This Project Grant award of $1,980,309 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 will fund the acquisition of an Orbitrap Astral mass spectrometer system for the Keck MS & Proteomics Resource at Yale University. The advanced instrument will enable rapid, high-resolution protein identification and quantification, supporting a wide range of proteomics research projects across Yale and external investigators. Key expected capabilities include the ability to identify over 9,000 proteins in a 15-minute liquid chromatography gradient, substantially increasing sample throughput and depth of coverage compared to the resource's current instrumentation. This investment will equip the Keck facility with state-of-the-art mass spectrometry capabilities to accommodate increased demand from over 142 Yale and non-Yale investigators, driving advances in areas such as biomarker discovery, single-cell proteomics, and the study of post-translational modifications. The award has strong institutional support, with over $227,000 committed towards long-term service and maintenance costs.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.0m | 7/23/25 |