Attachment 1 - Purchase Description.pdf

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

Two (2) Microwave Synthesizers to perform chemical synthesis with integrated automated sample processing, brand-name or equal to the Biotage Initiator+ Microwave

System with Robot Sixty.

2. Background Information and Objective:

The Antiviral Program for Pandemics (APP) aims to develop safe and effective antivirals to combat SARS-CoV-2. APP will accelerate the development of a portfolio of promising antivirals that can quickly pivot to combat future pandemics. Having safe and effective oral antiviral candidates ready for deployment in later-stage clinical trials against a newly emergent virus would save lives, reduce serious illness, and prevent overwhelming surges in hospitalizations during a viral outbreak or pandemic. Most chemical reactions require heating, and typically can take several hours to complete. This is a major bottleneck to chemical synthesis. However, a microwave chemical synthesis system allows reactions to be completed in a fraction of the time and will help the APP group develop potential candidates against future pandemic threats by aiding in the synthesis of potential lead compounds to be tested in biological assays, as well as in vivo animal efficacy models.

3. Generic Name of Product:

Microwave Synthesizer to perform chemical synthesis with integrated automated sample processing

4. Purchase Description:

Two (2) Microwave Synthesizers to perform chemical synthesis with integrated automated sample processing, brand-name or equal to the Biotage Initiator+ Microwave

System with Robot Sixty.

5. Salient Characteristics:

The salient characteristics of this requirement are the following:

1) A heating process with a temperature range of 40-300 oC, with a temperature increase of 2-5 oC/sec, depending on solvent and power applied;

2) A reaction time range of up to 96 hours;

3) A working pressure range from 0 to 302 bar (435 psi);

4) A power range of 0-400 W from a magnetron at 2.45 GHz;

5) A reaction volume range of 0.2-20 mL;

6) The capacity for variable agitation via magnetic stirrer (300-900 RPM);

7) Capacity for automated processing of at least 60 samples (rack capacity) to include both large (2x12) vials and small (2x30) vials;

8) A small footprint, no larger than (W x D x H) 625 x 422 x 470 mm;

9) An on-board computer with at least a 10.4” diagonal touch screen interface;

10) Archiving/back-up capability via USB and printing compatibility via LAN; and

11) A minimum of at least 6 months comprehensive warranty.

6. Quantity:

Two units

7. Delivery Date:

Delivery within 90 days ARO.

8. Delivery Address:

NCATS, 9800 Medical Center Dr, Rockville, MD 20850