N02CN75014-45_Amendment_3_CLARIFICATIONS_EXTENSION.pdf

OMB No 0990-0115

1. CONTRACT ID CODE PAGE OF PAGES

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT N/A 1 11

2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable)

3 March 29, 2018 N/A

6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE N/A National Institutes of Health National Cancer Institute Office of Acquisitions 9609 Medical Center Dr., Rm 1E646, MSC 9705 Bethesda, MD 20892-9705

8. NAME AND ADDRESS OF CONTRACTOR (No. Street, County, State and ZIP: Code) ( ) 9A. AMENDMENT OF SOLICITATION NO.

TO ALL POTENTIAL OFFERORS

N02CN75014-45

9B. DATED (SEE ITEM 11)

Feb. 23, 2018

10A. MODIFICATION OF CONTRACT/ORDER NO.

10B. DATED (SEE ITEM 13)

CODE FACILITY CODE

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers is extended, is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted;

or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and data specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

( ) A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET

FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor is not, is required to sign this document and return 1 copy to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: 1) To provide clarification to questions received March 28, 2018, on RFP N02CN75014-45, “Centralized Chemopreventive Agent Repository and Chemistry Support”, and subsequently revised RFP Attachment 11, Additional Technical Proposal Instructions; 2) To extend the Proposal due date from April 9, 2018; 12:00pm ET to April 18, 2018; 3:00pm ET; 3) To provide Amendment #2 SF 30 page with the correct Amendment number shown in Block 2 (changed from number 1 to number 2)—there are no other changes to Amendment #2.

Deadline for Questions: March 9, 2018; 3:00pm ET (Unchanged)

Proposal Due Date: April 18, 2018; 3:00pm ET (Changed)

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print) 16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

Catherine A. Muir Contracting Officer, PCPSB, OA, NCI, NIH, DHHS

15B. CONTRACTOR/OFFEROR 15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 16C. DATE SIGNED

(Signature of person authorized to sign)

BY __________________________________ ________

(Signature of Contracting Officer)

March 29, 2018

NSN 7540-01-152-8070 30-105 STANDARD FORM 30 (REV. 10-83)

PREVIOUS EDITION UNUSABLE Computer Generated Prescribed by GSA

FAR (48 CFR) 53.243

Solicitation N02CN75014-45 Amendment #3 –Questions/Responses

“Centralized Chemopreventive Agent Repository and Chemistry Support”

Solicitation N02CN75014-45 “Centralized Chemopreventive Agent Repository and Chemistry Support” Amendment #3 –Questions/Responses

1. It is still unclear if offerors are to provide Technical write ups for both the Base SOW, only Sample Task Order 1, or both as the answer to Question 26 refers to the Business Proposal. Please clarify. For reference purposes we note that the Base SOW includes 13 Tasks and is limited to 40 pages (the additional task being the transition out). Sample Task Order 1 includes 12 tasks and is limited to 85 pages (See pages 121 and 122 of the RFP). We have included the question and response for questions 27 and 26 at the end of this email for reference purposes.

The following is the question and response for question 27 (Amendment #2—added for clarity):

Technical Proposal Instructions – Offerors are instructed to submit a detailed work plan indicating how each aspect of the Base and Sample Task Order #1 Statements of Work are to be accomplished. These two Statements of Work are practically identical. Can the Government clarify what the expectation is for addressing the Sample Task Order #1 SOW as compared with addressing the Base SOW since both SOWs are nearly identical?

Response to #27: Please see the response to #26 for information.

The following is the question and response for question 26 (Amendment #2—added for clarity):

Attachment 3 - Statement of Work and Attachment 4-Sample Task Order #1- SOW are almost identical. Are the bidders to submit two separate Proposals? One for just the Sample Task Order #1 with only the Base Year priced?

And the other proposal for the main Attachment 3-SOW that is to price the Base Year and the Option Periods that will provide the budget for the full period of performance?

Response to #26: The cost reimbursement, Sample Task Order #1 is for a Period of Performance of twelve (12) months, with no term options. Its SOW is to include the majority of the IDIQ SOW task areas for pricing purposes. It is anticipated that the Sample Task Order #1 would be the first awarded task order. The Period of Performance for the IDIQ contract will be sixty (60) months base with no term options. Please see revised Attachment #17 for clarification on the business proposal format.

Amendment #3, Response to #1: My apologies for any confusion created. Only one (1) Technical Proposal is to be submitted divided into the Sections described in RFP Attachment #11. Please see revised RFP Attachment #11—"Additional Technical Proposal Instructions” for clarification on the technical proposal format.

2. To enable all the bidders to fully evaluate the answers and have the necessary time to issue and solicit the Vendor and Subcontract community, and especially Small Businesses for updated quotations (and in many instances new quotes) we respectfully request a two-week extension from April 9, 2018 to April 23, 2018. It is respectfully believed that this additional time will enable all bidders to negotiate lower prices, and hence be in a position to offer a lower, more competitively priced offer. Your consideration in this regard is greatly appreciated.

Amendment #3, Response to #2: After re-evaluating the project schedule for this procurement, it can accommodate an extension from April 9, 2018; 12:00pm ET to April 18, 2018; 3:00pm ET. Proposals are now due April 18, 2018; 3:00pm ET.

End of Amendment #3 –Questions/Responses for Solicitation N02CN75014-45

Attachment #11 – Additional Technical Proposal Instructions

RFP N02-CN-75014-45

ATTACHMENT 11 – ADDITIONAL TECHNICAL PROPOSAL INSTRUCTIONS

The following Additional Technical Proposal Instructions reflect the requirements of this Request for Proposal and are meant to provide additional instructions as well as uniform format for technical proposals. The information provided and requested in these instructions should be used as a guide for formatting and preparing the technical proposal. This information is provided in addition to instructions provided in Section L of the Solicitation.

A detailed work plan must be submitted indicating how each aspect of the Base, and Sample Task Order #1 Statements of Work are to be accomplished. Your technical approaches, for the Sections 2 and 3 below, should be in as much detail as you consider necessary to fully explain your proposed technical approaches or method for the Sections 2 and 3 below.

The technical proposal should reflect a clear understanding of the nature of the work being undertaken.

The technical proposal must include information on how the project is to be organized, staffed, and managed to allow evaluation as provided in Section M - Evaluation Factors for Award of this solicitation.

Information should be provided which will demonstrate your understanding and management of important events or tasks.

The Offeror must submit a detailed explanation of the proposed technical approaches for the Sections 2 and 3 below, in conjunction with the tasks to be performed in achieving the project objectives of the Base SOW and all the Sample Task Order #1 SOW’s. An Offeror’s proposals which merely restate the Government’s requirements in each SOW of the Government's scope of work will not be eligible for award.

Offerors are advised to give careful consideration to the Base, and Sample Task Order #1 Statements of Work and all reference material, attachments, the technical evaluation criteria, and the Solicitation as a whole, in the development of their Technical Proposal.

Section L.2.a and L.2.b. of the Solicitation discusses the acceptable minimum requirements for the format and contents. The instructions below should be used, along with Section L. of the Solicitation to format and prepare the Technical Proposal.

Submit one (1) Technical Proposal divided into the Section 1, 2, and 3 listed below. Offerors must adhere to the page limits specified below. Pages that exceed more than the specified limitations for Sections 2, and 3 shall be removed from the proposal and shall not be provided to the reviewers to be read or evaluated. Attachments and Appendices do not count against the page limitations.

PAGE LIMITATIONS FOR SECTION 2 AND 3

Section Technical Proposal Page Limitations 2 Sample Task Order 1 Technical Proposal (To include the entirety of RFP Attachment #4) 85-Page Limit

3 Base Technical Proposal (All Task Areas) (To include ONLY Task Area #13 of RFP Attachment #3)

20 40-Page Limit

Offerors are strongly encouraged to organize and submit the Technical Proposal in the following order and as noted below, separating the sections with a page that indicates the section number.

SECTIONS DISCUSSIONS,

INFORMATION,

ATTACHMENTS,

APPENDICES

PAGE

LIMITATIONS

INSTRUCTIONS

SECTION 1

Technical Proposal

Cover Page Does not count against Page limitation

N/A

Table of Contents Does not count against Page limitation

Include page number in TOC for each Section and Discussion, Information

Proposal Summary and Data Record

(NIH-2043)

Does not count against Page limitation

Refer to Section J for link to the form. Do not include SSN number on the form

SECTION 2 - Sample Task Order #1 Technical Discussion

85-page limitation

Refer to Sample Task Order #1 Statement of Work Attachment 4 to the Solicitation

Technical Approach Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Personnel Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Facilities Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Organizational Experience

Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

ATTACHMENTS

AND APPENDICES

These following documents do not count toward the 85-page limitation

N/A

Staffing Plan – Sample Task Order #1

Scored as part of Technical Approach to Sample Task Order #1 SOW; Refer to Section M.

Technical Approach in the Solicitation

Subcontractor Commitment Letters (as applicable)

See below

Subcontractor Technical Proposal

Refer to RFP SECTION L.

TECHNICAL PROPOSAL

(as applicable) INSTRUCITONS, and SECTION M. TECHNICAL CRITERION, and see below

Resumes, CVs Scored as part of Personnel to Sample Task Order A SOW; Refer to Sections L Technical Proposal Instructions and M. Technical Criterion of the Solicitation and see below

Other Considerations Refer Section L.2.b.2. of the Solicitation and see below and see below

Technical Proposal Cost Summary – Sample Task Order #1

Use Attachment located in Section J.

SECTION 3 -Base Technical Discussion 20 40-page limitation Refer to Base Statement of Work Attachment 3 to the Solicitation.

Include discussion.

Technical Approach Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Personnel Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Facilities Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

Organizational Experience

Refer to Sections L Technical Proposal Instructions and M.

Technical Criterion of the Solicitation and see below

ATTACHMENTS

and

APPENDICES

The following documents do Does not count towards the against 20 40-- Page Limitation

N/A

Staffing Plan Scored as part of Technical Approach to Base SOW; Refer to Section M., Technical Approach of the Solicitation; and see below

Resumes, CVs, Scored as part of Personnel approach to Base SOW; Submit for all Named Personnel; Refer to Section L.2.b; see below

Subcontractors (if See below applicable) including commitment letters

Other Considerations Refer Section L.2.b.2. of the Solicitation and see below and see below

GENERAL INSTRUCTIONS:

A. The Offeror’s Technical Proposal encompasses technical discussion of Base and Sample Task Order #1 will be scored in accordance with Section M of the Solicitation. Scored Technical Evaluation Factors include: Technical Approach, Personnel, Facilities, and Organizational Experience, and Transition Plan.

B. Non-scored proposal factors are important to the overall contract award decision. All non-scored proposal attributes must be determined to be minimally acceptable. These must be addressed in the Base and Sample Task Order #1Technical Proposals. Discussion should be specific to address the respective Statements of Work.

C. All proposal information and documentation required as specified in the Solicitation should be included and listed in the Table of Contents with a page reference.

D. Offerors who propose subcontracts to perform portions of the Base +/or Sample Task Order #1 Statement of Work (SOWs) should clearly identify the specific task areas for which they plan to utilize subcontractors, as well as the method and level of integration between the prime and subcontractor(s), and the expected advantages of such an approach. If the proposed approach will involve a subcontracting arrangement, similar technical information must be provided in the Technical Proposal as that required for the Offeror, i.e., technical approach, methods, experience, personnel qualifications, facilities, resources, etc. The relationship between the proposed subcontractor and the Offeror must be clearly delineated.

E. The Government shall use the Offeror’s Technical Proposal to assess the Technical Approach, Personnel, Organizational Experience and Capabilities and Resources and Facilities. Offerors are apprised that for the evaluation under each technical evaluation factor, the Government shall confine its consideration to the section of an Offeror’s proposal that corresponds to that technical evaluation factor. Therefore, in the technical proposal, the Offeror should clearly mark each section to correspond with each technical evaluation factor, and ensure that all information which the Offeror wants the Government to consider for that technical evaluation factor is within the designated section, or, in the case of any attachments, is clearly referenced as incorporated into the correct section. Failure to do so means that the inappropriately placed information may not be considered under the technical evaluation factor.

F. No hardcopies are due. The proposal shall be submitted electronically using the Electronic Contract Proposal System (eCPS). Refer to Attachment 1 Packaging and Delivery of the Proposal for Use with eCPS for instructions.

SPECIFIC INSTRUCTIONS:

The Offeror is responsible for ensuring that all required information and documentation is included in their Technical Proposal in accordance with the Solicitation. The following is additional information and does not include all required information and documentation for the technical proposal.

SECTION 1:

The following does not count toward the page limitations:

a. PROPOSAL TITLE PAGE. Include RFP title and number, name of organization, DUNS number, identification of the proposal part, appropriate titles and signatures of the Business Official and Principal Investigator.

b. PROPOSAL SUMMARY AND DATA RECORD (NIH-2043); Do not include any Social Security Numbers (SSNs) on the form.

c. TABLE OF CONTENTS. Include a Table of Contents (TOC) that provides the page number of each proposal section that at a minimum uses the headings and subheadings that appear in the chart above. Additional subheadings may be entered at the Offeror’s discretion. Refer to Other considerations within Section L of the Solicitation.

SECTIONS 2 -3:

The Offeror should include the Technical Discussions in the relevant section of the Technical Proposal and ensure that the Offeror’s Technical Proposal addresses all required information and documentation in accordance with Section L.2.b. Technical Proposal Instructions of the Solicitation.

The Offeror must separate Technical Discussions for each SOW as per the chart above. Refer to Section M for Technical Evaluation Factors. The following factor and sub-factor weights correspond to Section M.

1. Technical Approach

a. Describe its experience of Repository operations including details of the type of environmental storage equipment used (e.g. freezers, refrigerators, etc.), approaches to monitoring and testing equipment, preventative maintenance schedules, back-up supplies, emergency response plans, etc. Discuss the approach to responding to emergency situations in the repository.

b. Describe how the proposed Key Personnel proposes to communicate, coordinate, and interact with the NCI Contracting Officer’s Representative (COR) and the NCI Contracting Officer concerning the monitoring and management of the base contract and its task orders.

c. Describe its experience and approach to preclinical and clinical study support.

d. Describe its experience and procedures for delivery of materials and services listed in the RFP.

Discuss its experience with shipping and working with third party transport carriers, e.g.

coordination of replenishing shipping coolant during transport, etc. Discuss the approach to responding to problems that arise during shipping of biomaterials.

e. Describe approach for inventory management including the Offeror’s experience in using a relational database for biological specimen inventory management. Provide details of Quality Assurance/Quality Control procedures used in all phases of the operations of a repository, providing laboratory services described in the SOWs, and establishment of subcontracts.

f. Describe proposed approach to the establishing, selection, and coordination of potential subcontractors.

g. Provide copies of Standard Operating Procedures related to the task areas in the SOWs, if available

h. Provide a plan for project organization, staffing, and management in relation to the implementation, optimizing timely performance, monitoring, and completion of the tasks identified in the SOWs.

i. Describe transition plan(s) for assuming responsibility of support activities currently being provided to the NCI DCP via the current contract. Specifically, the plan(s) is (are) to account for coordination efforts required by all Stakeholders for the transfer, receipt and taking over the inventory of the specimens and samples from their present location. The plan should include an indication of the time needed for phase-in.

k. Describe transition plan(s) for the efficient and successful transfer of responsibilities to a potential successor at the end of the proposed contract. Specifically, the plan(s) is (are) to account for coordination efforts required by all Stakeholders for the transfer of the inventory of the specimens and samples to their next location. Describe the plan(s) for the shipment and receipt of the specimens and samples to and from one facility to another. The plan should include an indication of the time needed for phase-out.

2. Personnel

a. Provide the availability and percentage dedication of each personnel proposed, and provide letters of intent if they are not a current employee.

b. Provide each person's proposed responsibilities. Also, describe the recent work history and pertinent technical, scientific, managerial and business credentials of the Key Personnel and other scientific personnel.

3. Facilities

Provide details on maintaining a biospecimen processing laboratory and repository according to industry best practices, as appropriate, and maintaining a safety and health program for good laboratory practices for handling the biomaterials stated in the RFP for the work to be performed. The details are to address the following components:

a. Compliance with all fire and safety requirements required by the state, county, and municipality in which the site is located

b. Inert gas fire suppression system

c. Alarmed and secure storage areas

d. Separate office, pre-clinical, clinical, laboratory, quarantine, storage and shipping/receiving areas

e. Adequate analytical instrumentation installed and operational

4. Organizational Experience

a. Provide examples of previous recent project implementation and management experience, including organizational hierarchy and management oversight. The examples should address implementing and managing all contract activities, including project management systems and procedures for assessing the efficiency of internal project management procedures in the following areas: (i) internal timelines for planning and implementing contract assignments and metrics for assessing efficiency and timeliness; (ii) personnel and other resources required and methods to assess the adequacy of contract resources; (iii) project risks and risk management/mitigation strategies; (iv) initial and ongoing training of technical and project management staff on Project Implementation and Management procedures and timelines; and

(v) procedures to ensure that all Contractor and subcontractor staff safeguard intellectual property, the confidentiality of human subjects and other data, and other information provided by third parties or by the Government, as well as data generated through this contract.

b. Provide examples of previous recent experience in the operation of a secure, climate controlled biological specimen repository, and operation of a laboratory related to the task areas of the SOWs.

c. Provide examples of relevant corporate plans for using data management and tracking systems across projects that could be applied to the base contract and task orders. The examples should describe an approach to minimizing errors in deliverables. Include in this description the measures that the Offeror has used to minimize errors, and the policy on changes to work if it had to be produced a second time due to errors in the initial deliverable.

Transition In (Successor Contractor)

The Offeror shall provide a transition plan that addresses all logistical aspects of material moving and electronic record transfer supporting a smooth transfer of responsibility for the project from the Incumbent Contractor. The following areas should be documented:

1. Availability of transport vehicles and movers trained in hazardous materials

2. Any interim plans to ensure continuity of service

3. Packaging and transport of sensitive materials requiring specialized environments

4. Estimated time for physical move and set-up

5. Estimated cost of the move

6. Inventory reconciliation

7. Replacement of damaged goods

8. Compatibility of electronic platforms and any patches anticipated

9. Any specialized software needed

10. Fidelity of file transfer

11. Estimated time and cost for file transfer

The awardee Contractor and Incumbent shall cooperate to ensure there is no break in continuity of repository services. The awardee Contractor must have full operational capacity at the time of award.

Overall Technical Responsibilities

The Offeror shall describe approaches to the following:

1. Being accountable for shipping, receipt of returned agents, reconciliation of returns and shipments and destruction of unused, returned, expired agents, as per Environmental Protection Agency (EPA), Occupational Safety and Health Administration (OHSA), Department of Transportation (DOT), etc. requirements.

2. Being capable of limited pharmacological evaluations, such as absorption, bio-distribution, metabolism and elimination studies, and special pharmacological studies.

3. Capability for custom synthesis or purchase of investigational agents

4. Ability to undertake evaluation of different agent salt forms and to perform limited formulation/solubility determinations.

5. Maintaining a secure off-site data computerized back-up system with appropriate back-up scheduling.

6. Having database and system recovery and restoration capabilities.

7. Being capable of obtaining and archiving digital photographs of formulated products for identification purposes or comparison with other batches.

8. Retaining archival samples of new agents, bulk materials, finished agents or intermediates and store under appropriate stable and safe conditions for future reference and maintain complete information relating to them.

9. Possessing capability for cold storage (-4C to -40C or -70C) of split-sample sera and other biological fluids and tissues from preclinical studies and clinical trials for time period covering period of performance.

10. Maintaining complete detailed documentation for all electronic information management system and any hardware and software upgrades, updates, patches, modifications, customizations, and patches in order for other system operators and programmers for the contractor or a possible future contractor, to maintain it.

11. Having labeling capability for printing multi-panel labels in FDA-compliant format

12. Having capability for blister-packaging with validated blister materials protocol

13. Possessing capability and appropriate staff to conduct cGMP audits and site visits as specified by and accompanied by the Contracting Officer Technical Representative and/or NCI staff.

OMB No 0990-0115

1. CONTRACT ID CODE PAGE OF PAGES

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT N/A 1 47

2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable)

1 2 March 26, 2018 N/A

6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE N/A National Institutes of Health National Cancer Institute Office of Acquisitions 9609 Medical Center Dr., Rm 1E646, MSC 9705 Bethesda, MD 20892-9705

8. NAME AND ADDRESS OF CONTRACTOR (No. Street, County, State and ZIP: Code) ( ) 9A. AMENDMENT OF SOLICITATION NO.

TO ALL POTENTIAL OFFERORS

N02CN75014-45

9B. DATED (SEE ITEM 11)

Feb. 23, 2018

10A. MODIFICATION OF CONTRACT/ORDER NO.

10B. DATED (SEE ITEM 13)

CODE FACILITY CODE

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers is extended, is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted;

or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and data specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

( ) A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET

FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor is not, is required to sign this document and return 1 copy to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: 1) To provide clarification to questions received by the deadline for questions, March 9, 2018, on RFP N02CN75014- 45, “Centralized Chemopreventive Agent Repository and Chemistry Support”, and subsequently revised RFP Attachment 17, Additional Business Proposal Instructions.

Deadline for Questions: March 9, 2018; 3:00pm ET (Unchanged)

Proposal Due Date: April 9, 2018; 12:00pm ET (Unchanged)

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print) 16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

Catherine A. Muir Contracting Officer, PCPSB, OA, NCI, NIH, DHHS

15B. CONTRACTOR/OFFEROR 15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 16C. DATE SIGNED

(Signature of person authorized to sign)

BY __________________________________ ________

(Signature of Contracting Officer)

March 26, 2018

NSN 7540-01-152-8070 30-105 STANDARD FORM 30 (REV. 10-83)

PREVIOUS EDITION UNUSABLE Computer Generated Prescribed by GSA

FAR (48 CFR) 53.243