This program announcement must be read in conjunction with the General Application Instructions, version CD26_01.

Program Announcement for the Defense Health Agency

Military Burn Research Program

Patient-Centered Research Award

Funding Opportunity Number: HT942526MBRPPCRA

Pre-Application Due: July 7, 2026

Application Due: October 21, 2026 https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01

FY26 Military Burn Patient-Centered Research Award 2

Content

Before You Begin 3

Basic Information Summarizes the funding opportunity, funding details, submission deadlines and review dates

Eligibility Details eligibility factors for the applicant organization and Principal Investigator

Program Description Describes the program mission and intent of the Patient-Centered Research Award;

provides key award information and considerations; and outlines funding details

Application Contents Presents the two-step application process and instructions for preparing a pre-application and full application

Submission Requirements Provides locations for application packages, instructions for submitting pre-applications and full applications, and describes application verification

Application Review Information Outlines the processes for application compliance review, pre-application and full application selection/notification, and risk assessment. Also, details the review criteria for pre-application screening and both tiers of the CDMRP application review process – Peer Review and Programmatic Review

Federal Award Notices Outlines what a successful applicant can expect if recommended for funding

Post-Award Requirements References policy requirements for funded research; outlines reporting requirements and restrictions related to Principal Investigator changes and institutional award transfers

Other Information Outlines criteria for administrative actions including application rejection, modification, withdrawal and withhold

Appendix 1 Includes a checklist for all full application components to facilitate application submission

Appendix 2 Acronym List

FY26 Military Burn Patient-Centered Research Award 3

Before You Begin

• Active SAM.gov, eBRAP.org and Grants.gov registrations are required for application submission. User registration for each of these websites can take several weeks or longer.

Each applicant must ensure their registrations are active and up to date prior to application preparation.

• Read this funding opportunity announcement in the order it is written before beginning to prepare application materials. It is the responsibility of the applicant to determine whether the proposed research meets the intent of this funding opportunity and that all parties meet eligibility requirements.

• To support application preparation, additional resources are available including an application process FAQ, a Guide for Intragovernmental & Intramural Applicants and a CDMRP Video Series detailing the application process.

Who to Contact for Support

This document uses internal links; you can go back to where you were by pressing the Alt + left arrow keys (Windows) or command + left arrow keys (Macintosh) on your keyboard.

Click to be taken to additional guidance and instructions within the General Application Instructions (GAI).

eBRAP Help Desk

301-682-5507 help@eBRAP.org

Questions regarding funding opportunity submission requirements, as well as technical assistance related to pre-application or intramural application submission.

Grants.gov Support Center

800-518-4726 International: 1-606-545-5035 support@grants.gov

Questions regarding Grants.gov registration and Workspace.

https://sam.gov/ https://ebrap.org/eBRAP/public/index.htm https://grants.gov/register https://cdmrp.health.mil/#:~:text=Frequently%20Asked%20Questions%20%C2%BB https://cdmrp.health.mil/#:~:text=Guide%20for%20Intragovernmental%20%26%20Intramural%20Applicants https://ebrap.org/eBRAP/public/Program.htm#:~:text=Journey%20of%20an,Tier%20Review%20Process mailto:help@eBRAP.org mailto:support@grants.gov https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01

Section Shortcuts Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 4

1. Basic Information About the Funding Opportunity

Summary: Despite significant research investment in combat-relevant burn care, a disparity exists between newly discovered knowledge in burn care and its implementation into clinical practice across the distributed operational battlespace. The fiscal year 2026 (FY26) Military Burn Research Program (MBRP) Patient-Centered Research Award (PCRA) seeks to bridge the gap between research, practice, and policy by developing a knowledge base that provides clinically useful findings about how interventions, clinical practices, guidelines, tools, and policies can be deployed to burn patients in an austere, resource-limited, military operational environment.

Distinctive Features:

• This award mechanism must support clinical research or clinical trials but cannot support preclinical or animal research. Applications may propose prospective or retrospective research involving human subjects or human subject data.

• New for FY26: The FY26 MBRP PCRA offers a Mentorship Option at a higher funding level to support a synergistic relationship between an experienced researcher (Mentor) and one to two junior researchers (Mentees). The dual purpose of this award is to fund a primary research study addressing a critical gap in combat burn care while simultaneously fostering the development of the next generation of military burn research leaders.

Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $3.4M to fund approximately two PCRA applications with total cost caps of $1.6M for the basic award or $1.8M for the basic award plus the Mentorship Option. The maximum period of performance is 4 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awards supported with FY26 funds will be made no later than September 30, 2027.

Submission and Review Dates and Times

• Pre-Application (Preproposal) Submission Deadline: 5:00 p.m. Eastern Time (ET), July 7, 2026

• Invitation to Submit an Application: August 26, 2026

• Application Submission Deadline: 11:59 p.m. ET, October 21, 2026

• End of Application Verification Period: 5:00 p.m. ET, October 28, 2026

• Peer Review: January 2027

• Programmatic Review: March 2027

Announcement Type: Initial

Funding Opportunity Number: HT942526MBRPPCRA

Assistance Listing Number: 12.420

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 5

2. Eligibility Information

2.1. Eligible Applicants

2.1.1. Organization

Extramural and intramural U.S. Department of War (DOW) organizations are eligible to apply, including foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities.

2.1.2. Principal Investigator

Independent investigators affiliated with an eligible organization are eligible to be named Principal Investigator (PI) on the application, regardless of ethnicity, nationality or citizenship status.

Mentorship Option: Applications naming clinical or post-doctoral fellows as Mentees are encouraged. A Mentorship Plan (Attachment 13) is required for all applicants selecting the Mentorship Option at the full application stage.

• Principal Investigator (Mentor): Independent investigators affiliated with an eligible organization who demonstrate a record of research success in a burn-relevant field are eligible to be named PI.

• Mentee(s): Must be a clinical fellow or post-doctoral fellow (or junior researcher as determined by their organization) within five years of terminal degree completion. The Mentee(s) must commit a significant level of effort (e.g., at least 50%) to the proposed research project. The application must include a signed Letter of Support from the institution for the Mentor/Mentee relationship.

2.2. Cost Sharing

Cost sharing is not an eligibility requirement.

2.3. Other

Awards are made to eligible organizations, not to individuals. Refer to the GAI for additional recipient qualification requirements.

https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Content_Form_Full_App_Submission:~:text=pre%2Dapplication%20submission.-,Extramural%20Organization%3A,-A%20foreign%20or https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Definition_List:~:text=Intramural%20DOW%20Organization%3A%20A%20subset%20of%20intragovernmental%20organizations%3B%20refers%20specifically%20to%20DOW%20organizations%2C%20including%20DOW%20laborator https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=APPENDIX%201-,RECIPIENT%20QUALIFICATION%20AND%20RESTRICTION%20INFORMATION,-A.%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0

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FY26 Military Burn Patient-Centered Research Award 6

3. Program Description

The Defense Health Agency Contracting Activity (DHACA) is soliciting applications to this funding opportunity using delegated authority provided by United States Code, Title 10, Section 4001 (10 USC 4001). The CDMRP is the program office managing this FY26 funding opportunity as part of the Military Burn Research Program (MBRP). The CDMRP is located within the Defense Health Agency Research and Development (DHA R&D), which is a part of the Department of Defense, DOD, herein referred to using the secondary title Department of War, DOW. Congress initiated the MBRP in 2011 to address the medical needs of traumatically burn-injured military Service Members. Appropriations for the MBRP from FY11 through FY25 totaled $130 million (M). The FY26 appropriation is $10M.

Burn injuries sustained by military Service Members while in the line of duty, whether in the military operational battlespace or in a military training environment, represent a continuous health burden on both the injured Service Member and the DOW health care systems in which they receive care. Historically, burn injuries afflicted between 5% to 20% of casualties during post-World War II conflicts.1 In more recent conflicts, burn injury affected 9% to 10% of combat casualties,2,3,4 and 20% of those burn injuries are characterized as severe.4 While thermal burns represent the most common mechanism of burn injury, other mechanisms such as frostbite, high-voltage electrical, chemical, directed energy, and radiation/nuclear exposure represent additional formidable threats to the health and well-being of Service Members. Regardless of mechanism, combat-associated burn injuries are often devastating due, in part, to the high incidence of concomitant severe traumatic injuries. In addition, compared to burns sustained in a non-combat setting, combat burn injuries are more likely to progress to deep partial- or full-thickness burns, become infected and lead to additional complications. The majority of combat burn injuries incurred during modern conflicts resulted from explosive device detonation, leading to a greater Injury Severity Score, an increase in inhalation injuries, and deeper, larger burns.3 Military planners anticipate that future conflicts will include more powerful weaponry than that seen in the past,5 likely resulting in a higher number of casualties with significant traumatic injuries and larger, more severe burns. Furthermore, compromised evacuation capabilities and interruptions to the medical supply chain could extend battlespace burn care from days to weeks, thereby increasing the risk of negative clinical outcomes. Accurate burn wound assessment and proper treatment of burn wounds and associated complications in a prolonged distributed operational care environment remain difficult. Burn researchers are challenged to innovate, develop, refine and test novel burn therapies, technologies and/or clinical guidelines that facilitate delivery of high-quality burn care in an austere, resource-limited, distributed operational environment for the improvement of both short- and long-term outcomes.

1David S. Kauvar et al, “Burn Hazards of the Deployed Environment in Wartime: Epidemiology of Noncombat Burns From Ongoing United States Military Operations,” Journal of the American College of Surgeons 209, no. 4 (2009):

453-60, https://doi.org/10.1016/j.jamcollsurg.2009.06.367.

2Sandra M. Escolas et al, “Postdischarge Cause-of-Death Analysis of Combat-Related Burn Patients,” Journal of Burn Care and Research: Official Publication of the American Burn Care Association 38, no. 1 (2015): e158-64, https://doi.org/10.1097/BCR.0000000000000319.

3David S. Kauver et al, “Comparison of Combat and Non-Combat Burns From Ongoing U.S. Military Operations,” The Journal of Surgical Research 132, no. 2 (2006): 195-200, https://doi.org/10.1016/j.jss.2006.02.043.

4Kevin K. Chung et al., “Evolution of Burn Resuscitation in Operation Iraqi Freedom,” Journal of Burn Care & Research 27, no. 5 (2006): 606-11, https://doi.org/10.1097/01.BCR.0000235466.57137.f2.

5“Global Trends 2040: The Future of the Battlefield,” Office of the Director of National Intelligence, National

Intelligence Council, last modified March 2021, https://www.dni.gov/index.php/gt2040-home/gt2040-deeper-looks/future-of-the-battlefield.

https://doi.org/10.1016/j.jamcollsurg.2009.06.367 https://doi.org/10.1097/BCR.0000000000000319 https://doi.org/10.1016/j.jss.2006.02.043 https://doi.org/10.1097/01.BCR.0000235466.57137.f2 https://www.dni.gov/index.php/gt2040-home/gt2040-deeper-looks/future-of-the-battlefield https://www.dni.gov/index.php/gt2040-home/gt2040-deeper-looks/future-of-the-battlefield

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FY26 Military Burn Patient-Centered Research Award 7

The MBRP seeks to fund research that enhances the ability of non-burn specialists to accurately assess burn severity, adequately treat burns, mitigate, and/or treat burn-associated complications, and prevent progression of burn depth in an austere, resource-limited, combat environment. Enhancing the ability to provide high-quality burn care within a resource-limited, distributed operational battle space is expected to shorten the time to recovery and improve the long-term physical and psychological health and well-being of burn-injured Service Members, with the potential for benefit among Veterans, military beneficiaries and the American public.

Within this context, the MBRP is interested in research proposals that address specific gaps in the ability to care for combat burn casualties at or close to the point of injury, and in the early acute phase of care where evacuation delays are likely and medical resources are limited.

In order to improve short- and long-term outcomes in combat burn casualties, an urgent need exists to bridge the gap between existing knowledge and its implementation into clinical practice in a combat health care environment.

3.1. Award History

The MBRP first offered the Patient-Centered Research Award (PCRA) mechanism in FY24.

Since then, 33 PCRA applications were received, and two were recommended for funding.

3.2. Intent of the Patient-Centered Research Award

The MBRP wishes to close the gap between the development of new knowledge in burn care and the problems inherent in delivering highly effective burn care practices to the burn-injured Warfighter at the point of need. While hospitals across the United States have access to state-of-the-art, research-based diagnostics and treatments for burn patients, it is difficult to bring an equivalent level of care to the battlefield. This funding opportunity aims to bridge that gap. The goal of the FY26 MBRP PCRA is to fund studies that facilitate the implementation of the best burn care practices into a resource-limited, distributed operational battle space both on land and at sea.

This award mechanism must support clinical research or clinical trials but cannot support preclinical or animal research. Applications may propose prospective or retrospective research involving human subjects or human subject data/records.

PCRA-Mentorship Option: The PCRA with Mentorship Option requires a single PI who will serve as the Mentor for up to two designated Mentees. The full application must name the Mentee(s) and detail a comprehensive Mentorship Plan. The proposed research should be of sufficient scope to support the progressive development of the Mentee’s knowledge, skills, and abilities in burn research.

This application must include a primary study and at least one pilot project, sub-study, or major task tailored to the development of the Mentee. The pilot project/sub-study/major task must complement the primary research aims and be completed by the Mentee(s) under the supervision of the Mentor.

3.2.1. Focus Areas for the PCRA

The proposed study, including the pilot/sub-study if selecting the Mentorship Option, must address at least one of the following focus areas:

• Development and/or validation of methods to triage, treat, and/or prevent complications of cold injury.

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FY26 Military Burn Patient-Centered Research Award 8

• Research to innovate best practices in the acute burn care continuum in a combat setting.

• Development and/or validation of methods for use in a combat setting to prevent, assess and/or treat burn injury-related complications, including:

○ Over/under fluid resuscitation

○ Endotheliopathy

○ Sepsis

○ Inhalation injuries

○ Fungal infections

○ Hypermetabolism

• Interventions applied during the early, acute phase of burn injury that prevent or mitigate later development of chronic pain, neuropathy, pruritus and temperature dysregulation.

3.2.2. Key Elements for the PCRA

The following are important aspects of the FY26 MBRP PCRA:

Impact: The overall impact of the proposed research is a key component of this award mechanism. The application must clearly demonstrate the project’s potential to impact the care provided to burn casualties in austere, resource-limited, distributed operational environment.

High-impact research will, if successful, lead to the development of knowledge to support the broad dissemination and implementation of burn-specific therapeutics, technologies, tools, policies or clinical practice guidance into combat burn care.

Relevance to Military Health: Relevance to the care of burn-injured military Service Members in an austere, resource-limited, distributed operational battle space is a key feature of this award.

Preliminary Data: Inclusion of preliminary data relevant to the proposed clinical research/trial is required. Data must clearly support the rationale for the proposed research.

Study Design Considerations:

• Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should lay out a feasible plan for achievement of accrual goals, including a strategy for inclusion of women and minorities appropriate to the objectives of the study.

Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, ethnicity or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.

• Human Participant Enrollment Start Date: If applicable, enrollment of human study participants is expected to begin no later than six months after the award date.

• Intervention Availability: If applicable, the proposal should describe the documented availability of, and access to, the drug/compound, device and/or other materials needed, as appropriate, for the proposed duration of the study.

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FY26 Military Burn Patient-Centered Research Award 9

• Mentorship Option: Supports a synergistic relationship between an experienced researcher (Mentor) and up to two junior researchers (Mentees). The dual purpose of this award is to fund a primary research study addressing a critical gap in combat burn care while simultaneously fostering the development of the next generation of military burn research leaders.

3.2.3. Other Important Considerations for the Patient-Centered Research Award

In accordance with the National Defense Authorization Act for Fiscal Year 2026, Section 732, CDMRP does not support the conduct of painful research (U.S. Department of Agriculture pain category D or E) involving domestic cats or dogs, except for studies relating to military or service animals.

Clinical trials are allowed within this funding opportunity.

For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research.

All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research, such as those described in the STROBE, CONSORT, SPIRIT and ARRIVE 2.0 guidelines.

Applications from investigators within the DOW and applications involving multidisciplinary collaborations among academia, industry, the DOW, the U.S. Department of Veterans Affairs (VA) and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, their Families and the American Public.

If the proposed research involves more than one institution, a written plan for single IRB review arrangements must be provided at the time of application submission or award negotiation. The lead institution responsible for developing the master protocol and master consent form should be identified and should be the single point of contact for regulatory submissions and requirements.

3.3. Funding Instrument

The types of awards made under the program announcement will be assistance agreements. An assistance agreement can take the form of a grant or cooperative agreement. The level of involvement on the part of the CDMRP during the project’s period of performance is the key factor in determining whether to award a grant or cooperative agreement. If “no substantial involvement” on the part of the CDMRP is anticipated, a grant will be made (31 USC 6304).

Conversely, if “substantial involvement” on the part of the CDMRP is anticipated, a cooperative agreement will be made (31 USC 6305).

The award type, along with the start date, will be determined during the negotiation process.

3.4. Funding Details

Period of Performance: The maximum period of performance is 4 years.

Cost Cap: The application’s total costs budgeted for the entire period of performance should not exceed $1.6M for the Single PI or $1.8M for the PCRA Mentorship Option. If indirect cost rates have been negotiated, indirect costs are to be budgeted in accordance with the organization’s https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Definition_List:~:text=or%20hardware%20procurement.-,Clinical%20Trial%3A,-As%20defined%20in https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Definition_List:~:text=considered%20clinical%20trials.-,Clinical%20Research%3A,-For%20the%20purposes https://www.strobe-statement.org/ https://www.nature.com/articles/s41591-025-03635-5#:~:text=SPIRIT%20and%20CONSORT%20are%20evidence,relevant%20empirical%20evidence%20where%20possible https://www.nature.com/articles/s41591-025-03668-w?fromPaywallRec=false https://arriveguidelines.org/arrive-guidelines https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=Period%20of%20Performance%3A%20The%20time%20interval%20between%20the%20start%20of%20a%20federal%20award%20and%20the%20planned%20end%20date.

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FY26 Military Burn Patient-Centered Research Award 10 negotiated rate. Collaborating organizations should budget associated indirect costs in accordance with each organization’s negotiated rate.

All direct and indirect costs of any subaward or contract must be included in the direct costs of the primary award.

The applicant may request the entire maximum funding amount for a project that may have a period of performance less than the maximum 4 years.

The appropriateness of the budget for the proposed research will be assessed during peer review.

Mentorship Option Applicants: The program reserves the right to reduce the budget to the basic award maximum.

Mentorship Option Applicants: Mentees will be considered key personnel for purposes of prior approval.

Direct Cost Restrictions: For this award mechanism, direct costs:

Must be requested for:

• Travel Costs for the PI to present project information or disseminate project results at one DOW-sponsored meeting (e.g., Military Health System Research Symposium) in Year 2 or 3 of the period of performance.

• Mentorship Option Applicants Only: Travel costs for mentee(s) to attend one annual burn-relevant research meeting or DOW-sponsored meeting (e.g., Military Health System Research Symposium).

May be requested for (not all-inclusive):

• Support for multi-institutional collaborations, including single IRB costs (if applicable).

• Travel in support of multi-institutional collaborations.

• Travel costs for one investigator to travel to one scientific/technical meeting per year. The intent of travel to scientific/technical meetings should be to present project information or disseminate project results from the FY26 MBRP PCRA. These travel costs are in addition to those allowed for a DOW-sponsored meeting.

Must not be requested for:

• Animal research costs.

• Costs for travel to scientific/technical meeting(s) beyond the limits stated above.

• Tuition.

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

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FY26 Military Burn Patient-Centered Research Award 11

4. Application Contents and Format

4.1. Application Overview

Application submission is a two-step process requiring both a pre-application submitted via the Electronic Biomedical Research Application Portal (eBRAP) and a full application submitted through eBRAP or Grants.gov. Depending on the submission portal, certain aspects of the application will differ.

Intramural DOW organizations submitting a full application should follow instructions for submission through eBRAP.

Extramural organizations submitting a full application must follow instructions for submission through Grants.gov.

4.2. Pre-Application Components

Pre-application submissions must include the following components.

Upload documents as individual PDF files unless otherwise noted. Files must comply with the formatting guidelines listed in the GAI.

• Preproposal Narrative (three-page limit): The Preproposal Narrative page limit applies to text and non-text elements (e.g., figures, tables, graphs, photographs, diagrams, chemical structures, drawings) used to describe the project. Inclusion of URLs that provide additional information to expand the Preproposal Narrative and could confer an unfair competitive advantage is prohibited and may result in administrative withdrawal of the pre-application.

The Preproposal Narrative should include the following:

○ Research Idea: State the ideas and reasoning on which the proposed research is based. If applicable, state the intervention to be tested and indicate the phase of clinical trial and/or class of device. State how the research addresses an important problem relevant to combat burn care in an austere, resource-limited, distributed operational battle space. Describe how the proposed research will address an unmet need in combat burn care. Applicants are not required to provide general burn statistics or military burn epidemiologic information unless specifically relevant to the research proposed.

○ Research Strategy: State the central hypothesis to be tested and/or the objective(s) to be reached. Briefly describe the preliminary findings that support the proposed study.

○ Focus Area: Describe how the proposed project addresses at least one of the FY26 MBRP Focus Areas.

○ Impact: Describe the potential impact of the research, both short term and long term.

Describe how the proposed research will lead to the advancement of combat burn care.

Describe how the proposed project, if successful, will represent an improvement over currently available standards of burn care.

○ Relevance to Military Health: Describe how the results of the proposed research are expected to be relevant to combat burn care in an austere, resource-limited, distributed operational environment.

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FY26 Military Burn Patient-Centered Research Award 12

○ Mentorship Option: Indicate your intent to mentor up to two Mentees by including a brief description of your plan to foster a new generation of burn researchers. A full Mentorship Plan is not required at the pre-application stage.

• Pre-Application Supporting Documentation: The items to be included as supporting documentation for the pre-application must be uploaded as individual files and are limited to the following:

○ References Cited (one-page limit): List the references cited (including URLs if available) in the Preproposal Narrative using a standard reference format that includes the full citation (i.e., author[s], year published, reference title, and reference source, including volume, chapter, page numbers, and publisher, as appropriate).

○ List of Abbreviations, Acronyms and Symbols: Provide a list of abbreviations, acronyms and symbols used in the Preproposal Narrative.

○ Key Personnel Biographical Sketches: All biographical sketches should be uploaded as a single combined file. Biographical sketches should be used to demonstrate background and expertise through education, positions, publications and previous work accomplished. For Mentorship Option Applicants, mentees are considered key personnel.

4.3. Full Application Components

Applicants must receive an invitation to submit a full application. Uninvited full application submissions will be rejected.

Each application submission must include the completed full application package for this program announcement. See Appendix 1 for a checklist of the full application components.

(a) SF424 Research & Related Application for Federal Assistance Form (Grants.gov submissions only):

IMPORTANT: When completing the SF424 R&R, enter the eBRAP log number assigned during pre-application submission into Block 4a – Federal Identifier.

(b) Attachments:

Each attachment of the full application components must be uploaded as an individual file in the format specified and in accordance with the formatting guidelines in the GAI.

○ Attachment 1: Project Narrative (15-page limit): Upload as “ProjectNarrative.pdf”.

Describe the proposed project in detail using the outline below.

– Background: Describe how the proposed research project addresses at least one of the FY26 MBRP Focus Areas. Describe in detail the scientific rationale for the primary study, and if applicable, the rationale for a pilot project/sub-study/major task assigned to a Mentee (required for Mentorship Option). Provide a literature review and analysis. Describe the preliminary studies and/or preclinical data that led to the development of the proposed study. If applicable, provide a summary of similar ongoing, planned or completed clinical research and describe how the proposed study differs. Describe how the proposed study improves upon current standards of burn care and addresses an important problem relevant to combat burn care in an austere, resource-limited, distributed operational environment. Include a discussion of any current clinical use of the intervention under investigation, and/or details of its https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=APPENDIX%202.%0AFORMATTING%20GUIDELINES https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=(a)%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0%C2%A0%20SF424%20(R%26R)%20%E2%80%93%20Application%20for%20Federal%20Assistance%20Form https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=%C2%B7-,Project%20Narrative%3A,-Attach%20as%20%E2%80%9CProjectNarrative https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Content_Form_Full_App_Submission:~:text=eBRAP%20User%20Name-,Biographical%20Sketch,-%3A%20This%20file

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 13 study in clinical trials for other indications (as applicable). The background section should clearly support the choice of study variables and should explain the basis for the study questions and/or study hypotheses. This section should establish the relevance of the study and explain the applicability of the proposed research outcomes to the relevant populations.

– Hypothesis/Objectives: Clearly state the hypothesis to be tested (if applicable), a purpose statement, and the objective(s) to be reached for the primary study.

– Specific Aims: Concisely explain the project’s specific aims. These aims should agree with the primary aims and associated tasks described in the Statement of Work (SOW). If the proposed work is part of a larger study, present only aims that this DOW award would fund.

– Research Strategy and Feasibility: Describe the proposed research strategy and feasibility of the approach, addressing the following:

▪ Describe the study design, methods, and analyses, including appropriate controls.

▪ Describe the translational feasibility, appropriateness, and promise of the approach.

▪ Define the specific study outcomes and how they will be measured.

▪ Describe the availability of and access to the necessary study resources. If human-derived biological specimens will be used, describe the sourcing and/or acquisition of samples. If human-derived specimens will be obtained from military Service Members, military Families, and/or Veteran population(s) or dataset(s), describe the feasibility of accessing the samples/dataset(s).

▪ Explain how the study is designed to achieve reproducible and rigorous results, including (if applicable) controls, sample size estimation, power analysis, blinding, randomization and data handling. Consult appropriate guidelines to ensure relevant aspects of rigorous and reproducible research are adequately planned for and, ultimately, reported.

▪ Describe the statistical plan and the rationale for the statistical methodology.

▪ If applicable, explain how the statistical plan compensates for the use of a subpopulation within the recruited sample population to ensure appropriate power can be achieved within the subpopulation.

▪ Describe data collection and handling, including rules for stopping data collection, how outliers will be defined and handled, and identification of primary endpoints/outcomes.

▪ Describe how data will be reported and how it will be assured that the documentation will support a regulatory filing with the U.S. Food and Drug Administration (FDA), or international regulatory agency, if applicable.

▪ Address potential problems and present alternative methods and approaches.

▪ Describe how the research project will be completed within the proposed period of performance.

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 14

○ Attachment 2: Supporting Documentation: Combine and upload as a single file named “Support.pdf”.

There are no page limits for these components unless otherwise noted. Include only components described below; inclusion of items not requested or viewed as an extension of the Project Narrative will result in the removal of those items or may result in administrative withdrawal of the application.

References Cited: List the references cited in the Project Narrative using a standard reference format (include URLs, if available).

List of Abbreviations, Acronyms and Symbols: Provide a list of abbreviations, acronyms and symbols.

Facilities, Existing Equipment and Other Resources: Describe the facilities and equipment available for performance of the proposed project; include any additional facilities or equipment proposed for acquisition at no cost to the award. Indicate whether government-furnished facilities or equipment are proposed for use. If so, reference the original or present government award under which the facilities or equipment items are now accountable. There is not a standardized form for this information.

Publications and/or Patents: Include a list of relevant publication URLs and/or patent abstracts. If articles are not publicly available, then copies of up to five published manuscripts may be included in Attachment 2. Extra items will not be reviewed.

Letters of Support (one-page limit per letter is recommended): Provide individual letters signed by collaborating individuals and/or organizational officials demonstrating that the PI has the support and resources necessary for the proposed work, including support for engaging in a Mentor/Mentee relationship if selecting the Mentorship Option. Letters from the PI’s Department Chair, or appropriate organization official, should also confirm that the PI(s) meet eligibility criteria, including an attestation that the PI possesses a record of research success in a burn-relevant field if selecting the Mentorship Option. If applicable, provide a letter of support signed by the lowest-ranking person with approval authority, confirming participation of intramural DOW collaborator(s) and/or access to military populations, databases or DOW resources. If applicable, provide a letter of support signed by the VA Facility Director(s), or an individual designated by the VA Facility Director(s), confirming access to VA patients, resources and/or VA research space.

Letters of Collaboration (if applicable) (one-page limit per letter is recommended): Provide a signed letter from each collaborating individual and/or organization demonstrating that the PI has the support and resources necessary for the proposed work. If an investigator at an intramural DOW organization is named as a collaborator on a full application submitted through an extramural organization, the application must include a letter from the collaborator’s Commander or Commanding Officer at the intramural DOW organization authorizing the collaborator’s involvement. If selecting the Mentorship Option, provide a signed letter from the Mentee(s) stating the intent to engage in a Mentor/Mentee relationship for the proposed research.

Sex as a Biological Variable Strategy (two-page limit is recommended):

Describe the strategy for how sex will be considered as a biological variable. This strategy should include a brief discussion of what is currently known regarding sex https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=%C2%B7-,Supporting%20Documentation%3A,-Combine%20and%20attach

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 15 differences in the applicable research area. Clearly articulate how sex as a biological variable will be factored into the data analysis plan and how data will be collected and disaggregated by sex. If needed, provide a strong rationale for proposing a single-sex study, based on justification from scientific literature, preliminary data or other relevant considerations. Refer to the CDMRP Directive on Sex as a Biological Variable in Research for additional information.

Intellectual Property: Information can be found in the 2 CFR 200.315, “Intangible Property.”

▪ Intellectual and Material Property Plan (if applicable): Provide a plan for resolving intellectual and material property issues among participating organizations.

▪ Commercialization Strategy (if applicable): Describe the commercialization plan. The plan should include intellectual property, market size, financial analysis, strengths and weaknesses, barriers to the market, competitors, and management team. Discuss the significance of this development effort, when it can be anticipated, and the potential commercial use for the technology being developed.

Research Sharing Plan: Describe the type of data or research resources (e.g., bio-specimen, analysis tool/software, training material) to be made publicly available as a result of the proposed work. Describe the mechanism (e.g., direct sharing, repository, mixed mode) by which data and resources generated during the period of performance will be shared with the research community and other affected communities, including clinical research participants. Include the name of the repository(ies) where scientific data and resources arising from the proposed study will be archived, if applicable. Identify and provide the rationale for any data or resources that will not be shared (e.g., for intellectual property, feasibility, cost or other considerations). The plan should also protect participant privacy, confidential and proprietary data, and performer/third-party intellectual property. Provide a milestone plan for disseminating data/results including when data and resources will be made available to other users. In cases where the study participant could potentially derive medical or other benefit from the information, explain whether the results of screening and/or study participation will be shared with the participant or their primary care provider, including results from any screening or diagnostic tests performed as part of the study.

Do not submit a copy of the National Institutes of Health Data Management and Sharing Plan or duplicate the Data Management Plan which will be requested only after a recommendation for funding is made.

Refer to the CDMRP Directive on Sharing Data and Research Resources for more information about the CDMRP’s expectations for making data and research resources publicly available.

○ Attachment 3: Technical Abstract (one-page limit): Upload as “TechAbs.pdf”.

Write the technical abstract using the outline below. Clarity and completeness within the space limits are highly important.

https://cdmrp.health.mil/pubs/pdf/CDMRP%20SABV%20Directive_Revised_MAR2025_signed.pdf https://cdmrp.health.mil/pubs/pdf/CDMRP%20SABV%20Directive_Revised_MAR2025_signed.pdf https://ebrap.org/eBRAP/public/Program.htm#:~:text=Directive%20on%20Sharing%20Data%20and%20Research%20Resources https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=%C2%B7-,Technical%20Abstract%3A,-Attach%20as%20%E2%80%9CTechAbs

Basic Information | Eligibility | Program Description | Application Contents and Format | Submission Requirements

Application Review Information | Federal Award Notices | Post-Award Requirements | Other Information

FY26 Military Burn Patient-Centered Research Award 16

Background: Present the scientific rationale behind the proposed research project, including how it addresses one or more FY26 MBRP Focus Areas. Mentorship Option applicants should include a brief description of the Mentorship Plan.

Hypothesis/Objective(s): State the hypothesis to be tested and/or objective(s) to be reached.

Specific Aims: State the specific aims of the study.

Study Design: Describe the study design, including appropriate controls.

Impact and Military Relevance: Describe how the study is relevant to military health. State how the proposed project, if successful, will have an impact on the burn research field and/or the care of burn-injured combat casualties and how the research will ultimately improve the lives of combat burn casualties. Describe how the results of the proposed project will benefit burn-injured Service Members in an austere, resource-limited, distributed operational environment. Note any substantial collaborations. Mentorship Option applicants should include a description of the potential impact the Mentor/Mentee plan will have on the burn research field.

○ Attachment 4: Lay Abstract (one-page limit): Upload as “LayAbs.pdf”.

The lay abstract should address the points outlined below in a manner that is readily understood by readers without a background in science or medicine. Avoid overuse of scientific jargon, acronyms and abbreviations. Do not duplicate the technical abstract.

– Summarize the objectives and rationale for the proposed research.

– Clearly describe the critical problem or question to be addressed and the ultimate applicability and impact of the research. Consider the following:

▪ How will one or more of the FY26 MBRP Focus Areas be addressed?

▪ Describe how the results of the proposed project will benefit burn-injured Service Members.

○ Attachment 5: Statement of Work (three-page limit): Upload as “SOW.pdf”.

Refer to eBRAP for the Suggested SOW Format.

For guidance on preparing the SOW, refer to either the Example: Assembling a Clinical Research and/or Clinical Trial Statement of Work or Example: Assembling a Generic Statement of Work, whichever is most appropriate for the proposed effort. Include milestones for data or research resource(s) sharing.

– Mentorship Option Applicants: include tasks specific to the Mentorship Plan.

○ Attachment 6: Intervention (no page limit): Upload as “Intervention.pdf” (REQUIRED FOR CLINICAL TRIAL APPLICATIONS ONLY). The Intervention attachment should include the components listed below:

– Description of the Intervention: Identify the intervention to be tested and describe the particular outcomes and clinical and/or operational needs as they relate to the selected FY26 MBRP focus area. State how the intervention represents care provided in an austere, resource-limited, distributed operational environment, and how it compares with currently available interventions and/or standards of care. As applicable, the description of the intervention should include the following components: complete name of the investigational product, storage and handling information, source, dose, schedule, administration route and duration of the https://ebrap.org/eBRAP/public/Program.htm#:~:text=Suggested%20SOW%20Format https://ebrap.org/eBRAP/public/Program.htm#:~:text=Example%3A%20Assembling%20a%20Clinical%20Research%20and/or%20Clinical%20Trial%20Statement%20of%20Work https://ebrap.org/eBRAP/public/Program.htm#:~:text=Example%3A%20Assembling%20a%20Clinical%20Research%20and/or%20Clinical%20Trial%20Statement%20of%20Work https://ebrap.org/eBRAP/public/Program.htm#:~:text=Example%3A%20Assembling%20a%20Generic%20Statement%20of%20Work https://ebrap.org/eBRAP/public/Program.htm#:~:text=Example%3A%20Assembling%20a%20Generic%20Statement%20of%20Work https://ebrap.org/eBRAP/public/gai.htm?version=CD26_01#_Recipient_Qualification_Restriction_Info:~:text=%C2%B7-,Lay%20Abstract%3A,-Attach%20as%20%E2%80%9CLayAbs…