Sources_Sought_Notice.pdf

A. Sources Sought Notice: HHS-NIH-NHLBI-CSB-AR-2017-40-AKM (FBO) / HHSN26817AR00002S (FedConnect)

B. Title: GenoLogics Clarity LIMS (Gold Edition) and Implementation Services

C. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified business sources; and (2) their size classification relative to the North American Industry Classification System (NAICS) code 511210 for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method. All capability Statements sent in response to this SOURCES SOUGHT notice must be submitted electronically to Arun Mathur, Contract Specialist, at arun.mathur@nih.gov in either MS Word or Adobe Portable Document Format (PDF), by December 20th, 2016, 9:00 AM, EASTERN TIME under Solicitation Number: HHS-NIH-NHLBI-CSB-AR-2017-40-AKM. FAXES ARE NOT

ACCEPTED

D. Information:

1. Background

Next Generation Sequencing (NGS) data is a critical component of the research conducted by NIAMS Scientists. There has been a steady increase in the use of NGS data in research throughout the NIAMS IRP. The High-Throughput Sequencing Core Facility Manager is now processing up to 300 samples weekly on 3 Illumina Sequencers (HiSeq 2000, HiSeq2500, MiSeq), and the majority of the workflow for submitting the samples for sequencing is a manual process. The current process can no longer effectively support the number of samples submitted for processing.

Samples are submitted ad hoc. Currently there is no central repository or management of information about samples or the resulting datasets. Back in the lab, there is no insight into where in the process the samples are. All communications on status, issues, schedule, etc. are managed via email, phone and in person. Once generated, unless there is an established process within a lab, there is no way to centrally manage the data or the information about the data. For those submitting samples, the process and learning the process is inconsistent as is level of information and quality of information provided with the samples.

The scope and scale of data now being generated by NGS requires a Laboratory Information Management System (LIMS) to support NIAMS Scientists in the preparation, tracking and analysis of the data, as well as to increase the overall quality, integrity and long-term viability and availability of the data.

2. Purpose and Objectives

The purpose of this requirement will be a procurement of GenoLogics Clarity LIMS (Gold Edition) and Implementation Services to support the NIAMS Intramural Research Program (IRP) and High-Throughput Sequencing Core Facility. This product has been identified as the best possible solution, based on needs, costs and risks to provide end-to-end Next Generation Sequencing (NGS) sample tracking, data management and automated data analysis pipelines.

The objectives are to:

• Automate sample preparation, submission, scheduling and run workflow to the fullest extent possible

• Provide an online system to submit samples for processing

• Provide a consolidated repository for NGS Sample Meta-data

• Improve quality of NGS Sample meta-data provided for sequencing

• Automate initial analysis pipeline – conversion to fastq, alignment

• Provide Dashboards, Reporting, and Search capabilities

3. Project Requirements

1. Qty: 1, Description: BaseSpace Clarity LIMS Subscription Renewal (yearly cost)

Other Requirements:

Description of Products:

• The system must be web-based, accessible via the internal NIH network

• The system must be installed on premise, on NIAMS (and NIH where applicable) supported infrastructure

• The system must be free of any security defects that would preclude it from being hosted on NIAMS supported infrastructure

• The system must support login with agency credentials (single sign on)

• The system must be capable of end-to-end sample traceability from sample preparation through analysis, including real-time status tracking

• The system must provide configurable, customizable and enforceable workflows

• The system must be able to perform data validation and enforcement

• The system must be able to integrate with Illumina sequencers as well as supporting scientific instrumentation such as those used for Quality Control

(QC)

• The system must support complete sample histories and a detailed, human readable audit trail

• The system must provide a non-production (staging) environment

• The system must provide an Application Programming Interface (API)

• The system must provide a Reporting Module

• The system must provide a Data Modeling module

• The system must provide a toolkit

• Software updates must be provided

• User Guides/Manuals must be provided

Description of Services:

• System implementation, including installation, integration and configuration services must be provided

• Project management for the vendor implementation team must be provided

• System integration with existing Illumina sequencers and QC instrumentation must be provided

• System training, including Role-based LIMS User training, API training, Toolkit training, Data Model and Reporting Module training must be provided

• Consulting Services for LIMS, API, Toolkit, Data Model and Reporting Module must be provided

• System validation and verification of performance in accordance with software specifications and free of severe errors must be provided

• Installation support for software updates must be provided Software Support must be provided

Delivery/Place of Contract Performance

Delivery 60 days after receipt of award

National Institutes of Health, NIAMS 6701 Democracy Blvd Rm: 750 Bethesda, MD 20817

4. Capability Statement

Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm’s own risk. The following information shall be included in the capability statement:

a. A general overview of the respondents’ opinions about the difficulty and /or feasibility of the potential requirement, and any information regarding innovative ideas or concepts.

b. Information as needed in sufficient details of the respondents’ (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability;

and (e) examples of prior completed Government contracts, references, and other related information.

c. The respondents’ DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZONE, etc) pursuant to the North American Industry Classification System (NAICS) code: 511210, Analytical Laboratory Instrument Manufacturing, Small Business Size, $38.5 Million.

d. Any other information that may be helpful in developing or finalizing the requirements of the potential acquisition.

e. The capability statement shall not exceed 10 single-sided pages (including all attachments, resumes, charts, etc.) presented in single-space and using a 12-point font size minimum, in either Microsoft Word or Adobe Portable Document Format (PDF), with 8-1/2 by 11-inch paper size, and 1-inch top, bottom, left and right margins.

f. All proprietary information should be marked as such. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferably placed under the eligible small business concern’s name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner.

5. Closing Statement

Interested parties shall submit capability statements via the FedConnect web portal (www.fedconnect.net) and reference Sources Sought Number HHSN26817AR00002S.

The due date for receipt of statements is December 20th, 2016 by 9:00 AM Eastern Time. Vendors can register with FedConnect at https://www.fedconnect.net/FedConnect/default.htm. Please note that FedConnect is used by multiple federal agencies and therefore FedConnect assistance will be provided by Compusearch Software Systems, not the NHLBI OA. More information about registration requirements can be found by downloading the FedConnect Ready, Set, Go!

Guide at https://www.fedconnect.net/fedconnect/Marketing/Documents/FedConnect_Ready_S et_Go.pdf. For assistance in registering or for other FedConnect technical questions please call the FedConnect Help Desk at (800) 899-6665 or email at support@fedconnect.net.

This Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Heart, Lung, and Blood Institute (NHLBI).

The NHLBI does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted. As a result of this notice, the NHLBI may issue a Request for Quote (RFQ).

THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NHLBI shall arise as a result of a response to this notice or the NHLBI’s use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are mailto:support@fedconnect.net advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.