CSOF_2023_Presolicitation__1.pdf

THIS IS A RESEARCH AND DEVELOPMENT (R&D) NOTICE OF INTENT, NOT A REQUEST FOR

PROPOSAL (RFP).

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) plans to compete and award a contract for a Chemical Screening and Optimization Facility. This will be a full and open competition resulting in an Indefinite/Delivery, Indefinite/Quantity (IDIQ) Single Task Order contract.

The RFP will be issued VIA SAM.gov on or about April 15, 2023.

The Contraception Research Branch (CRB) of NICHD has identified three gaps within their three main areas of study: 1) Although contraceptive use is commonplace throughout the world, its effects on human health are not well understood. 2) There is a need to develop new contraceptive methods for populations that don't have adequate choices. Current methods also need to be improved upon. 3) Development of new and improved methods of contraception will require research focused on addressing other knowledge gaps such as identification and validation of novel contraceptive drug targets, global identification and reproductive tract specific genes and proteins, development of improved devices and delivery systems.

The CRB hopes to bridge some of these knowledge gaps with the development and improvement of contraception methods through the award of this contract.

The primary objective of this acquisition will be to provide a state-of-the-art facility with the capabilities and capacity to carry out chemical screening and optimization with the goal of identifying potent and safe contraceptive agents. The required research at the Chemical Screening and Optimization Facility (CSOF) will encompass discovery and optimization of small molecule antagonists and/or agonists of validated targets using state-of-the art scientific disciplines to support that goal.

The execution of these varied tasks requires scientific expertise and capability in the areas of medicinal chemistry, assay development, high throughput screening, x-ray crystallography, molecular modeling, mass spectrometry, nuclear magnetic resonance and pharmacology. This joint effort between the CSOF and NIH staff requires effective communication taking place on a regular basis among all participants. It requires maintenance of secure, up-to-date records of all activities and the ability to share documents as required.

Compound inventory needs to be maintained and compound deliveries tracked.

This RFP () will be available electronically on or about April 15, 2023 on SAM.gov http://www.SAM.gov.

Primary Point of Contact:

Adelola St. John, Contracting Officer lk202p@nih.gov

Place of Contract Performance:

Agency: Department of Health and Human Services Office: National Institutes of Health Location: National Institute of Child Health and Human Development

Bethesda, Maryland 20892- 7000 United States

Archiving Policy:

http://www.sam.gov./ mailto:202p@nih.gov

Automatic, 15 days after response date

Allow Vendors To Add/Remove From Interested Vendors:

No

Allow Vendors To View Interested Vendors List:

No