Project Grant RM1DA065022
- Federal Grant Award Summary Father Flanagan's Boys' Home received a $448,525 Project Grant award effective August 6, 2025, through the Trans-NIH Research Support program (CFDA 93.310) administered by the National Institute on Deafness and Other Communication Disorders (NIDCD). The award supports a mixed-methods research study examining decision-making processes among caregivers and pediatricians regarding late-talking in toddlers, with a completion date of July 31, 2027. The research directly...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Miami's Office of Research Administration at the School of Medicine a $164,190 Project Grant on August 19, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research project, titled "Dopamine Dysregulation and Oxidative Stress in HIV and Methamphetamine Induced Cognitive Impairment," addresses the overlapping public health epidemics of substance use disorder and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Alabama at Birmingham a $2.23 million Project Grant on May 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the molecular mechanisms by which HIV and HIV proteins enhance amphetamine use disorder and psychostimulant abuse escalation. The research focuses on understanding the bidirectional relationship between HIV infection and amphetamine use disorder—termed a...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded J. David Gladstone Institutes a $1,343,271 Project Grant (CFDA 93.279, Drug Use and Addiction Research Programs) effective May 15, 2025, through March 31, 2030, to develop targeted small molecule recruitment strategies for suppressing the HIV transcriptionally active reservoir in individuals with substance use disorder (SUD). The research addresses a critical gap in antiretroviral therapy (ART), which fails to target latent...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded Johns Hopkins University a $668,423 Project Grant effective April 15, 2026, through March 31, 2028, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research investigating MECOM (MDS1 and EVI1 Complex Locus Protein)-associated microglial mechanisms in HIV persistence and methamphetamine-induced neuroinflammation. Johns Hopkins will deliver integrated transcriptomic and proteomic...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $439,180 Project Grant effective September 1, 2025 through August 31, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative, titled "Deconvoluting Dopaminergic Neuronal-Glial Interactions in the Striatum," addresses cognitive dysfunction and chronic pain in people living with HIV (PLWH) who experience concurrent opioid and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $6.99 million to the University of California, San Francisco under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct an in vivo imaging and post-mortem research study examining the effects of methamphetamine (MA) use on immune dysfunction and HIV-1 reservoir transcription among people with HIV on antiretroviral therapy (ART). The project, initiated July 15, 2025, and extending through...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $2.352 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct neurogenomic research on HIV-infected brains exposed to opioids and other substances. The award, dated February 15, 2026, with completion targeted for January 31, 2030, supports two primary research objectives. First, the project will validate single-cell genomic...
- Project Grant Summary Massachusetts Institute of Technology received a $1.65 million project grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on July 15, 2025, with an anticipated completion date of March 31, 2030. The project, titled "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV," delivers advanced computational research analyzing genetic and molecular mechanisms...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $804,728 to the Regents of the University of California at Riverside under the Drug Use and Addiction Research Programs (CFDA 93.279) to support a five-year research project spanning June 1, 2025 through April 30, 2030. This Project Grant will fund research investigating the interaction between methamphetamine use and human immunodeficiency virus (HIV) persistence, specifically examining the role of the...
Father Flanagan's Boys' Home received a $2.18 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded April 1, 2026, with a completion date of March 31, 2031. This five-year research initiative will produce a comprehensive investigation into the neurological pathways linking chronic methamphetamine use and HIV-related cognitive impairment. The project will deliver transformational scientific discoveries through integrated systems biology and multimodal neuroimaging analyses, establishing high-dimensional models that identify molecular mechanisms underlying cognitive dysfunction in people with HIV (PWH). The research team will leverage previously identified neurophysiological markers as primary outcomes while examining key molecular pathways related to mitochondrial dysfunction, inflammation, and neural circuit disruption in the context of comorbid HIV and methamphetamine use disorder. The project represents a multidisciplinary team science approach addressing a critical gap identified as a priority by the Office of AIDS Research. Deliverables will include novel insights into molecular precursors of neural circuit dysfunction that can inform the development of new pharmacotherapeutics. The research will be conducted at the Boys Town, Nebraska facility, utilizing expertise spanning neuroHIV, addiction science, computational neuroscience, systems biology, and machine learning. This award supports basic and translational research directly aligned with NIDA's mission to advance prevention, diagnosis, and treatment strategies for substance use disorders and related health comorbidities.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 3/23/26 |