RFPAmendment_3_-05-19-17_s.pdf

OMB No.: 0990-0115

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

PAGE

OF PAGES

2. AMENDMENT/MODIFICATION NO.

3. EFFECTIVE DATE

05/19/2017

4. REQUISITION/PURCHASE REQ.

NO.

N/A

5. PROJECT NO. (if applicable)

6. ISSUED BY CODE

7. ADMINISTERED BY (If other than Item 5) CODE

National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development Contracts Management Branch

6710B Rockledge Drive

BETHESDA MD 20892

8. NAME AND ADDRESS OF CONTRACTOR (No., street, city, county, State and ZIP Code)

TO ALL POTENTIAL OFFERORS

9A. AMENDMENT OF SOLICITATION NO.

RFP NIH-NICHD-CRB-2017-4

X

9B. DATED (SEE ITEM 11)

04/10/2017

10A. MODIFICATION OF

CONTRACT/ORDER NO.

CODE

FACILITY CODE

10B. DATED (SEE ITEM 13)

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in item 14. The hour and date specified for receipt of Offers is extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning __1___ copy of the amendment in your business proposal; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (if required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO FAR 52.243-2. THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER

NO. IN ITEM 10A.

B.THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b) and Contract ARTICLE B.4.

C.THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D.OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor __ is not, X is required to sign this document and return 1 copy in your business proposal to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: To amend the RFP and to provide clarifications based on inquiries received regarding RFP NIH-NICHD-CRB- 2017-4, entitled, “Chemical Synthesis Facility.”

Except as provided herein, all terms and conditions of the document referenced in item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

16A. NAME AND TITLE OF CONTRACTING OFFICER

Alice Pagán NICHD Contracts Management Branch, NIH

15B. CONTRACTOR/OFFEROR

BY ______________________________________________

(Signature of person authorized to sign)

15C. DATE SIGNED

16B. UNITED STATES OF AMERICA

BY

(Signature of Contracting Officer)

16C.DATE SIGNED

05/19/2017

RFP-NIH-NICHD-CRB-2017-4

AMENDMENT NO.: 003

CONTINUATION PAGE

A. As a result of this Amendment the RFP is revised as follows:

1. Page 35, Section L, Instructions to Offerors, k. AVAILABILITY OF THE "FEDERAL ADP AND

TELECOMMUNICATIONS STANDARDS INDEX" is hereby removed.

B. This Amendment provides answers to questions received regarding this RFP, please note that individual questions may have been combined or reworded. The responses are provided for information only as guidance to potential offerors and do not supersede any terms of the RFP and do not revise or become part of this RFP.

The responses to the inquiries received are as follows:

Question 1: Who is currently holding the present Chemical Synthesis Facility Contract?

Answer 1: Ash Stevens LLC.

Question 2: Should all parts of the project be done at one site, or can it be subcontracted out?

Answer 2: It is the offerors’ decision as to whether they elect to subcontract out part of the work or use another site.

Question 3: In your first RFP you mentioned some of the compounds are peptides as well as steroids, but your latest amendment just steroids, would you clarify?

Answer 3: The contractor maybe asked to synthesize compounds including, but not limited to steroids, steroid analogues, unnatural amino acids, natural products, natural product analogues, heterocycles, and peptides. Please see Technical Evaluation Factors, pages 59-60 of the RFP and Statement of Work, pages 64-66 of the RFP. This answer is provided also to clarify the answer provided in Amendment 2 (5/11/17).

Question 4: Can you clarify what is being required in the last point Section L.1.j. relating to the “Federal ADP and Telecommunication Standards Index.”

Answer: 4: Section L.1.k, p. 35 of the RFP, Availability of the “Federal ADP and Telecommunication Standards Index” is not applicable; therefore, it has been removed from the RFP.

Question 5: Article H.12 describes the Institutional Responsibility Regarding Investigator Financial Conflicts of Interest.

Can you clarify the intent of the directive and the level of response we need to be in compliance?

Answer: 5: This report requires the Contractor to disclose significant financial interest that could directly and significantly affect the design, conduct, or reporting of PHS-funded research. Please refer to the following sections in the RFP:

• Section C, Article C.2. Reporting Requirements, b. Other Reports/Deliverables (pages 6 and 7), 1. Reporting of Financial Conflict of Interest (FCOI). Also, refer to 45 CFR Part 94 at: https://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&SID=0af84ca649a74846f102aaf664da1623&rgn=div5&view=text&node=45:1.0.1.1.51&idno=45

See Part 94.5, Management and reporting of financial conflicts of interest for complete information on reporting requirements.

• ARTICLE H.12. INSTITUTIONAL RESPONSIBILITY REGARDING INVESTIGATOR FINANCIAL

CONFLICTS OF INTEREST, pages 17, and 18 and

• Section L, page 39, item 11. Institutional Responsibility Regarding Investigator Conflicts of Interest.

https://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&SID=0af84ca649a74846f102aaf664da1623&rgn=div5&view=text&node=45:1.0.1.1.51&idno=45 https://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&SID=0af84ca649a74846f102aaf664da1623&rgn=div5&view=text&node=45:1.0.1.1.51&idno=45