Purchase_Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The NIH Mouse Imaging Facility (MIF) needs a new high resolution ex-vivo Micro Computed Tomography (microCT) imager to replace the current scanner. The current scanner is no longer supported by the manufacturer. The scanner is required to capture extremely high resolution radiographic images of very small samples such as mouse teeth and bones, zebrafish and fruit flies. In the past five (5) years twelve (12) different NIH institutes have used the current ex-vivo microCT scanner and almost every institute has imaged tissue samples over its usage history. The ex-vivo microCT continues to be a MIF imaging resource in high demand.

2. Background Information and Objective:

The NIH Mouse Imaging Facility (MIF) is a shared, intramural resource for preclinical animal imaging studies. The MIF provides the NIH intramural research community access to modern radiological imaging equipment optimized for rodents and other laboratory animals for noninvasive imaging studies. The MIF provides intellectual, technical and material support for NIH investigators. MIF imaging resources include: magnetic resonance imaging (MRI), micro-computed tomography (Micro-CT), high frequency ultrasound with photoacoustic imaging, bioluminescence and fluorescence imaging (optical imaging). The MIF is dedicated to providing state-of-the-art anatomical, functional and molecular medical imaging capabilities for animal models of human disease.

The objective of this acquisition is to obtain a new high resolution ex-vivo micro CT scanner to replace the current one that is no longer supported by the manufacturer.

3. Generic Name of Product: High resolution desktop micro CT scanner (Tissue CT)

4. Purchase Description: high resolution desk-top X-Ray microtomograph with 16 megapixel CCD camera

5. Salient characteristics:

The high resolution desktop microCT imaging system must include a minimum of the following characterstics:

• Scanner shall Include a 16 megapixel 14-bit cooled CCD camera with a minimum three offset positions equaling three times the field of view.

• Equipment shall produce reconstructed volumes up to 209 Megapixel (14450x14450 pixels) virtual slices through objects, more than 2600 such slices after a single scan.

• Equipment must use phase-contrast enhancement to visualize object details as small as 0.35um (minimum pixel size).

• Scanner must contain an acquisition geometry with ability to simultaneously adjust the sample distance and detector distance to the X-ray source automatically. This means that for most scans the sample can be in the Near position, increasing scan

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs speed by 5X. For either the highest resolution scan or the largest samples, the detector moves into the Mid or Far positions.

• Camera shall provide continuous magnification from 0.34um – 25um pixel sizes.

• Scanner shall contain a field of View X-ray Detector for samples up to 75mm in diameter, 70 mm high. Detector has 5000 pixels horizontally and 3280 pixel vertically for large field of view in a single scan. The scanner shall have the capability for reconstruction arrays of 14,450×14,450 (200Mp+ in a single reconstructed image).

• System shall have a maintenance-free X-ray source (20-100kV, 10W) with <5 micron spot size, with automatically variable spot size to conserve X-ray source lifetime.

• Scanner shall have a 6-position automatic filter changer to adjust x-ray energy and energy filtering of X-ray source.

• System shall have unrestricted reconstructed data size limit supported by multithreaded GPU-accelerated 3D-reconstruction and realistic visualization by surface and volume rendering.

• Scanner shall include an integrated micropositioning stage with 5mm travel to achieve exact positioning of small objects in the middle of the scanning area.

• Contractor shall provide a 16-position automatic sample changer to allow the adding, removing, and replacing of samples without interrupting a live scanning process. Automatic magnification adjustment and scanning protocol optimization available for individual samples. At the end of the scan the system sends an e-mail with a direct link to the scanning results, which can be opened across a network.

• System shall provide thermal correction for reconstruction: Pixel Projection Shift Correction (PPSC) is an advanced reconstruction algorithm that corrects for any thermal changes of the X-ray source due to environmental changes.

• Physical footprint not to exceed (1160 mm X 520 mm X 330 mm) for site location

• Scanner must be fully shielded for radiation safety: <1 uSv/h at any point of instrument.

• Contractor Shall include software supplied with unlimited site license with free updates for the life of the instrument.

• Contractor shall provide unlimited phone, email, and online support for the SkyScan instrument for the life of the instrument. (Support for Dell workstation provided in the Dell warranty.)

• Contractor shall provide onsite training on-site for up to 5 people.

6. Quantity: one (1)

7. Delivery Date: ship within 6 months after receipt of order

8. Warranty: Contractor shall warrant the equipment against defects in material or workmanship for a period of 12 months from the date of installation and acceptance.