Attachment_1.doc
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- Attached to
- Chiralir 2X VCD Spectrometer or equivalent
- Solicitation number
- HHS-NIH-NIDA-SSSA-PSOL-15-496
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Project Requirements
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Project Requirements:
Specifically, the NCATS DPI Chemistry group requires the following:
Characteristics Specific to the Design of the ChiralIR-2X:
1. Patent protected Dual Sources for an increased S/N ratio of 3.6
2. Patent protected DualPEM provides reduction of artifacts and expanded applications
3. Patent designed SyncroCell required for measurements of solids and polymers
4. Long-hold MCT Detector: Hold time up to 48 hours - required for small VCD signals
5. The only instrument on the market that does not require lock-ins, or digital filters, increasing efficiency, decreasing cost of ownership.
6. Providing advanced VCD Software packages: ChiralIR Data Acquisition Software, ComputeVOA, CompareVOA Software programs.
7. The only VCD instrument on the market equipped for VCD measurements of liquid AND solid phase Samples.
8. The only VCD Instrument that is delivered as an integrated solution.
| ITEM |
| CHIRALIR-2X VCD SPECTROMETER SPECIFICATIONS |
| Dimensions |
| 24”W x 24”D x 18”H |
| Dual PEM (Photoelastic Modulators) Internal |
| The Internal DualPEM provides improvement and stabilization of the VCD baseline by reduction in the level of birefringent artifacts. |
Provides wider range of experimental flexibility over any single PEM instrument.
No LOCK-IN required, ChiralIR-2X is equipped with all digital signal processing. PEM's are under PC control.
| Dual PEM (Photoelastic Modulators) External |
| The External DualPEM provides improvement and stabilization of the VCD baseline; recommended for the analysis of solids and reaction monitoring applications. Provides wider range of experimental flexibility over any single PEM instrument. |
| Dual Light Source |
| Dual Silicon Carbide Ceramic Light Source |
The Dual Light Source provides increased signal-to-noise (S/N) ~3.6 times over any single source system
| Optical Filter |
| All Digital Signal Processing – No Optical Filter needed due to use of Dual Source |
| Electronic Filter |
| All Digital Signal Processing – No Electronic Filter required |
| Detectors |
| The ChiralIR-2X measures Mid-IR to NIR region with ONE Detector: |
LN2-MCT: Liquid Nitrogen Cooled (MCT) Mercury Cadmium Telluride Standard Spectral Range is 4500 – 750 cm-1
| Built-in Auto-recognition Filter |
| The ChiralIR-2X design specifications require no change of filters as both NIR and MIR measurements are done with the same detector so no need for special recognition is required. |
| Optics |
| ZnSe Coated Optics: ZnSe Optics provide higher throughput and are non-hygroscopic - providing outstanding sensitivity and extended life usage. |
| Lock-in amplifier |
| Digital Signal Processing |
| SyncRoCell |
| Rotating cell for elimination of artifacts. Rotation is necessary for all solid measurements. Provides artifact reduction in cell windows for measurements in solution. Dimensions - 4w x 2d x 6h |
| Sample Cells |
| One 25 mm diameter BaF2 cell |
| AC & DC Converters |
| ChiralIR-2X system measures simultaneously, and continuously monitors, both the AC and DC components for real time IR and VCD data collection. |
| Interferometer |
| A four-point optical design which eliminates retro-modulation induced artifacts. Equipped with 2 cube corner retroreflectors mounted on a ‘wishbone’ swing arm. Scanning is accomplished by rotating the swing arm on a flex pivot bearing, driven by an induction motor. This provides smooth, constant-velocity, perturbation-free scanning. |
Sealed interferometer allowing it to be efficiently purged for elimination of H2O and CO2 interference and protect the interferometer from moisture
| Modulation Frequency |
| 37 KHz modulation frequency. |
| ChiralIR Data Acquisition VCD Software |
| ChiralIR-2X Windows-based integrated Software w/digital signal processing. The software allows automatic phase correction and calibration of VCD intensity. The software is extremely simple to use and is used by students and technicians worldwide. |
| ComputeVOA VCD Software Suite |
| ComputeVOA for Single CPU – an all inclusive package for calculation of VCD spectra and seamless integration with Gaussian09 |
Software includes:
· extensive conformational search
· complete Gaussian09 (included in price)
· Boltzmann averaging
· spectral output (ASCII Format)
| CompareVOA VCD Software Suite |
| CompareVOA Computational Software for comparison of experimental and theoretical data. |
- plots experimental and theoretical spectra as overlap; calculates enantiomer similarity index and provides level of confidence for assignment.
File details come from the government source that posted it. Updated .