Purchase_Description.pdf

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute of Drug Abuse (NIDA), Office of Acquisition (OA) has a requirement for a customized system of radiotranslucent high performance polymer chambers to fit the non-human primate skull and permit chronic and simultaneous neuronal recordings from multiple brain regions. Using permanently implanted electrodes that can be individually adjusted is critical to the scientific goals of this project, which are to understand how activity across brain regions mediates the ability of drug-associated cues to engage cognitive resources.

2. Background Information and Objective:

The mission of the Intramural Research Program (IRP) of the National Institute on Drug Abuse (NIDA) is to conduct state-of-the-art research on basic mechanisms that underlie drug abuse and addiction, and to develop new methods for the treatment of drug abuse and addiction. The National Institute on Drug Abuse (NIDA) seeks the in-house capability to provide design and manufacturing of a customized system of radiotranslucent high performance polymer chambers to fit the non-human primate skull and permit chronic and simultaneous neuronal recordings from multiple brain regions. This is a sealed system that reduces the risk of infections while allowing us to independently collect data from multiple channels over time. The drive systems must position up 220 recording electrodes per subject into multiple brain regions.

3. Generic Name of Product:

Chronic Neural Recording Chamber

4. Purchase Description:

Brand-name or Equal

Brand-name Specific (Item peculiar to one manufacturer)

5. Salient characteristics:

The project requires the following:

• MRI based skull model design for two non-human primate (NHP) subjects.

• Design and manufacture a 157 channel microdrive and 32 channel microdrive for one subject.

• Design and manufacture a 220 channel microdrive for one subject.

• The microdrive assemblies must meet the following specification:

o Assembly must be hermetically sealed after surgical placement.

o Each recording electrode must be individually adjustable for depth.

• Provide all necessary components (holders, bone screws, etc.) for operation of the microdrives.

• Perform necessary loading, testing, and registration of the chambers for both subjects.

6. Quantity:

Item Number Description Manufacture Quantity 0001 Subject 1 – 157 channel microdrive and 32 channel microdrive in accordance with Section 5: Salient Characteristics.

Gray Matter Research LLC

0002 Subject 2 – 220 channel microdrive in accordance with Section 5: Salient Characteristics.

Gray Matter Research LLC

7. Delivery Date:

Delivery shall be within 30 days after receipt of order (ARO) to the following address:

John Johnson National Institute on Drug Abuse (NIDA) 251 Bayview Boulevard, Suite 200 Baltimore, MD 21224 Dock #2 Phone: 443.740.2449 Email: johnsonjr@mail.nih.gov

8. Packaging, Marking and Shipping:

All deliverables shall be packaged and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name.

9. Inspection and Acceptance:

All deliverables shall be inspected for acceptance by the receiving official.

mailto:johnsonjr@mail.nih.gov