Project Grant RF1NS132912

Award Date 9/1/23
Completion Date 8/31/26
Dollars Obligated $2.7M
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
California, USA
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The University of California, Los Angeles (UCLA) received a $2,686,858 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The purpose of this award is to conduct research on the neural circuits and mechanisms underlying social buffering, which refers to how social interactions can help mitigate negative emotional states induced by stress.

The research team, led by UCLA and including collaborators at the University of Southern California, will use in vivo calcium imaging, electrophysiological recording, functional manipulation, and computational modeling to investigate how social signals from the medial amygdala suppress persistent neural activity in the medial preoptic area that maintains a negative emotional state after stress exposure. This work aims to provide new insights into the neural circuit basis of social buffering and how it can be leveraged to improve stress resilience and wellbeing. The award period runs from September 1, 2023 to August 31, 2026.

Additionally, UCLA has received two sub-awards under this project grant. One sub-award to Northwestern University will support computational modeling and analysis of the neural and behavioral data. The other sub-award to the University of Southern California will contribute to the overarching investigation of the proposed neural circuit mechanisms underlying social buffering.

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