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This document is a Notice of Funding Opportunity (NOFO) for the Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) grant opportunity.

The NOFO is issued by the National Institutes of Health (NIH) under the Mental Health Research Grants (CFDA 93.242) program. It seeks applications for pilot effectiveness projects to evaluate therapeutic and service delivery interventions for the post-acute management of mental health conditions. The grant will support research to assess the feasibility, tolerability, acceptability, safety, and potential effectiveness of these interventions, as well as whether they engage the target mechanisms. Eligible applicants include tribal governments, non-profits, for-profit organizations, small businesses, state/local governments, and higher education institutions. Grant awards will support pilot-scale effectiveness trials as a precursor to larger-scale definitive effectiveness studies. The NOFO provides details on the research focus, applicant eligibility, award information, and application process.