PWS_Aviana_.pdf

NAVAL MEDICAL RESEARCH UNIT SAN ANTONIO

PERFORMANCE WORK STATEMENT

Service Contract and Preventative Maintenance for the surface acoustic wave (SAW) biosensor

1. Scope of Work

The command mission of Naval Medical Research Unit San Antonio (NAMRU-SA) is to conduct gap-driven combat casualty care, craniofacial, and directed energy research to improve survival, operational readiness, and safety of DoD personnel engaged in routine and expeditionary operations. To accomplish this mission, NAMRU-SA will combine surface acoustic wave (SAW) technology and phage display technique (PDT) to establish a novel method for developing diagnostics against the influenza virus, which is notorious for its rapid mutations, making it difficult to develop diagnostic antibodies against. We aim to produce a diagnostic instrument that provides results in seconds and is portable, inexpensive, and rugged, with minimal development time. Our objectives are to produce small peptides that act as stable molecular recognition substances using PDT and apply them on SAW technology to detect the influenza virus. This approach will also be expanded to detect the COVID-19 virus.

2. Definitions and Terms

N/A

3. Support Requirements

1. Delivery of technical and manufacturing/fabrication support in pursuit of a surface acoustic wave (SAW) biosensor coupled with phage display technology.

2. Production of an initial report on the current status of company platform with supporting data as it relates to the virus detection using recognition antibodies:

a. Improvement of sensor design with liquid-proof protection and capacitive coupling

b. Biomolecular coating development

c. Preanalytical processing development for clinical specimens

d. Data demonstrating the ability to detect virus in buffer and clinical matrix

e. Considerations for process scale-up: sensor functionalization, optimization, and packaging

3. Develop biomolecular coating with anti-influenza A peptides and generate a standard curve using different titers of influenza virus load in buffered solution.

4. Test influenza virus infused into nasal swab samples to optimize and determine the sensitivity and selectivity of the assay.

3.1. Storage and Transport Requirements

3.2. Analysis and Reporting Requirements

The vendor will provide research updates as requested.

4. Additional Requirements/Qualifications

5. Delivery Address Naval Medical Research Unit – San Antonio

NAVAL MEDICAL RESEARCH UNIT SAN ANTONIO

PERFORMANCE WORK STATEMENT

3650 Chambers Pass, Bldg 3610 JBSA Fort Sam Houston, TX 78234 Phone: 210-539-7866

6. Contract Period of Performance The period of performance will be 12 months.

7. Points of Contact

Technical POC Yoon Hwang, Ph.D.

Phone: 210-539-6263 Email: yoon.y.hwang.mil@mail.mil

Contract POC Mr. Michael Simonoff Phone: (210) 539-6252 Email: michael.simonoff.civ@mail.mil