LCQTOF ICPqqq SOW_JAM.pdf

Statement of Work For

Liquid Chromatograph Quadrupole Time-of Flight Mass Spectrometer (LC-qTOF-MS)

Inductively Coupled Plasma Triple Quadrupole Mass Spectrometer (ICP-qqq-MS)

1.0 Background

To facilitate chemical analysis of materials and quantitation of species therein, the Government requires a Liquid Chromatograph Quadrupole Time-of Flight Mass Spectrometer (LC-qTOF-MS) and an Inductively Coupled Plasma Triple Quadrupole Mass Spectrometer (ICP-qqq-MS) package.

2.0 Purpose

2.1 This Statement of Work is to define the requirements and deliverables to be used in the selection and procurement of a LC-qTOF-MS and ICP-qqq-MS package to be delivered to DEVCOM AC WSEC Benét Laboratories (Bldg. 115).

3.0 Requirements

3.1 The contractor shall provide a LC-qTOF-MS system with the following required minimum specifications:

3.1.1 The system shall be capable of performing high-resolution mass spectrometric analysis samples:

3.1.1.1 The system shall have an ultra-high pressure liquid chromatography stack including high speed pump with integrated degasser, diode array detector, multi-column thermostat with valve drive, and multisampler with thermostat.

3.1.1.2 The system shall have an electrospray ion source with thermal gradient focusing technology.

3.1.1.3 The system shall have a quadrupole mass resolution of 1.3Da (FWHM) or better and quadrupole isolation mass range between m/z 20-4000 or similar.

3.1.1.4 The system shall have a TOF mass resolution of >35,000 at m/z 118 and >60,000 at m/z 2,722 (independent of acquisition rate) or better and/or at similar m/z, and a mass range of m/z 20-10,000 or similar.

3.1.1.5 The system shall have instrument detection limit sensitivities of <40fg chloramphenicol or better and/or at similar m/z in negative ion mode and <40fg reserpine or better and/or at similar m/z in positive ion mode.

3.1.1.6 The system shall have a linear dynamic range of 5 orders of magnitude or greater.

3.1.1.7 The system shall be capable of performing polarity switching experiments with a duty cycle of 1.0s.

3.1.1.8 The system shall have MS/MS capabilities, with targeted screening and iterative MS/MS functions.

3.1.1.9 The system shall be equipped to perform routine maintenance without the need to vent to atmosphere.

3.1.2 The system shall include any required vacuum pumps, chillers, tubing, and other ancillary equipment required for operation.

3.1.3 The system shall include a workstation with all required hardware, software, and licenses.

3.1.3.1 The workstation shall include all required components for operation of the system, including but not limited to computer, monitor, and peripherals.

3.1.3.2 Software shall be capable of full instrument control, data analysis, and data archiving. Software in combination with the workstation shall allow for complete stand-alone system operation.

3.1.3.2.1 Instrument control software shall provide complete control over all data acquisition parameters, including automatic acquisition, data processing, mass calibration, instrument monitoring, data export functions, and instrument startup/shutdown.

3.1.3.2.2 Analysis software shall allow for mass spectra processing, including elemental composition determination with isotope matching, composition filtering and integrated search of any databases, and isotope pattern modeling.

3.1.3.2.3 Software shall include NIST23 package.

3.1.3.2.4 Software shall include Applied Markets Personal Compound

Database and Library to allow Allows import / export from 3rd party libraries in a compound centric architecture with extensive cheminformatics.

3.1.3.2.5 Software shall allow for report generation, word processing, and tabulated data viewing and manipulation.

3.1.3.3 Software licenses shall be provided for instrument control and any required analysis modules.

3.2 The contractor shall provide an ICP-qqq-MS system with the following required minimum specifications:

3.2.1 The system shall be capable of performing high-resolution mass spectrometric analysis samples:

3.2.1.1 The system shall have a user-programmable multi-rack autosampler with capacity to support up to 360 samples, environmental enclosure, and integrated wash reservoir.

3.2.1.2 The system shall have MS and MS/MS capabilities, and reaction chemistry control to provide reliable quantitation of elemental composition and enable isobaric resolution of compounds.

3.2.1.3 The system shall have high sensitivity, low background, and high sample matrix tolerance to enable ultratrace limits of detection.

3.2.1.4 The system shall provide linear response over 11 orders of magnitude.

3.2.1.5 The system shall be operable in helium mode to provide control of polyatomic interferences.

3.2.2 The system shall include a workstation with all required hardware, software, and licenses.

3.2.2.1 The workstation shall include all required components for operation of the system, including but not limited to computer, monitor, and peripherals.

3.2.2.2 Software shall be capable of full instrument control, data analysis, and data archiving. Software in combination with the workstation shall allow for complete stand-alone system operation.

3.2.2.2.1 Instrument control software shall provide complete control over all data acquisition parameters, including automatic acquisition, data processing, tuning, instrument monitoring, data export functions, and instrument startup/shutdown.

3.2.2.2.2 Analysis software shall allow for mass spectra processing, including elemental composition determination with isotope matching, composition filtering and integrated search of any databases, and isotope pattern modeling.

3.2.2.2.3 Software shall allow for report generation, word processing, and tabulated data viewing and manipulation.

3.2.2.3 Software licenses shall be provided for instrument control and any required analysis modules.

4.0 Installation

4.1 On-site installation shall be performed by the manufacturer at AC DEVCOM-Benét Laboratories located at Watervliet Arsenal, NY, 12189.

5.0 Training

5.1 The contractor shall provide system startup and familiarization for at least three Benét employees on all modes of operation and any required instrument maintenance.

5.2 The contractor shall provide on-site method and application consulting for at least three Benét employees.

6.0 Warranty

6.1 The Contractor shall offer a standard commercial warranty, including service warranty on labor, parts, and materials for all system and workstation components for a minimum period of one (1) year from the date of installation.

7.0 Written Deliverable

7.1 The Contractor shall provide written certification that the installed instrument meets the quoted specifications IAW DI-MISC-81356A.

8.0 General Requirements and Information

8.1 The period of performance of the contract shall commence upon award of the contract and shall be completed upon delivery of the system, which shall occur within 10 months from award of the contract.

8.2 The instrument shall be delivered to:

Cameron Longo US Army DEVCOM AC WSEC Benét Laboratories

FCCD-ACW-BA

Building 115 Watervliet, NY 12189 Phone (518) 266-5244 Email: cameron.m.longo.civ@army.mil mailto:cameron.m.longo.civ@army.mil