D1 SOW 060321.pdf

STATEMENT OF WORK (SOW)

General Information

Title of Project:

Methyltransferase panel screening using Methyltransferase HotSpot Assay for Early Translation Branch (ETB) for DPI_SARS-CoV-2_Variant Trace project

Statement of Need and Purpose:

The purpose of this requisition is to perform panel screening using Methyltransferase HotSpot Assay testing four (4) compounds and thirty-eight (38) targets. The project centers around developing a method to identify whether a molecule inhibits a particular enzyme within the cell.

The importance of this project centers around identifying potent and on-target small molecule inhibitors of a disease-relevant protein.

Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH) which focuses on getting more treatments to more patients more quickly. NCATS is directly addressing this problem by discovering new technologies and other approaches that could greatly accelerate the process of developing and deploying solutions that can be used by all translational researchers.

The Early Translation Branch (ETB) mission is to uncover new small molecule therapeutics and advance the process of therapeutic development.

Overall this project will support ongoing work for small molecule and combination screening, in silico virtual screening, nanobody/antibody design and optimization that are part of NCATS’s ongoing work to support the pandemic response. In addition, we are performing in vitro assays to support ACTIV Trace’s efforts to characterize the response of variant SARS-CoV2 viruses to current vaccine and therapeutic interventions.

Use of the Methyltransferase HotSpot assay platform is required to provide continuity of service based on reliable data with previous results from testing in NCATS methyltransferase program.

Period of Performance:

The period of performance is six (6) weeks from the date of contract award including the receipt of the four (4) compounds (analytes) for the services.

Scope of Work

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below:

Specific Requirements:

STATEMENT OF WORK (SOW)

The vendor shall perform panel screening using Methyltransferase HotSpot Assays for four (4) compounds and thirty-eight (38) targets.

- 38 HMT Full Panel

- 10 dose IC50 singlet assay.

Government Responsibilities:

The Government will not furnish property, facilities, workspace, computers, or other equipment.

The contractor will not use federal facilities. The Government will provide sufficient quantities of the four (4) compounds (analytes) in order for the contractor to accomplish the requirements described above, which the Government anticipates shipping to the Contractor immediately after contract award. The Government will have the responsibility to review and approve the comprehensive reports.

Delivery or Deliverables:

As noted in the Requirements section above, the contractor will provide the data analysis and report for the contents of this statement of work. The data analysis and report shall be submitted electronically to Matthew Hall hallma@mail.nih.gov

Reporting Requirements:

The contractor shall provide weekly updates on the progress of the project, or more often as appropriate. The updates shall be provided electronically to Matthew Hall hallma@mail.nih.gov.

Other Considerations:

Data Rights:

FAR Clause 52.227-14, Rights in Data-General (May 2014) is included in the solicitation and resultant award. Under 52.227-14(c)(1), the contractor must obtain approval from the contracting officer to assert copyright in any data first produced in performance of this contract and published in academic, technical or professional journals, symposia proceedings, or similar works. Under 52.227-14(d)(2), the contractor must obtain approval from the contracting officer to use, release to others, reproduce, distribute, or publish any data first produced or specifically used by the contractor in the performance of this contract.

Confidentiality of Information:

HHSAR Clause 352.224-71, Confidential Information (Dec 2015) is included in the solicitation and resultant award..