This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $600,000 to Vanderbilt University Medical Center (VUMC) to add ultra-high performance magnetic field gradients and amplifiers to a 3 Tesla magnetic resonance imaging (MRI) and spectroscopy research scanner. This new equipment will dramatically improve the quality of neuroimaging data, enabling enhanced diffusion tractography, functional MRI, and...
The National Institute of Mental Health (NIMH) awarded a $600,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant will fund the purchase of a Tissuevision Tissuecyte 1600FC Serial Two-Photon Tomography (STPT) microscope to enable high-throughput, high-resolution automated imaging of whole, uncleared rodent brains or spinal cord segments. This advanced imaging system will complement and...
This $656,315 federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will enable Vanderbilt University to acquire a 120kV Transmission Electron Microscope (TEM), the TALOS L120C, to support critical biomedical research. The TEM will be used for screening and optimizing specimen samples prior to analysis on the university's cryo-electron microscopy instrumentation, which is essential for determining high-resolution...
This Project Grant award of $2,000,000 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of a new 3 Tesla MRI scanner at Vanderbilt University Medical Center (VUMC). The advanced scanner with high-performance gradients will enhance VUMC's research capabilities, especially for diffusion imaging and functional MRI of the brain and spine. The award will increase VUMC's MRI research capacity to support over 82 active...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $1,899,234 to Vanderbilt University Medical Center (VUMC) to replace obsolete MRI and PET scanning equipment used for animal research. The award will fund a new integrated MRI-PET scanner with a 7T magnet, which will offer improved image quality, reduced operating costs, and expanded research capabilities compared to the...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $397,319 Project Grant (CFDA 93.351) to Vanderbilt University to purchase an ONI NanoImager super-resolution microscope. This specialized microscope will support cutting-edge NIH-funded research on extracellular vesicles and nanoparticles at Vanderbilt University and Vanderbilt University Medical Center. The NanoImager provides high-resolution imaging capabilities, including single-molecule...
This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...