The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 3-year, $3,582,963 Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to Carnegie Mellon University (CMU). The grant supports the development and validation of novel wearable transcranial focused ultrasound (TFUS) neuromodulation transducer array probes compatible with simultaneous electrophysiological recordings in behaving small and large animal models. The project aims to advance noninvasive, high-precision neuromodulation capabilities for probing neural circuit mechanisms and enabling non-pharmacological treatment of brain disorders. Key deliverables include 64-element TFUS probe prototypes, optimized stimulation parameters, and performance validation through neural activity measurements and behavioral assessments in rats and non-human primates. CMU will collaborate with sub-awardees from the University of Pittsburgh and Rice University to integrate complementary neural recording and stimulation technologies.
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