160308_SOW_Eurofins_Brimacomb__NOI_Posting.pdf

STATEMENT OF WORK

Program Office: National Center for Advancing Translational Sciences, NCATS National Institutes of Health 9800 Medical Center Drive, Building B, Room B3005 Rockville, MD 20850

Project Officer: TBD

Project Title: Acquisition of fee-for-service pharmacological testing for 15 compounds

Background

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), which mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

NCATS is in need of fee-for-service pharmacological testing for 15 compounds to detect major potential adverse activity. These services will be used to prioritize "hits" and/or "lead" candidates for further development for several important NCATS projects. The panel should consist of 87 primary molecular targets including 13 enzyme and 74 binding assays.

Statement of Objective

NCATS is in need of fee-for-service pharmacological testing for 15 compounds to detect major potential adverse activity.

Scope of Work

Vendor is responsible for providing the following:

Providing a platform testing that allows to detect major potential adverse activity

The panel needs to consist of 87 primary molecular target that include 13 enzyme and 74 binding assays; assay list is included

Vendor must provide primary screening results within two (2) weeks of compound receipt

Screening against targets should be in duplicate and vendor shall provide results for both enzyme and binding assays

Batches will be sent in sets of 5 compounds (3 batches of 5 compounds each).

Batches will be set at varying intervals based on compound performance and synthesis.

Deliverables / Reporting Requirements:

Vendor is responsible for data of 15 small molecules tested in duplicate against 87 targets to Ajit Jadhav at ajadhav@mail.nih.gov within two (2) weeks of receipt.

Period of Performance

Period of performance is July 1, 2016 through June 30, 2017.

Section 508 Electronic and Information Technology Standards

Although software is not 508 compliant, it is to be for internal use only and there are no employees with a disability that are prevented from using the software; NCATS would make accommodations for any future employee who needs one. It would be an undue expense to this small-business vendor to recreate the software to adhere to 508 compliance and the institute could no longer afford it.

CONTRACTING OFFICER'S REPRESENTATIVE (COR)

The following Contracting Officer's Representative (COR) will represent the Government for the purpose of this contract:

Anna Rossoshek

Evaluation Criteria (Requirements)

Technical Approach (75%) o The contractor shall demonstrate their understanding of the requirements and tasks detailed in the scope of work and their technical approach to perform the required tasks outlined.

Price Competitiveness (25%) mailto:ajadhav@mail.nih.gov