C. CSS_75N95023Q00428_Attachment 1_Purchase Description_Final.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

Title: Inscopix nVue 2.0 System or Equal with Trade-In

1. Statement of Need and Purpose:

The purpose of this requirement is to procure a quantity of one (1) Inscopix nVue 2.0 system or equal in-vivo mini-endoscopic imaging system for the Laboratory of Circuits, Synapses, and Molecular Signaling (LCSMS) within the National Institute of Neurological Disorders and Stroke (NINDS), Division of Intramural Research (DIR). An in-vivo mini-endoscopic imaging system capable of imaging in dual colors is needed for NINDS principal investigators (PIs) and scientific staff to label distinct cell populations and visualize/quantify activity of distinct cell-types for its ongoing intramural research studies.

2. Background Information and Objective:

The NINDS, which is an Institute at the National Institutes of Health (NIH), mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease for all people.

The main goals of the LCSMS are to investigate the neural mechanisms and circuits underlying neuropsychiatric and neurodegenerative disorders. Accordingly, in-vivo imaging experiments are an integral part of this goal. The purchase of an imaging system with dual color will allow the laboratory to simultaneously examine the activity of multiple different cell populations in conjunction with behavioral testing.

To advance the laboratory’s research objectives and goals, it requires a dual-color imaging system capable of being used in-vivo simultaneously with behavioral monitoring.

An in-vivo, mini-endoscopic imaging system capable of imaging in deep brain structures will allow the LCSMS investigators to image two distinct cell-types simultaneously with single-cell resolution in brain regions of interest to the laboratory. This includes imaging calcium dynamics of labeled cell populations, (i.e., static labeling of a cell population followed by dynamic imaging of calcium activity) and conducting dynamic imaging of two cell populations (i.e., imaging calcium dynamics in conjunction with fluorescent biosensors).

3. Generic Name of Product:

In-vivo Mini-endoscopic Imaging System

4. Purchase Description:

For reference purposes, the brand-name in-vivo mini-endoscopic imaging system that meets the need of this requirement is as follows:

Part Number

Brand-Name/Description Manufacturer Quantity

1000- 006810 nVue 2.0 for dual color imaging, includes:

miniature microscope, data acquisition box, data acquisition software, set of 5 baseplates with attached dual color GRIN lens (0.66 diameter x 7.5 mm length), one-year warranty subscription to Inscopix- Care

Inscopix, Inc. One (1)

5. Salient characteristics

The significant, essential physical, functional, performance, or material element(s) that are the Government’s minimum acceptable standards for an equivalent system to meet the government’s objective are as follows:

The in-vivo mini-endoscopic imaging system must have the following:

1. dual color;

2. single-cell resolution;

3. be capable of longitudinal, long-term imaging;

4. in-vivo capabilities that is compatible with behavioral testing;

5. ability to image deep brain structures;

6. be compatible with Gradient Index (GRIN) lens and baseplates (five (5) baseplate covers and one (1) dummy scope, lens that is 0.66mm diameter x 7.5mm length);

7. a data processing software for identifying cells and its individual dynamics; and

8. include a standard one (1) year manufacturers warranty for repairs and/or replacements on any hardware or parts.

6. Quantity:

One (1)

7. Delivery Date, Delivery Address, Installation and Training:

Delivery shall be within 30-60 days after receipt of order (ARO). The delivery shall be addressed to the following NINDS address:

Building 35 / Room 3B-1010 35 Convent Drive Bethesda, MD 20892-3702

The equipment shall be delivered and installed between the hours of 8:00 a.m. and 5:00 p.m., Eastern Standard Time, Monday through Friday, except Federal Holidays. Delivery must be Freight on Board (FOB) Destination and include inside delivery. The equipment shall be delivered and installed in coordination with the Contracting Officer’s Representative (COR) at the time the equipment is ready to be shipped. Original Equipment Manufacturer (OEM) certified technician to perform the setup and installation of the equipment.

The Contractor shall provide an Original Equipment Manufacturer (OEM) certified technician to perform the on-site setup and installation of the equipment and shall provide on-site training within 30 days after equipment installation.

8. Period of Performance:

Not applicable.

9. Option(s):

None

10. Trade-In:

The quoter must take into consideration the following trade-in equipment when providing a quote to offer a discount to the purchase price of the new property in exchange for the old, similar property:

Item Description: 02211013 Model: nVoke 2.0 Manufacturer: Inscopix, Inc.

Serial #: BB-11124707 Condition: Repairable Location of the Equipment: Bldg. 35/Rm. 3B-1014, 35 Convent Drive, Bethesda, MD 20892

PURCHASE DESCRIPTION