished equipment (if any).

o Procedures for safeguarding sensitive and/or classified Government information (if applicable).

2.3.2 Operations During Emergency Situations

Individual contingency operation plans shall be activated immediately after determining that an emergency has occurred, shall be operational within twelve (12) hours of activation, and shall be sustainable until the emergency situation is resolved and normal conditions are restored or the contract is terminated, whichever comes first. When any disruption of normal, daily operations occur, the Contractor Task Manager shall promptly open an effective means of communication with the COR and verify:

• Key points of contact (Government and Contractor) o Temporary work locations (alternate office spaces, telework, virtual offices, etc.), if applicable, o Means of communication available under the circumstances (e.g. email, webmail, telephone, FAX, courier, etc.)

• Essential contract performance expected to continue production by priority.

The Contractor Task Manager, in coordination with the COR, shall make use of the resources and tools available to continue WRAIR contracted functions to the maximum extent possible under emergency circumstances. The Contractor shall obtain approval from the COR and Contracting Officer prior to incurring costs over and above those allowed for under the terms of this contract. Regardless of contract type, and of work location, Contractors performing work in support of authorized tasks within the scope of their contract shall charge those hours accurately in accordance with the terms of this contract.

2.4 Quality Control Plan

The Contractor shall develop a Quality Control Plan (QCP). A draft QCP will initially be submitted with the Offeror’s proposal. The QCP shall document how the Contractor will meet and comply with the quality standards established in this Performance Work Statement. At a minimum, the QCP must include the Contractor’s objectives for animal care (health and psychological well-being); management of the reproductive NHPs and providing for the number of progeny necessary to meet the needs of the Government. Additionally the QCP shall include a self-inspection plan, an internal staffing plan, and an outline of the procedures that the Contractor will use to maintain quality, reporting accuracy, timeliness, responsiveness, data management, customer satisfaction, and any other requirements set forth in this solicitation.

2.5 RESERVED

2.6 Animal Husbandry and Veterinary Care Services

The Contractor shall provide qualified personnel to provide husbandry and veterinary care for the NHP 7 days a week, 24 hours per day, and 365 days a year. Personnel must have experience in the operation and management of a non-human primate breeding colony. Per Diem charges will begin once NHPs reach 7 months of age. All NHPs shall be individually marked by tattoo across the chest at the time of weaning or acquisition if not already marked.

The tattoo shall serve as the animal’s individual identification number. Weaned NHPs will be regrouped with other conspecifics of the same age and gender.

2.6.1 Animal Health Maintenance

The Contractor will provide on-site veterinary care to include, but not limited to, twice daily health observations, 24 hour emergency care, clinical pathology, diagnostic pathology, hospital care and surgical treatment of NHPs. The Contractor shall make every effort to maintain a colony that is SPF for Herpes B Virus, measles, SRV, SIV and STLV-1. Contractor will treat endoparasites and ectoparasites in accordance with current accepted standards of veterinary care. All primates dying unexpectedly shall receive an examination and necropsy to determine the cause of death. The Contractor shall develop, maintain, and operate in accordance with their Standard Operating Procedure (SOP) for animal husbandry, colony maintenance, and all aspects of this contract. The Contractor shall provide the SOP to the Government upon request.

NHPs shall be vaccinated against measles at the discretion of the Government. The Government may change the testing frequency as necessary.At a minimum, routine annual colony screening shall include the following and shall be included in the per diem charge:

・ Serological testing for Herpes B, measles, SRV, SIV and STLV

・ Polymerase Chain Reaction (PCR) or Cell Culture for SRV is required annually for all NHPs

・ TB testing

The number of tests/diagnostics in the current year in Table 1 are provided to give the Contractor a means of estimating future needs based upon current actuals. These tests are currently performed semiannually for NHPs less than or equal to 3 years and annually for NHPs greater than 3 years. Table 1 reflects this frequency. Additional diagnostics and those not listed above shall be identified and awarded under separate task orders.

TABLE 1: Average Diagnostics

Viral Profile (B-virus, SRV, STLV-1, SIV)

SRV PCR (SRV 1,2,3,4 and 5)

Average # Panels 464 335

2.6.2 Animal Breeding

The Contractor shall provide a draft Animal Breeding Plan / Report with proposal submission detailing its plan to achieve to provide at least 50 RN 2.5-3 year old, >3.5 Kg SPF IO rhesus macaques per year. The Contractor shall make reasonable strides towards reaching a 70% production rate, or if infant loss rate/adult mortality rate rises or exceeds the contract standard, Contractor will promptly notify COR. Any changes in husbandry and/or breeding practices must be approved by COR prior to implementation. Successful achievement of these standards will be utilized in annual Contractor reviews and in the decision making process to exercise subsequent option years.

2.6.3 Animal Surge

The Contractor shall be able to accommodate a surge of up to 200 additional NHPs as required by the Government.

2.7 Data Management

The Contractor will maintain a digital system of records to store, analyze and display data on all past and present NHPs of the colony for the duration of the contract. The Contractor shall establish and maintain a copy of animal records on the designated WRAIR digital record keeping system. Both a primary and secondary individual shall be designated and granted access to the WRAIR digital record keeping system. The Contractor identified employees shall be issued a Common Access Card (CAC), undergo a background screening, be required to complete all required training to maintain access to the network. Contractor identified employees shall log into the WRAIR network no less than once monthly to maintain access. The Contractor shall file and maintain vendor animal health reports, keeping information available for all current research protocols. The system of records shall reflect:

・ Individual Identification number

・ Sire’s and Dam’s Individual Identification Numbers if known

・ Birthdate

・ Gender

・ Offspring, when applicable, to include stillbirths:

o by Individual Identification Number;

o gender;

o date of birth;

o birth weight;

o hospitalizations and cause;

o date of death;

o sire’s Individual Identification Number

・ Health Status (e.g. herpes +, SIV +, in hospital)

・ Hospitalizations and cause

・ Specific location within facility

・ Disposition, when applicable, to include date and cause

・ Behaviorally related incidents

2.7.1 Monthly Activities Report (MAR)

A Monthly Activities Report (MAR) describing progress of the animal husbandry/maintenance program to date, noting all technical areas in which effort is being directed and indicating the status of work within these areas will be furnished to the COR for review and acceptance. The COR will review each Monthly Activities Report to ensure the Contractor is making progress towards achieving the stated objectives.

These reports shall include data regarding:

• Colony activities

• Morbidity

• Mortality

• Culls due to Chronic Disease

• Testing

• Inventory by gender and year reflecting the Monthly Colony Census results

• Previous Monthly Colony Census total colony population

• Deaths

• Live births

• All other acquisitions and/or dispositions

• Current Monthly Colony Census total colony population

• Total number of all infants <7 months old

• Current Monthly Colony Census total population for which per diem applies.

• Breeding Animal inventory by sex and year of birth

• Replacement Breeding NHPs/Available for Research by sex and year of birth o Production rate o Infant loss rate o Adult mortality rate

2.7.2 Monthly Colony Census

The Contractor shall conduct a Monthly Colony Census and shall provide a Monthly Colony Censur Report. The system of records shall be updated monthly to reflect the results of the respective census. The Monthly Colony Census data must reflect:

• Number of dead NHPs by gender, age and date of death for current month

• Number of births by gender and date of birth for current month

• All other acquisitions or dispositions for current month

• Monthly Colony Census total population

• Number of all male NHPs organized by year of birth

• Number of male infants <7 months old

• Number of all female NHPs organized by year of birth

• Number of female infants <7 months old

• Number of still-births o Production rate o Infant loss rate o Adult mortality rate

2.7.3 Reproductive Cull Report

Contractor shall provide a reproductive cull report identifying NHPs not suitable for breeding to the COR on an annual basis or upon Government’s request.

2.7.4 Miscellaneous Data Reports

Miscellaneous reports covering colony maintenance, husbandry data, health status, protocol use, or contract administrative reports, not otherwise addressed, be held separately while under quarantine for a minimum of 10 days before transportation unless waived by the Government. During quarantine, NHPs will be tuberculin tested twice, and receive a broad spectrum antihelmintic colony maintenance, husbandry data, health status, protocol use, or contract administrative reports, not otherwise addressed, may be requested by the Government and must be provided within 20 days. It is expected that no more than 3 miscellaneous reports per quarter will be requested.

2.8 Personnel

2.8.1 Occupational Health and Safety Program (OHSP) requirements. The Contractor shall maintain an OHSP program and insure contract performance in accordance with OSHP requirements and other federal requirements.

The Contractor will insure its employees obtain medical clearance and are cleared to perform on this contract. The Contractor shall provide evidence of medical clearance upon request.

2.8.2 The Contractor shall provide their staff with all personal protective equipment (PPE), to include but not limited to safety shoes, gloves, and protective clothing and prescription safety glasses. The Contractor shall be responsible for proper cleaning/disinfecting of all reusable personal protective equipment. The Contractor is responsible for providing uniforms to all Contractor personnel.

2.8.3 Training Requirements. The Contractor shall provide personnel trained in a manner that is consistent with AAALAC standards. The Contractor shall maintain a documented training program for its personnel. Evidence of training program and employee documentation of training shall be made available upon Government request. Some general categories of training shall include, but are not limited to, humane care and ethical use of NHPs, animal care and veterinary medicine, animal husbandry techniques, animal handling and restraint, operation of service equipment, and safety.

2.8.4 The Contractor shall screen prospective employees and maintain proactive security monitoring of employees to protect the facility from entities with intent to damage or disrupt colony operations.

2.8.5 The Contractor shall be responsible for instructing new employees in all safety measures necessary for the worksite prior to beginning any work. The Contractor shall provide his/her employees with training on the special environment of the animal facilities such as 1) the presence of hazardous agents (e.g., zoonotic organisms, biohazards, carcinogens, toxic chemicals, radiation and radioactive materials), 2) adherence to all facility operating procedures to prevent contamination and cross-contamination and 3) all other topics necessary to properly perform the work described in this contract. The Contractor shall provide said training on a continuing basis and shall maintain documentation including the name of each attendant and the date training was received. All costs and expenses of training Contractor personnel shall be the responsibility of the Contractor.

2.9 Facilities

The Contractor shall provide secure, licensed and accredited NHP facilities which are certified and maintained in accordance with DoD, federal, state, and local regulations and industry standards to include AAALAC, USDA, PHS policy, Animal Welfare Act and standards described in The Guide for the Care and Use of Laboratory Animals, 8th edition. The facility must maintain its accreditation and licensure status for the duration of the contract. The facilities and equipment shall be of sufficient size, strength, safety, durability and ability to be sanitized to house NHPs while providing a psychologically enriching environment to the NHPs. Facilities and equipment shall be maintained in accordance with industry standards. The Contractor shall verify the efficacy of the sanitation and disinfection activities, the feed, bedding, water quality and environmental monitoring, treatment regimes, breeding practices and any other procedure which is suspected to impact colony health in order to ensure that NHPs remain healthy and pathogen free and subclinical disease agents are identified.

2.9.1 Visitation Program Policy

Contractor shall establish and maintain a written health certification program and policy concerning all COR approved visitors, staff, and guest investigators working at or visiting the breeding colony, and maintain updated records on all such individuals. Visitors shall wear dedicated shoes and clothing, as provided by the Contractor, while on the premises. Contractor shall maintain a registry of all visitors to the colony. The registry shall contain the visitor’s name, dates and time of visit and business address. This program shall be in effect for the duration of the contract. Enforcement and maintenance of the health certification policy for visitors and staff is the responsibility of the Contractor. The Contractor shall provide evidence of an active visitation program, registry, and proof of visitor Tuberculin screening upon request. The certification policy shall require written proof of the following health requirements:

・ Negative tuberculin test, interferon-gamma release assays and / or chest x-ray within 6 months of exposureto colony.

・ Visitors and staff exposed to the colony must be in good health with no signs or declarations of respiratorydisease, gastrointestinal dysfunction, or cold sores.

・ No contact with other NHPs 24 hrs. prior to visiting.

2.9.2 Security

The Contractor shall provide adequate and appropriate physical, cyber and informational security to protect the facility, its NHPs, its employees and its information from entities with intent to damage or disrupt colony operations.

The Contractor’s physical security shall include restriction of photos and videos of its facilities.

2.9.3 Computer and Network Security

All Contractor employees with access to a Government information system must be registered in the Army Training and Certification Tracking System (ATCTS) at commencement of services and must successfully complete the DoD Information Assurance (IA) Awareness training prior to access to the information system and annually thereafter.

The Contractor shall ensure authorized access to, and protection of, issued Government property to include laptop and CAC card issued for use in the performance of the contract.

Remote access will be maintained by the Contractor using VPN, Citrix, or other Department of Defense (DoD) approved application. A computer system will be made available to the Contractor as required for off-site database entry. The Contractor shall be responsible for providing limited, external preventive maintenance of this equipment (i.e., keeping equipment clean and dust- and static-free).

2.9.4 Public Key Infrastructure Authentication and Encryption

Contractors shall follow the DoD standards, policies, and procedures related to the use of Public Key Infrastructure (PKI) certificates and biometrics for positive authentication including authentication to DoD private web servers or applications. Where interoperable PKI is required for the exchange of unclassified information, including the encryption of e-mail containing sensitive information, between DoD and its Contractors, industry partners shall obtain all necessary certificates if they are not eligible for a DoD Common Access Card. (refer to https://iase.disa.mil/pki/eca/).

2.10 Animal Delivery

As needed and directed by the COR, the Contractor shall deliver SPF IO rhesus macaques under separately issued task orders. The Government will determine the quantity of NHPs, time, and site of delivery. The Contractor shall provide the expertise and the mechanisms of shipment. Upon receipt of appropriate instructions from the Government, the Contractor shall coordinate the shipment to include transport caging and carrier. The Contractor shall comply with all current federal, state and local requirements for the shipment of NHPs. NHPs shall be delivered in properly ventilated, escape-proof cages furnished by the Contractor. Each compartmentalized cage shall have separate water and feed containers for each compartment. Cages shall be in accordance with the USDA and International Air Transport Association (IATA) guidelines as applicable.

The Contractor shall, under a separately awarded task order, provide biological samples for pre-screening of NHPs prior to shipment. Each shipment of NHPs shall as agreed upon by COR and the Contractor. All NHPs will have serology submitted for Herpes B virus, measles, Simian Retrovirus Type D (SRV), Simian T-cell Leukemia Virus (STLV), Simian Immunodeficiency Virus (SIV) within three (3) months of delivery. Average diagnostic information is available in Table 1of Section 2.6.1 for viral profile and SRV testing. Only seronegative NHPs will be shipped to the Government, unless the COR otherwise approves.

2.11 RESERVED

2.12 Animal Acquisition (Purchase) and Disposition (Sale)

2.12.1.1 Upon Government request, the Contractor shall purchase any of the following NHPs: IO rhesus macaques, Chinese origin rhesus macaques and cynomolgus macaques. Additional costs due to specific research requirements shall be included in the purchase price of the animal. Final purchase price shall include any necessary diagnostics and quarantine periods. Shipping and crating shall be separately priced.

2.12.1.2 The Government may direct the contractor to sell Government-owned NHPs. The COR will identify any excess NHPs eligible for sale following fulfillment of research and breeding needs. The Government must approve the purchaser following review of requested documentation described below. The contractor may propose an administrative fee for their services in support of selling Government-owned NHPs. Shipping shall be paid by the purchaser. Any proceeds from the sale of Government-owned NHPs above costs to sell, transport NHPs, and contractor a fee, shall be credited back to the Government on the animal husbandry and maintenance contract.

2.12.1.3 Separate task orders shall be awarded for the purchase of new NHPs and the sale of Government-owned NHPs.

2.12.1.3.1 For acquisition of NHPs, the price of the animals will include the cost of the animal, testing, transportation, transportation crates and surgical services (if required).

2.12.1.3.2 For brokering the sale of our NHPs, the price of the animals will include the cost of the animals plus an administrative fee proposed by the Contractor for services. The cost of testing, transportation, transportation crates and surgical services will be incurred by the buyer.

2.12.2 Market Value Report

The Contractor shall provide a report detailing market value for IO rhesus macaques, Chinese origin rhesus macaques and cynomolgus macaques. This report, along with other pertinent information, will be used to provide price information in the event NHPs need to be purchased.

2.12.3 Animal Source Information

The Contractor will provide supplier information to the COR, if requested, prior to animal purchase. This information may include but is not limited to: copy of any licensing (USDA) and or accreditation status (AAALAC) documentation, description of animal housing and husbandry to include veterinary care, and animal health records.

2.12.4 Report of Interested Buyers

Once potential buyers are identified, Contractor shall provide the COR with buyer information, to include but not limited to: accreditation status, licensing (USDA), animal housing, and proposed use of animal. Contractor shall also include a quote detailing a breakdown of all costs associated with the sale to include any shipping costs and diagnostics charges. The Government retains the right to have final authority for sale of any identified Government owned NHPs.

2.12.5 Sale Documentation

Following approval of sale by COR, Contractor shall provide a copy of all final sale documentation, transfer of ownership documentation, and confirm final shipment and receipt of NHPs.

3.0 INSPECTION AND ACCEPTANCE

The COR is a Government official who has been delegated specific technical, functional and oversight responsibilities for this contract and the resultant task orders issued under this award. The COR is designated in the COR appointment letter issued by the Contracting Officer, and is responsible for inspection and acceptance of all services, incoming shipments, and documents..

3.1 Acceptance Criteria

The Government’s Certification of satisfactory services is contingent upon the Contractor performing in accordance with the performance standards contained in the Performance Requirements Summary Matrix (Section 6.2) and all terms and conditions of this award, including all modifications.

3.2 Contractor Payment Processing

The Contractor is responsible for properly preparing and forwarding to the appropriate Government official, the invoice and receiving report for payment. The Contractor shall invoice in accordance with DFARS clause 252.232- 7006 of the task order. The Contractor shall attach back up information to receiving reports for direct labor and ODCs. Backup information for ODCs shall list all elements of costs, such as travel breakout, including itinerary, dates of travel, name of employees traveling plus per diem costs shall accompany the receiving report.

4.0 OTHER DIRECT COSTS (ODCs)

All ODCs exceeding $3,000 requires that the Contractor conduct appropriate competition. The Wide Area Workflow – Receipt and Acceptance application is the required method of submission for payment request.

4.1.1 Travel

Arrangements for and costs of all travel, transportation, meals, lodging, and incidentals are the responsibility of the Contractor. Travel costs shall be incurred and billed in accordance with FAR Part 31. Costs for these expenses will be reviewed, certified as approved by the COR. All travel and transportation shall utilize commercial sources and carriers provided the method used for the appropriate geographical area results in reasonable charges to the government. The Government will not pay for business class or first-class travel. Lodging and meals shall be reimbursed in accordance with regulations defined in FAR PART 31. The Contractor shall submit for approval a cost estimate of the travel to be accomplished not later than 5 business days prior to travel being conducted.

The Contractor shall provide two employees for the required training in order to be issued a CAC. Additional personnel may be sent for training and to have a CAC issued at Contractors expense. Government shall pay for additional travel should the CAC holder need re-credentialing due to laptop failure, additional training, or to meet other Government CAC holder requirements. Estimated annual travel is indicated below:

To Round Trip (Y/N)

# of Trips # of People # of Days

Contractor Facility Silver Spring, MD Y 1 2 5

Travel Estimate is approximately $6,700 per year.

4.1.2 ODCs

The ODCs shall be billed on a cost reimbursable basis. Costs are defined as the purchase price of materials or service plus General and Administrative charges (G&A) or material and handling charges (M&H). All ODCs shall be fully supported in compliance with all competition requirements of the FAR PART 19. All ODCs shall be reported as stated in the Monthly Financial Progress Report Section 2.1.1.

ODCs may be attributable to a surge requirement of additional NHPs. Estimated additional ODCs are as follows:

Crating material not to exceed $44,000 annually.

Shipping Mileage or flat rate – annual estimate - $40,000

5.0 PLACE OF PERFORMANCE:

Daily operation and colony maintenance tasks will take place at the Contractor’s facility.

5.1 Work Schedule

The Contractor shall provide staffing necessary to provide support and care for NHPs 365 days/year, 24 hours/day, 7 days/week.

6.0 QUALITY ASSURANCE

The Government will review Monthly Progress Reports and will attend regular task performance review meetings with the Contractor to survey quality of services.