SSN - DRAGEN GCP Level 4 Service License.pdf

SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95024Q00391

2. Title: DRAGEN GCP Level 4 Service License

3. Classification Code: 7A21 – IT and Telecom – Business Application

Software (Perpetual License Software)

4. Description:

This is NOT a solicitation for proposals, proposal of abstracts or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses (e.g., 8(a), Veteran-owned small businesses, service-disabled Veteran-owned small businesses, HUBZone small businesses, small disadvantaged businesses, and women-owned small businesses); and (3) their size classification relative to the North American Industry

Classification System (NAICS) code for the proposed acquisition. Your response to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for market research and information purposes only. Furthermore, it should be noted that any future solicitations that may be issued as a result of this notice, or in response to this requirement, may be issued using a different solicitation number from the one identified above.

Background: The Neurodegenerative Diseases Research Section (NDRS) is a leading neurogenomics laboratory that specializes in applying modern gene discovery applications to understudied neurodegenerative diseases, such as Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis. NDRS's success rests on its ability to generate and analyze high-quality genome data from patients suffering from these fatal diseases. The laboratory has already generated genome data from 10,000 people using the Illumina X10 sequencing platform. These raw genome data must be processed on the Illumina DRAGEN platform to be usable for gene discovery analyses.

The Illumina DRAGEN (Dynamic Read Analysis for GENomics) platform is a sophisticated system that analyzes next-generation sequencing data from Illumina sequencers. This versatile platform integrates optimized algorithms to process genomic data with high accuracy. The system is designed to be scalable, so thousands of genomes can be rapidly processed. The DRAGEN platform will perform graph-based alignment of the raw sequence data files to the human reference genome (hg38) and apply highly optimized algorithms for accurate and scalable joint variant calling. These alignment data will then be used for the accurate genome-wide detection of single nucleotide variants, structural variants, copy number variants, repeat expansions, and variants in targeted regions (e.g., HLA locus, GBA locus) using advanced algorithms that are readily incorporated in the DRAGEN platform.

Purpose and Objectives: The purpose of this acquisition is to purchase access to the

Illumina DRAGEN (Dynamic Read Analysis for GENomics) platform. This platform is a proprietary suite of advanced algorithms designed to accurately detect variants in human genome data.

Project requirements: The Contractor shall provide one (1) Illumina DRAGEN GCP

Level 4 Service License with the following specifications:

All deliverables required under this contract shall be packaged, marked, and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition.

Delivery Date: 3 months after receipt of order

Warranty: One year warranty on all parts electrical and mechanical.

Capability statement /information sought.

Companies that believe they possess the capabilities to provide the required products or services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor

GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the

Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of

Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

Interested companies are required to identify their type of business, applicable North

American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice.

However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number.

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested.

All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted.

The response must be submitted to Scott Duernberger, Contract Specialist at e-mail address scott.duernberger@nih.gov.

The response must be received on or before 3:00pm Eastern Time July 3, 2024.

“Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The

Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the

Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”