Project Grant RF1NS142079
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $1.878 million to Mayo Clinic Jacksonville on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to interrogate alpha-synuclein aggregate-associated proteomes and identify modifiers of Lewy body disease. The project, running through August 31, 2029, employs...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $622,792 on May 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify transcriptomic and genomic signatures distinguishing amyotrophic lateral sclerosis spectrum disorders. The award funds research to characterize dysregulated transcripts and pathways driving upper motor neuron versus lower motor neuron pathology across the...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $627,408 on May 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize the C9ORF72 repeat expansion across tissues and cell populations in amyotrophic lateral sclerosis and frontotemporal dementia. The project will employ targeted long-read DNA sequencing to obtain repeat length, methylation profiles, and sequence content...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded Mayo Clinic Jacksonville $242,580 on August 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to decode and target the molecular mechanisms of TRAF7/KLF4 driver mutations in meningioma. The project uses CRISPR-CAS9 gene editing to introduce...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $1.875 million on May 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates enhanced PINK1 kinase activity as a therapeutic strategy against alpha-synuclein pathology and neurodegeneration. The research employs a PINK1 gain-of-function variant (PINK1G411A) to determine whether increasing mitophagy—the selective...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $442,086 on May 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to analyze carotid atherosclerotic plaque morphology and its relationship to stroke risk during carotid revascularization. The recipient will analyze baseline carotid duplex ultrasound images from 2,000 patients enrolled in the CREST-2 multicenter randomized trial to...
- Federal Project Grant Award Summary Mayo Clinic Jacksonville has been awarded $683,819 under the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) for a three-year project period from August 15, 2025 through August 14, 2028. The project, titled "Targeting the Polycomb Repressive Complex 2 in Neurofibromatosis Type 2 and Schwannomatosis," will be conducted at the organization's Jacksonville, Florida facility under the direction of Scott Lynch, MD....
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $599,699 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop chimeric antigen receptor T-cell and tumor-infiltrating lymphocyte immunotherapies targeting glioblastoma. The research applies a "double-hit" strategy combining two adoptive T-cell therapies administered via Ommaya reservoir to bypass the...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $219,510 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop noninvasive cell-free DNA biomarkers for early detection and treatment monitoring of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1. The research will integrate cell-free DNA epigenomic features—including methylation patterns and...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $634,938 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate RNA editing dysregulation in dementia with Lewy bodies and Parkinson's disease. The research addresses how proteostasis failure in these neurodegenerative conditions leads to accumulation of nuclear inclusions containing RNA binding proteins NONO and SFPQ,...
The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $1,879,248 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to employ long-read sequencing technologies to identify genomic variation and disease-relevant transcripts contributing to Lewy body dementia and frontotemporal lobar degeneration. The research will detect structural variants, copy number variants, translocations, inversions, and repeat expansions that remain hidden with standard short-read sequencing and have stayed undetected despite discovery of multiple disease-associated loci in the majority of patients with these conditions. The project comprises two primary aims: resolving genomic architecture through structural-variation detection and identifying isoform-specific transcripts using long-read sequencing of post-mortem brain tissue. A third component will interrogate the long-read transcriptome using single-nuclei RNA sequencing to capture splicing events and dysregulated expression patterns implicated in neurodegeneration. Place of performance is Jacksonville, Florida. The period of performance extends from the award date through July 31, 2029. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 9/3/26 |