This Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $350,000 to Rutgers, The State University to acquire a GATAN K3 direct electron detector for their Cryo-Electron Microscopy and Nanoimaging Facility. The detector will enable high-throughput, high-resolution cryo-electron tomography and single-particle cryo-electron microscopy. This advanced imaging capability will support studies of flexible and heterogeneous...
This $1,999,997 Project Grant awarded by the National Institutes of Health (NIH) Office of the Director under the NIH Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of an electron energy filtering system and direct electron detector camera to upgrade the cryogenic electron microscopy (cryo-EM) capabilities at Arizona State University (ASU). This advanced cryo-EM instrumentation will significantly improve the quality and resolution of structural biology data collected...
The National Science Foundation (NSF) awarded a $743,852 Project Grant under the Biological Sciences program (CFDA 47.074) to Saint Louis University (SLU) to acquire a XtalLAB Synergy-R single crystal diffractometer. This advanced instrumentation will enable researchers at SLU and partner institutions to collect high-quality diffraction data from organic compounds and biological macromolecules, supporting a wide range of cutting-edge studies in fields critical for the economy and human...
This National Science Foundation (NSF) Geosciences grant (CFDA 47.050) will provide $490,000 to the Carnegie Institution For Science to acquire an advanced X-ray detector, the EIGER2 S CdTe 9M, for the Advanced Photon Source at Argonne National Laboratory. The new detector will enhance the institution's capabilities to conduct in-situ, high-pressure and high-temperature studies of the structure and composition of Earth and planetary materials, including minerals, melts, and iron alloys. This...
This $1,200,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of a time-resolved cryo-electron microscopy (cryo-EM) method to study the dynamics of diverse biological molecules. The principal investigator will collaborate with three renowned scientific laboratories to apply this technique to investigate the structural changes over time of RNA polymerase, the GLP1R receptor, and the AcrB multi-drug...
The National Institutes of Health (NIH) awarded a $1,425,769 Project Grant under the CFDA 93.351 Research Infrastructure Programs to the Regents of the University of Colorado, doing business as the University of Colorado-Denver, to acquire and integrate a Thermo Fisher Scientific Cryo-Electron Microscopy (Cryo-EM) imaging system. This upgrade at the University of Colorado Anschutz School of Medicine Cryo-Electron Microscopy Facility (ANCEM) will enhance the facility's cryo-EM data quality and...
The National Science Foundation (NSF) awarded a $515,037 Project Grant under the Integrative Activities (CFDA 47.083) program to The Research Foundation For The State University Of New York, doing business as Stony Brook University. The award, effective September 1, 2024 through August 31, 2027, supports the acquisition of a laboratory-based X-ray absorption spectroscopy (XAS) instrument to enable advanced materials characterization research. The XAS instrument allows for high-throughput...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Stanford University and the SLAC National Accelerator Laboratory to continue operating the Stanford-SLAC Cryo-Electron Microscopy Center (S2C2) as a national facility. The $12,915,128 grant, awarded on June 10, 2024, will fund the center's efforts to: 1) upgrade and maintain six cutting-edge cryo-electron microscopes, 2) archive image...
The National Science Foundation (NSF) Office of Integrative Activities (CFDA 47.083) awarded the University of Nevada, Reno (UNR) a $170,881 Project Grant to acquire a single crystal X-ray diffractometer. This highly specialized scientific instrument supports a wide range of multidisciplinary research, including luminescent materials, bacterial communication, chemical ecology, and medicinal chemistry. The diffractometer's dual copper and molybdenum sources enable structural characterization...
This $1,211,143 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of a state-of-the-art 700 MHz NMR spectrometer with a cryogenically cooled probe for the University of Pittsburgh Department of Structural Biology. The new instrument will replace an aging 20-year-old spectrometer and enable reliable, high-sensitivity structural and dynamic analysis of a wide variety of biological systems,...